| Entry |
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| Name |
3-dehydroquinate synthase II;
DHQ synthase II;
MJ1249 (gene name);
aroB' (gene name)
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| Class |
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD+ oxidoreductase (deaminating)
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| Reaction(IUBMB) |
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+ = 3-dehydroquinate + NH3 + NADH + H+ [RN: R08569]
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| Reaction(KEGG) |
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| Substrate |
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate;
H2O [CPD: C00001];
NAD+ [CPD: C00003]
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| Product |
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| Comment |
The enzyme, which was isolated from the archaeon Methanocaldococcus jannaschii, plays a key role in an alternative pathway for the biosynthesis of 3-dehydroquinate (DHQ), an intermediate of the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme catalyses a two-step reaction - an oxidative deamination, followed by cyclization.
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| History |
EC 1.4.1.24 created 2012
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| Pathway |
| Phenylalanine, tyrosine and tryptophan biosynthesis | | Biosynthesis of secondary metabolites | | Biosynthesis of antibiotics |
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| Orthology |
| 3-dehydroquinate synthase II |
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| Genes |
DEL: | | DVM: | | DVG: | | DDE: | | DDS: | | DDN: | | DMA: | | DSA: | | DAS: | | DAF: | | DHY: | | DPI: | | DGG: | | DFI: | | DEJ: | | DPG: | | DBA: | | DOA: | | DRT: | | SUR: | | DAO: | | AXL: | | HHD: | | SJE: | | AAE: | | HYA: | | HHO: | | HYS: | | HTH: | | HTE: | | TAL: | | TRD: | | SUL: | | SAF: | | PMX: | | TTK: | | TAM: | | DTE: | | MJA: | | MFE: | | MVU: | | MFS: | | MIF: | | MJH: | | MIG: | | MMP: | | MMQ: | | MMX: | | MMZ: | | MMD: | | MMAK: | | MMAO: | | MAE: | | MVN: | | MVO: | | MOK: | | MAC: | | MBA: | | MBY: | | MBW: | | MBAR: | | MBAK: | | MMA: | | MMAZ: | | MMJ: | | MMAC: | | MVC: | | MEK: | | MLS: | | METM: | | MEF: | | MEQ: | | MSJ: | | MSZ: | | MSW: | | MTHE: | | MTHR: | | MHOR: | | MBU: | | MMET: | | MMH: | | MHAZ: | | MEV: | | MZH: | | MPY: | | MHZ: | | MTP: | | MCJ: | | MHI: | | MHU: | | MLA: | | MEM: | | MBG: | | MEMA: | | MPI: | | MBN: | | MFO: | | MPL: | | MPD: | | MEZ: | | RCI: | | MTH: | | MMG: | | METC: | | MWO: | | MST: | | MSI: | | MRU: | | MEB: | | MMIL: | | MEYE: | | MOL: | | MEL: | | MEW: | | METH: | | MFC: | | MFI: | | MCUB: | | MFV: | | MKA: | | AFU: | | AFG: | | APO: | | AVE: | | AST: | | FPL: | | GAC: | | GAH: | | HAL: | | HSL: | | HDL: | | HHB: | | HJE: | | HALH: | | HHSR: | | HMA: | | HHI: | | HHN: | | HAB: | | NPH: | | NMO: | | HUT: | | HTI: | | HMU: | | HALI: | | HSU: | | HSF: | | HWA: | | HWC: | | HVO: | | HME: | | HGI: | | HBO: | | HLA: | | HTU: | | HDA: | | NMG: | | HXA: | | NAT: | | NPE: | | NGE: | | HRU: | | NOU: | | SALI: | | HLR: | | HLC: | | TAR: | | MAX: | | MER: | | MEAR: | | MARC: | | NMR: | | NIR: | | NID: | | NIN: | | NKR: | | NCT: | | CSY: | | NGA: | | NVN: | | NEV: | | TAA: | | CSU: | | NBV: | | TAH: | | NDV: | | KCR: | | BARB: | | LOKI: | | HAH: | |
» show all
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| Reference |
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| Authors |
White RH. |
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| Title |
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii. |
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| Journal |
Biochemistry. 43 (2004) 7618-27. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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