KEGG ORTHOLOGY: K11783

ORTHOLOGY: K11783

Entry

K11783 KO

Name

mqnB

Definition

futalosine hydrolase [EC:3.2.2.26]

Pathway

ko00130

Ubiquinone and other terpenoid-quinone biosynthesis

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Metabolism of cofactors and vitamins
   00130 Ubiquinone and other terpenoid-quinone biosynthesis
    K11783  mqnB; futalosine hydrolase
Enzymes [BR:ko01000]
3. Hydrolases
  3.2  Glycosylases
   3.2.2  Hydrolysing N-glycosyl compounds
    3.2.2.26  futalosine hydrolase
     K11783  mqnB; futalosine hydrolase

Other DBs

RN:

R08587

Genes

AQL:	BXU06_16280
GSU:	GSU0453(mqnB)
GSK:	KN400_0426(mqnB)
GME:	Gmet_3381(mqnB)
GUR:	Gura_0685
GLO:	Glov_0458
GBM:	Gbem_0598(mqnB)
GEO:	Geob_0898(mqnB)
GEM:	GM21_0612
GEB:	GM18_3755
GPI:	GPICK_15470
GAO:	A2G06_02095
PCA:	Pcar_3117(mqnB)
PPD:	Ppro_3274
PACE:	A6070_00960
PEF:	A7E78_09160
DES:	DSOUD_0020(mqnB)
DEU:	DBW_3613
DVU:	DVU3178
DVL:	Dvul_0209
DVM:	DvMF_2491
DVG:	Deval_2935
DDE:	Dde_3188
DDS:	Ddes_1911
DDN:	DND132_1764
DMA:	DMR_35800
DSA:	Desal_0762
DAS:	Daes_0800
DAF:	Desaf_1765
DHY:	DESAM_20138
DPI:	BN4_11672
DGG:	DGI_2626
DFI:	AXF13_00485
DEJ:	AWY79_05195
DPG:	DESPIGER_1540
DBA:	Dbac_3009
DOA:	AXF15_03675
DRT:	Dret_2414
DAK:	DaAHT2_0723
DPR:	Despr_2780
DSF:	UWK_02144
DOL:	Dole_1278
DML:	Dmul_05540
DAT:	HRM2_27040
DTO:	TOL2_C37140
VIN:	AKJ08_0247
LLU:	AKJ09_04863
SFU:	Sfum_1814
DBR:	Deba_2375
BHA:	BH2690
BCL:	ABC0988
BPF:	BpOF4_09540
BCO:	Bcell_0852
BLE:	BleG1_0976
FPN:	ABE65_001850
FAR:	ABE41_001800
BSE:	Bsel_0478
BBE:	BBR47_09530
BLR:	BRLA_c006120
PJD:	Pjdr2_0345
GYM:	GYMC10_1380
PPY:	PPE_03890
PPM:	PPSC2_20425
PPO:	PPM_4092(M1_4500)
PPOL:	X809_36560
PPQ:	PPSQR21_041300
PPOY:	RE92_16780
PMS:	KNP414_07865
PMQ:	PM3016_7383
PMW:	B2K_40540
PTA:	HPL003_01395
PLV:	ERIC2_c17880
PSAB:	PSAB_23170
PDU:	PDUR_26390
PBD:	PBOR_34495
PGM:	PGRAT_30845
POD:	PODO_29285
PAEN:	P40081_35815
PAEF:	R50345_29395
PAEQ:	R50912_32460
PSTE:	PSTEL_25845
PAEA:	R70723_31260
PAEE:	R70331_30025
PAEH:	H70357_33555
PAEJ:	H70737_29040
PBJ:	VN24_21955
PIH:	UB51_10820
PRI:	PRIO_6458
PPEO:	ABE82_20475
PNP:	IJ22_04090
POW:	IJ21_28570
PBV:	AR543_07275
PXL:	BS614_09385
PYG:	AWM70_01080
PSWU:	SY83_01250
TCO:	Theco_3963
ANX:	ACH33_15920
TUM:	CBW65_09890
DRM:	Dred_3235
DAE:	Dtox_4200
