KEGG ORTHOLOGY: K11459

ORTHOLOGY: K11459

Entry

K11459                      KO

Symbol

PCGF4, BMI1

Name

polycomb group RING finger protein 4

Pathway

map03083

Polycomb repressive complex

map04550

Signaling pathways regulating pluripotency of stem cells

map05202

Transcriptional misregulation in cancer

map05206

MicroRNAs in cancer

Disease

H00025

Penile cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    K11459  PCGF4, BMI1; polycomb group RING finger protein 4
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K11459  PCGF4, BMI1; polycomb group RING finger protein 4
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K11459  PCGF4, BMI1; polycomb group RING finger protein 4
   05206 MicroRNAs in cancer
    K11459  PCGF4, BMI1; polycomb group RING finger protein 4
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11459  PCGF4, BMI1; polycomb group RING finger protein 4
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   Polycomb repressive complex (PRC) and associated proteins
    Canonical PRC1 (PRC1.2/1.4)
     K11459  PCGF4, BMI1; polycomb group RING finger protein 4

Genes

HSA:	100532731(COMMD3-BMI1) 648(BMI1)

PTR:	100610220 466023(BMI1) 736264

PPS:	100982779(BMI1)

GGO:	101127543(BMI1)

PON:	100173052(BMI1)

NLE:	100584115(BMI1)

HMH:	116478062(BMI1)

MCC:	106992288(BMI1)

MCF:	101865056(BMI1)

MTHB:

126962721

MNI:	105480043(BMI1)

CSAB:

103237994(BMI1)

CATY:

105583795(BMI1)

PANU:

101025525(BMI1)

TGE:	112631093(BMI1)

MLEU:

105547669

RRO:	104665676(BMI1)

TFN:	117082818(BMI1)

PTEH:

111549937(BMI1)

CANG:

105527518

CJC:	100386061(BMI1)

SBQ:	101028625(BMI1)

CIMI:

108291478(BMI1)

MMUR:

105872911

LCAT:

123625943(BMI1)

PCOQ:

105810344(BMI1)

OGA:

100944176

MMU:	12151(Bmi1)

MCAL:

110284988(Bmi1)

MPAH:

110317823(Bmi1)

RNO:	307151(Bmi1)

MCOC:

116091236

ANU:	117713549(Bmi1)

MUN:	110545767(Bmi1)

CGE:

100754672

MAUA:

101840850(Bmi1)

PROB:

127237456(Bmi1)

PLEU:

114693917(Bmi1)

MORG:

121432618(Bmi1)

MFOT:

126507873

AAMP:

119816341(Bmi1)

NGI:	103732985(Bmi1)

HGL:	101705973(Bmi1)

CPOC:

100722133(Bmi1)

CCAN:

109688873(Bmi1)

DORD:

105984494

DSP:	122113043(Bmi1)

PLOP:

125366841(Bmi1)

NCAR:

124960543 124961791

MMMA:

107150262(Bmi1)

OCU:

100009347

OPI:	101518514(BMI1)

TUP:	102481741(BMI1)

GVR:

103607913

CFA:	487097(BMI1)

CLUD:

112670332(BMI1)

VVP:	112931103(BMI1)

VLG:	121497537(BMI1)

NPO:	129513974(BMI1)

AML:	100464971(BMI1)

UMR:	103664230(BMI1)

UAH:	113241342(BMI1)

UAR:	123785461(BMI1)

ELK:

111155498

LLV:

125106729

MPUF:

101679276(BMI1)

MNP:	132020104(BMI1)

MLK:	131838175(BMI1)

NVS:	122890849(BMI1)

ORO:	101365961(BMI1)

EJU:	114217320(BMI1)

ZCA:	113914322 113921888(BMI1)

MLX:	118021512(BMI1)

NSU:	110586585(BMI1)

LWW:	102727881(BMI1)

FCA:	554342(BMI1)

PYU:	121014729(BMI1)

PCOO:

112867811

PBG:	122473714(BMI1)

PVIV:

125170329(BMI1)

LRUF:

124501576

PTG:	102973015(BMI1)

PPAD:

109273652(BMI1)

PUC:

125918627

AJU:

106987195

HHV:	120232365(BMI1)

BTA:	510666(BMI1)

BOM:	102272593(BMI1)

BIU:	109567937(BMI1)

BBUB:

102401299(BMI1)

BBIS:

105003004(BMI1)

CHX:	102191809(BMI1)

OAS:	101103337(BMI1)

BTAX:

128058229(BMI1)

ODA:	120869319(BMI1)

CCAD:

122448232(BMI1)

MBEZ:

129557599(BMI1)

SSC:	100520800(BMI1)

CFR:	102520972(BMI1)

CDK:	105084911(BMI1)

VPC:	102531304(BMI1)

BACU:

103015809(BMI1)

