KEGG   ORTHOLOGY: K11395Help
Entry
K11395                      KO                                     

Name
kdpgA
Definition
2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase [EC:4.1.2.55]
Pathway
Pentose phosphate pathway
Galactose metabolism
Carbon metabolism
Module
M00309  
Non-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate
M00633  
Semi-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate-3P
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01200 Carbon metabolism
    K11395  kdpgA; 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
  Carbohydrate metabolism
   00030 Pentose phosphate pathway
    K11395  kdpgA; 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
   00052 Galactose metabolism
    K11395  kdpgA; 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Central carbohydrate metabolism
    M00633  Semi-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate-3P
     K11395  kdpgA; 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
    M00309  Non-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate
     K11395  kdpgA; 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.55  2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
     K11395  kdpgA; 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
BRITE hierarchy
Other DBs
Genes
HAL: 
VNG_0444G(dapA)
HSL: 
OE_1665R(kdgA)
TAC: 
TVO: 
TVG0663048(TVG0663048)
PTO: 
FAC: 
SSO: 
SSO3197(eda)
SOL: 
SSOA: 
SSOL: 
SSOF: 
SULC_0968
STO: 
STK_24790(kdgA)
SAI: 
Saci_0225
SACN: 
SacN8_01090
SACR: 
SacRon12I_01090
SACS: 
SUSAZ_01130
SIS: 
LS215_2326
SIA: 
M1425_2163
SIM: 
M1627_2243
SID: 
M164_2166
SIY: 
YG5714_2289
SIN: 
YN1551_0626
SII: 
LD85_2429
SIH: 
SiH_2108
SIR: 
SiRe_2040
SIC: 
SiL_2015
SULA: 
BFU36_06090
MSE: 
Msed_1296
MCN: 
Mcup_0949
AHO: 
Ahos_0260
PAS: 
Pars_1388
PYR: 
P186_1933
POG: 
Pogu_0825
TUZ: 
TUZN_0957
TTN: 
TTX_1156a(kdgA)
AG: 
CAA11866
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Ahmed H, Ettema TJ, Tjaden B, Geerling AC, van der Oost J, Siebers B
  Title
The semi-phosphorylative Entner-Doudoroff pathway in hyperthermophilic archaea: a re-evaluation.
  Journal
Biochem J 390:529-40 (2005)
DOI:10.1042/BJ20041711
Reference
  Authors
Ettema TJ, Ahmed H, Geerling AC, van der Oost J, Siebers B
  Title
The non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (GAPN) of Sulfolobus solfataricus: a key-enzyme of the semi-phosphorylative branch of the Entner-Doudoroff pathway.
  Journal
Extremophiles 12:75-88 (2008)
DOI:10.1007/s00792-007-0082-1
LinkDB All DBs

KEGG   ORTHOLOGY: K18127Help
Entry
K18127                      KO                                     

Name
kdgA
Definition
2-dehydro-3-deoxy-D-gluconate aldolase [EC:4.1.2.51]
Pathway
Pentose phosphate pathway
Galactose metabolism
Carbon metabolism
Module
M00309  
Non-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01200 Carbon metabolism
    K18127  kdgA; 2-dehydro-3-deoxy-D-gluconate aldolase
  Carbohydrate metabolism
   00030 Pentose phosphate pathway
    K18127  kdgA; 2-dehydro-3-deoxy-D-gluconate aldolase
   00052 Galactose metabolism
    K18127  kdgA; 2-dehydro-3-deoxy-D-gluconate aldolase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Central carbohydrate metabolism
    M00309  Non-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate
     K18127  kdgA; 2-dehydro-3-deoxy-D-gluconate aldolase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.51  2-dehydro-3-deoxy-D-gluconate aldolase
     K18127  kdgA; 2-dehydro-3-deoxy-D-gluconate aldolase
BRITE hierarchy
Other DBs
Genes
TAC: 
TVO: 
TVG1289977(TVG1289977)
PTO: 
TaxonomyKoalaUniProt
Reference
  Authors
Reher M, Fuhrer T, Bott M, Schonheit P
  Title
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  Journal
J Bacteriol 192:964-74 (2010)
DOI:10.1128/JB.01281-09
  Sequence
[pto:PTO1279]
LinkDB All DBs

KEGG   ENZYME: 4.1.2.51Help
Entry
EC 4.1.2.51                 Enzyme                                 

Name
2-dehydro-3-deoxy-D-gluconate aldolase;
Pto1279 (gene name);
KDGA;
KDG-specific aldolase
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
2-dehydro-3-deoxy-D-gluconate D-glyceraldehyde-lyase (pyruvate-forming)
Reaction(IUBMB)
2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde [RN:R08570]
Reaction(KEGG)
R08570;
(other) R10616
Show
Substrate
2-dehydro-3-deoxy-D-gluconate [CPD:C00204]
Product
pyruvate [CPD:C00022];
D-glyceraldehyde [CPD:C00577]
Comment
The enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. In the direction of aldol synthesis the enzyme catalyses the formation of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate at a similar ratio. It shows no activity with 2-dehydro-3-deoxy-D-gluconate 6-phosphate. cf. EC 4.1.2.14, 2-dehydro-3-deoxy-phosphogluconate aldolase.
History
EC 4.1.2.51 created 2013
Pathway
Pentose phosphate pathway
Galactose metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K18127  
2-dehydro-3-deoxy-D-gluconate aldolase
Genes
TAC: 
TVO: 
TVG1289977(TVG1289977)
PTO: 
Taxonomy
Reference
1  [PMID:20023024]
  Authors
Reher M, Fuhrer T, Bott M, Schonheit P
  Title
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  Journal
J. Bacteriol. 192 (2010) 964-74.
  Sequence
[pto:PTO1279]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
LinkDB All DBs