BMUS:

118890446(BMI1)

LVE:	103072022(BMI1)

OOR:	101270487(BMI1)

DLE:	111178052(BMI1)

PCAD:

102993164(BMI1)

PSIU:

116749411(BMI1)

NASI:

112413803

ECB:

102148742

EPZ:	103543653(BMI1)

EAI:

106846324

MYB:	102248520(BMI1)

MYD:	102771048(BMI1)

MMYO:

118674019(BMI1)

MLF:	102418261(BMI1)

PKL:	118731315(BMI1)

EFUS:

103292601(BMI1)

MNA:	107546349(BMI1)

DRO:	112319054(BMI1) 112319558

SHON:

118995171(BMI1)

AJM:	119063908(BMI1)

PDIC:

114493100(BMI1)

PHAS:

123831111(BMI1)

MMF:	118634402(BMI1)

PPAM:

129086293(BMI1)

HAI:	109394756(BMI1)

RFQ:	117019167(BMI1)

PALE:

102883452(BMI1)

PGIG:

120614668(BMI1)

PVP:	105294927(BMI1)

RAY:	107499931(BMI1)

MJV:	108396421(BMI1)

TOD:	119244742(BMI1)

SARA:

101543102(BMI1)

SETR:

126014485(BMI1)

LAV:

100669380

TMU:

101346404

ETF:	101654007(BMI1)

DNM:	101420336(BMI1)

MDO:	100019794(BMI1)

GAS:

123248750

SHR:	100928474(BMI1)

AFZ:

127539485

PCW:	110194502(BMI1)

OAA:

100075752

GGA:	493647(BMI1)

PCOC:

116243237

MGP:

100538813

CJO:

107308883

TPAI:

128085218(BMI1)

LMUT:

125696143(BMI1)

NMEL:

110395191

APLA:

101804672

ACYG:

106030141(BMI1)

CATA:

118247387(BMI1)

AFUL:

116486356(BMI1)

TGU:	105758969(BMI1)

LSR:

110470611

SCAN:

103813095(BMI1)

PMOA:

120502765

OTC:	121338068(BMI1)

PRUF:

121364863(BMI1)

GFR:	102039747(BMI1)

FAB:	101812886(BMI1)

PHI:

102104382

PMAJ:

107198302

CCAE:

111944121(BMI1)

CCW:	104689224(BMI1)

CBRC:

ETL:

ZAB:

ACHL:

MMEA:

130584000(BMI1)

HRT:	120753764(BMI1)

FPG:	101913761(BMI1)

FCH:	102046406(BMI1)

CLV:

102091417

EGZ:

104125272

NNI:

104016218

PCRI:

104031332(BMI1)

PLET:

104614645(BMI1)

PCAO:

104039978(BMI1)

ACUN:

113477190

TALA:

104356044(BMI1)

PADL:

103922422(BMI1)

AFOR:

103895609

ACHC:

115339623(BMI1)

HALD:

104310531(BMI1)

HLE:	104828829(BMI1)

AGEN:

126037666

GCL:

127013472

CCRI:

104159970(BMI1)

CSTI:

104551457(BMI1)

CMAC:

104474535(BMI1)

MUI:	104547008(BMI1)

BREG:

104630147(BMI1)

GSTE:

104255717(BMI1)

LDI:	104343856(BMI1)

MNB:	103772954(BMI1)

OHA:

104332514

NNT:	104400078(BMI1)

SHAB:

115613365(BMI1)

DPUB:

104307960

PGUU:

104461272

ACAR:

104521323(BMI1)

CPEA:

104397085

AVIT:

104268792(BMI1)

CVF:

104288356

RTD:	128906071(BMI1)

CUCA:

104057686

TEO:

104374928

BRHI:

104500153(BMI1)

AAM:

106490019

AROW:

112965697

NPD:	112947385(BMI1)

TGT:

104567063

DNE:

112982310

SCAM:

104143296

ASN:	102371462(BMI1)

AMJ:	102568375(BMI1)

CPOO:

109307973

GGN:

109291329

PSS:	102449917(BMI1)

CMY:

102936272

CCAY:

125631360(BMI1)

DCC:

119851346

CPIC:

101937567(BMI1)

TST:

117872135

CABI:

116822062(BMI1)

MRV:

120398271

ACS:

100567594

ASAO:

132778906(BMI1)

PVT:

110083403

SUND:

121932907(BMI1)

PMUR:

107283632(BMI1) 107293940

CTIG:

120302651(BMI1)

TSR:	106545612 106553910

PGUT:

117655158

APRI:

131197652(BMI1)

PTEX:

113440087(BMI1) 113451907

NSS:	113417353(BMI1) 113427310

VKO:

123020861

PMUA:

114607176(BMI1)

PRAF:

128424045(BMI1)

ZVI:

118091978

HCG:	128330162(BMI1)

GJA:	107109392(BMI1)

STOW:

125440851(BMI1)

EMC:	129337481(BMI1)

XLA:	398052(bmi1.S) 494698(bmi1.L)

XTR:	548749(bmi1)

NPR:

108793036

RTEM:

120941054

BBUF:

121002829(BMI1)

BGAR:

122937836(BMI1)

MUO:

115467879

GSH:

117354230

DRE:	321505(bmi1a) 394249(bmi1b)

SRX:	107718099 107722592 107727233 107741809

SANH:

107686702 107688441 107689401 107695394(bmi1)

SGH:	107549204 107585379 107589825 107595126

CCAR:

109059640 109074720(bmi1) 109103056

CAUA:

113042272(bmi1) 113045862 113066019 113116809

CGIB:

127946577 127950409 128013372 128028084

PTET:

122330035(bmi1a) 122359327(bmi1b)

LROH:

127154930(bmi1b) 127156077

OMC:	131520703(bmi1b) 131533370

PPRM:

120475949(bmi1a) 120482944(bmi1b)

RKG:	130070942(bmi1b) 130087648

MAMB:

125250387(bmi1b) 125257761(bmi1a)

CIDE:

127506025 127506166

MASI:

127434411 127440992 127441932

TROS:

130547166(bmi1a) 130553937(bmi1b)

TDW:	130413553(bmi1a) 130415064(bmi1b)

MANU:

129426056 129442307(bmi1b)

IPU:	108256741(bmi1a) 108280883(bmi1b)

IFU:	128623935(bmi1b)

PHYP:

113541320 113542962

SMEO:

124375533(bmi1a) 124403344(bmi1b)

TFD:	113640422(bmi1b) 113662101(bmi1a)

TVC:	132839926 132848350(bmi1b)

AMEX:

103025408(bmi1) 103034194

CMAO:

118797360(bmi1b) 118798875(bmi1a)

EEE:	113581701 113589058(bmi1)

CHAR:

105900628(bmi1b) 105905266(bmi1a)

TRU:	101067697(bmi1)

TFS:	130513935(bmi1a)

TNG:	GSTEN00015488G001

LCO:	104922371(bmi1)

NCC:	104945773(bmi1)

TBEN:

117484010(bmi1a)

CGOB:

115025416(bmi1)

PGEO:

117465714(bmi1a)

GACU:

117535357(bmi1a)

EMAC:

134858155(bmi1a)

ELY:	117264840(bmi1a)

EFO:	125881549(bmi1a)

PLEP:

121960983

SLUC:

116037950(bmi1a)

ECRA:

117938317(bmi1a)

ESP:	116672267(bmi1)

PFLV:

114549323(bmi1)

GAT:	120811832(bmi1a)

PPUG:

119198749(bmi1a)

AFB:	129110838(bmi1a)

CLUM:

117749914(bmi1a)

PSWI:

130206650(bmi1a)

MSAM:

119908659(bmi1a)

SCHU:

122866235(bmi1a)

ALAT:

119008694(bmi1a)

MZE:	101487052(bmi1)

ONL:	100711735(bmi1)

OAU:	116328281(bmi1a)

OLA:

101164762

OML:	112151600(bmi1a)

CSAI:

133423363(bmi1a)

XMA:

XCO:

PRET:

PFOR:

PLAI:

106948849(bmi1)

PMEI:

106919738

GAF:	122823920(bmi1a)

PPRL:

129364689(bmi1a)

CVG:

107092259

CTUL:

119773504(bmi1a)

GMU:	124858512(bmi1a)

NFU:	107382973(bmi1)

KMR:	108243124(bmi1a)

ALIM:

106537046(bmi1)

NWH:	119426640(bmi1a)

AOCE:

111569764(bmi1)

MCEP:

124995977(bmi1a)

CSEM:

103376913(bmi1) 103377013

POV:	109629791(bmi1)

SSEN:

122775599

HHIP:

117754000(bmi1a)

HSP:	118098713(bmi1a)

SMAU:

118291091(bmi1a)

LCF:	108900791(bmi1a)

SDU:	111237241(bmi1)

XGL:	120789836(bmi1a)

HCQ:	109519157(bmi1)

SSCV:

125986323

SBIA:

133493030(bmi1a)

PEE:

PTAO:

BPEC:

MALB:

BSPL:

114854841(bmi1a)

SJO:	128382631(bmi1a)

SASA:

100380496(bmi1a) 106564949 106568664 106578384 106587926

STRU:

115152042 115156570 115195419

OTW:	112215480(bmi1a) 112227664 112245673 112260152 112264444

OMY:	110485908 110489603 110493637 110529973 110535407(bmi1a)