KEGG   ENZYME: 4.1.2.55Help
Entry
EC 4.1.2.55                 Enzyme                                 

Name
2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase;
2-keto-3-deoxygluconate aldolase (ambiguous);
KDGA (ambiguous)
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
2-dehydro-3-deoxy-6-phospho-D-gluconate/2-dehydro-3-deoxy-6-phospho-D-galactonate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)
Reaction(IUBMB)
(1) 2-dehydro-3-deoxy-6-phospho-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate [RN:R05605];
(2) 2-dehydro-3-deoxy-6-phospho-D-galactonate = pyruvate + D-glyceraldehyde 3-phosphate [RN:R01064]
Reaction(KEGG)
Substrate
2-dehydro-3-deoxy-6-phospho-D-gluconate [CPD:C04442];
2-dehydro-3-deoxy-6-phospho-D-galactonate [CPD:C01286]
Product
pyruvate [CPD:C00022];
D-glyceraldehyde 3-phosphate [CPD:C00118]
Comment
In the archaeon Sulfolobus solfataricus the enzyme is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway. It utilizes 2-dehydro-3-deoxy-6-phosphate-D-gluconate and 2-dehydro-3-deoxy-6-phosphate-D-galactonate with similar catalytic efficiency. In vitro the enzyme can also catalyse the cleavage of the non-phosphorylated forms 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate with much lower catalytic efficiency. cf. EC 4.1.2.21, 2-dehydro-3-deoxy-6-phosphogalactonate aldolase, and EC 4.1.2.14, 2-dehydro-3-deoxy-phosphogluconate aldolase.
History
EC 4.1.2.55 created 2014
Pathway
Pentose phosphate pathway
Galactose metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K11395  
2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
Genes
HAL: 
VNG_0444G(dapA)
HSL: 
OE_1665R(kdgA)
TAC: 
TVO: 
TVG0663048(TVG0663048)
PTO: 
FAC: 
SSO: 
SSO3197(eda)
SOL: 
SSOA: 
SSOL: 
SSOF: 
SULC_0968
STO: 
STK_24790(kdgA)
SAI: 
Saci_0225
SACN: 
SacN8_01090
SACR: 
SacRon12I_01090
SACS: 
SUSAZ_01130
SIS: 
LS215_2326
SIA: 
M1425_2163
SIM: 
M1627_2243
SID: 
M164_2166
SIY: 
YG5714_2289
SIN: 
YN1551_0626
SII: 
LD85_2429
SIH: 
SiH_2108
SIR: 
SiRe_2040
SIC: 
SiL_2015
SULA: 
BFU36_06090
MSE: 
Msed_1296
MCN: 
Mcup_0949
AHO: 
Ahos_0260
PAS: 
Pars_1388
PYR: 
P186_1933
POG: 
Pogu_0825
TUZ: 
TUZN_0957
TTN: 
TTX_1156a(kdgA)
 » show all
Taxonomy
Reference
1  [PMID:10527934]
  Authors
Buchanan CL, Connaris H, Danson MJ, Reeve CD, Hough DW
  Title
An extremely thermostable aldolase from Sulfolobus solfataricus with specificity  for non-phosphorylated substrates.
  Journal
Biochem. J. 343 Pt 3 (1999) 563-70.
  Sequence
Reference
2  [PMID:16330030]
  Authors
Lamble HJ, Theodossis A, Milburn CC, Taylor GL, Bull SD, Hough DW, Danson MJ
  Title
Promiscuity in the part-phosphorylative Entner-Doudoroff pathway of the archaeon  Sulfolobus solfataricus.
  Journal
FEBS. Lett. 579 (2005) 6865-9.
  Sequence
Reference
3  [PMID:17176250]
  Authors
Wolterink-van Loo S, van Eerde A, Siemerink MA, Akerboom J, Dijkstra BW, van der Oost J
  Title
Biochemical and structural exploration of the catalytic capacity of Sulfolobus KDG aldolases.
  Journal
Biochem. J. 403 (2007) 421-30.
  Sequence
[sso:SSO3197] [sai:Saci_0225] [sto:STK_24790]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
LinkDB All DBs

KEGG   REACTION: R08570Help
Entry
R08570                      Reaction                               

Name
2-dehydro-3-deoxy-D-gluconate D-glyceraldehyde-lyase (pyruvate-forming)
Definition
2-Dehydro-3-deoxy-D-gluconate <=> D-Glyceraldehyde + Pyruvate
Equation
Reaction class
C00022_C00204
C00204_C00577
Enzyme
4.1.2.51        4.1.2.55
Pathway
Pentose phosphate pathway
Metabolic pathways
Microbial metabolism in diverse environments
Carbon metabolism
Module
M00309  
Non-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate
Orthology
K11395  
2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase [EC:4.1.2.55]
K18127  
2-dehydro-3-deoxy-D-gluconate aldolase [EC:4.1.2.51]
Other DBs
RHEA: 
LinkDB All DBs

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