OGO:	123991262(bmi1a) 124039501

ONE:	115105000 115114088 115116299

OKI:	109875041 109899213 109909920

OKE:	118361678(bmi1a) 118381263 118402450

SALP:

111949636 111958358 111972859 111982320

SNH:	120027993(bmi1a) 120036479

CCLU:

121534556 121549778(bmi1a) 121569317

ELS:	105022037(bmi1) 105025009

SFM:	108927998 108940586

PKI:	111837856 111858971

AANG:

118224638(bmi1a) 118233788

LOC:	102689934(bmi1)

PSPA:

121312486 121313753

ARUT:

117394846(bmi1a) 117400107

PSEX:

120530064

LCM:	102360935(BMI1)

CMK:

103176338

RTP:	109934436(bmi1a)

CPLA:

HOC:

LERI:

PMRN:

LRJ:

BFO:

BBEL:

SPU:	115925836 578544

LPIC:

129275147

APLC:

110977726

AJC:

117102938

SKO:	100376114 102809912

DME:	Dmel_CG3886(Psc)

DER:

6546611

DSE:

6608930

DSI:	Dsimw501_GD25796(Dsim_GD25796)

DYA:	Dyak_GE13404

DSR:

DPO:

DPE:

DMN:

DWI:

DMO:	Dmoj_GI19568

DAZ:

DNV:

DHE:

TDA:

MDE:

LCQ:

GFS:

AGA:

ACOZ:

AARA:

AAG:

AALB:

CQU:	CpipJ_CPIJ015235

CPII:

AME:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

CCAL:

OBB:

CGIG:

SOC:	105196584 105196595 105198374

MPHA:

105828771 105838365 105838371

AEC:	105143465 105151241 105151242

ACEP:

105617422 105619425 105619426

PBAR:

105430143 105430144 105430473

VEM:	105559090 105565159 105565160

HST:	105181633 105181676 105182439

DQU:	106742360 106742361 106745151

CFO:	105254603 105257103 105257110

FEX:	115233408 115233809 115233837

LHU:	105669232 105678181 105678196

PGC:	109857456 109859060 109859081

OBO:	105275349 105278376 105278377

PCF:	106786813 106792315

PFUC:

122514684 122521866

VPS:	122634063 122636534

VCRB:

124430530

VVE:	124954395 124956467

NVI:

100116657

CSOL:

105359974 105365537

MDL:

103580374

TCA:	655090 657155

DPA:	109537785 109537790 109543767

SOY:

115876086

ATD:	109603726 109604153 109605306

NVL:	108557045 108559390 108564008

PPYR:

116161511 116161614 116161810

API:	100161947 100162132 100162794

DNX:	107162609 107165828 107165834

AGS:	114123595 114132082 114132694

RMD:	113548284 113548964 113549308

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:	111045222 111059463

HVI:

124363255

ZNE:	110837400 110839216

DPX:	DAPPUDRAFT_302409

DMK:	116918693 116930951

PPOI:

119109678 119109766 119109768

DSV:	119442278 119442758

RSAN:

119387922

RMP:	119159624 119188215

TUT:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

LGI:	LOTGIDRAFT_135291 LOTGIDRAFT_135322 LOTGIDRAFT_56827

PCAN:

112564460 112564767

GAE:	121380777 121381341

HRF:	124110539 124110541

HRJ:	124279262 124279263

CRG:	105347038 105347039

CVN:

111115973

CANU:

128162624

OED:

125666798

MYI:	110445337 110445339 110445340

PMAX:

117343508 117343589 117343809

MCAF:

127730449

MMER:

123531307 123532587 123532960

OBI:	106875343 106878501 106879594

OSN:	115214949 115215012

LAK:	106157368 106157411

SMM:	Smp_089230

OVI:	T265_05717

NVE:	5508486 5515550 5515596

EPA:	110231529 110231535

ATEN:

116305208 116308068 116308072

ADF:	107330743 107330966 107330970 107330971

AMIL:

114955236 114955254 114955335

PDAM:

113679401 113679411 113679416 113679417

SPIS:

111326213 111326237 111326239 111326250

DGT:	114520412 114544812

XEN:

124439915

HMG:

101241434

HSY:

130621712

TAD:	TRIADDRAFT_54995

» show all

Reference

PMID:15976916

Authors

Shakhova O, Leung C, Marino S

Title

Bmi1 in development and tumorigenesis of the central nervous system.

Journal

J Mol Med (Berl) 83:596-600 (2005)
DOI:10.1007/s00109-005-0682-0

Reference

PMID:8268912

Authors

Alkema MJ, Wiegant J, Raap AK, Berns A, van Lohuizen M

Title

Characterization and chromosomal localization of the human proto-oncogene BMI-1.

Journal

Hum Mol Genet 2:1597-603 (1993)
DOI:10.1093/hmg/2.10.1597

Sequence

[hsa:648]

LinkDB

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