DGI:	Desgi_0052
DAU:	Daud_0261
TJR:	TherJR_0139
SGY:	Sgly_3170
DOR:	Desor_0800
DMI:	Desmer_0821
SCO:	SCO4327(SCD12A.10c)
SMA:	SAV_3905
SGR:	SGR_3174
SGB:	WQO_19855
SCB:	SCAB_50841
SSX:	SACTE_3764
SVL:	Strvi_8732
SCT:	SCAT_2423
SCY:	SCATT_24070
SFA:	Sfla_2741
SBH:	SBI_04915
SHY:	SHJG_4799
SHO:	SHJGH_4562
SVE:	SVEN_4139
SDV:	BN159_4910
SALB:	XNR_2324
SALS:	SLNWT_0701 SLNWT_4242
STRP:	F750_4057
SFI:	SFUL_4158
SCI:	B446_17345
SRC:	M271_28000
SALU:	DC74_4819
SALL:	SAZ_25775
SLV:	SLIV_16760(mqnB)
SGU:	SGLAU_15280
SVT:	SVTN_21500
STRE:	GZL_04008
SCW:	TU94_18475
SLD:	T261_3374
SXI:	SXIM_32090
STRM:	M444_16080
STRC:	AA958_13265
SAMB:	SAM23877_3378(mqnB)
SPRI:	SPRI_4149
SCZ:	ABE83_15455
SCX:	AS200_25570
SRW:	TUE45_04208(mqnB)
STRF:	ASR50_18675
SLE:	sle_39460(sle_39460)
SRN:	A4G23_02416(mqnB)
SPAV:	Spa2297_14655
SLC:	SL103_32125
STRT:	A8713_13720
SCLF:	BB341_12075
SGS:	AVL59_44750
STSI:	A4E84_17895
SLS:	SLINC_3823
SNR:	SNOUR_17860
SPLU:	LK06_018400
STRD:	NI25_21950
SNW:	BBN63_19240
KSK:	KSE_44340
FRA:	Francci3_4421
FRE:	Franean1_0152
FRI:	FraEuI1c_0099
FAL:	FRAAL6734
FSY:	FsymDg_0158
ACE:	Acel_0106
STP:	Strop_0412
SAQ:	Sare_0500
MAU:	Micau_0503
MIL:	ML5_0694
VMA:	VAB18032_06575
AMS:	AMIS_3780
ASE:	ACPL_536
ACTN:	L083_0510
AFS:	AFR_02110
CAI:	Caci_8090
SNA:	Snas_5857
DRA:	DR_1664
DGE:	Dgeo_0447
DDR:	Deide_07551
DMR:	Deima_0691
DPT:	Deipr_0614
DGO:	DGo_CA1229
DPD:	Deipe_0942
DSW:	QR90_12330
DCH:	SY84_12885
DAB:	AUC44_11995
DPU:	SU48_04135
TRA:	Trad_1280
TTH:	TT_C0188
TTJ:	TTHA0556
TTS:	Ththe16_0556
TTL:	TtJL18_1519
TSC:	TSC_c08340
THC:	TCCBUS3UF1_9240
TOS:	Theos_0782
TAQ:	TO73_1348
TPAR:	AV541_07910
TBC:	A0O31_01992(mqnB)
MRB:	Mrub_0986
MRE:	K649_04570
MSV:	Mesil_1255
OPR:	Ocepr_2008
MHD:	Marky_0101
RBA:	RB1081
PIR:	VN12_00835(mqnB)
FMR:	Fuma_02702
CTM:	Cabther_A0064
ABAC:	LuPra_05981
FSU:	Fisuc_1888
FSC:	FSU_2393
GPH:	GEMMAAP_16935
BACC:	BRDCF_p520
RBC:	BN938_0240
DORI:	FH5T_01435
BLQ:	L21SP5_03128
CPI:	Cpin_6958
NKO:	Niako_5078
NSO:	NIASO_19250
NIA:	A8C56_01805
FLA:	SY85_08220
ARB:	A9P82_12565
HHY:	Halhy_0301
SGN:	SGRA_1216(mtnN)
PHE:	Phep_4151
PEP:	AQ505_01225
PCM:	AY601_4379
PSTY:	BFS30_06115
PSN:	Pedsa_2886
SHG:	Sph21_1320
SHT:	KO02_00760
SPHN:	BV902_01150
SCN:	Solca_4157
MUP:	A0256_04250
TTK:	TST_1334(mtnN)
DIN:	Selin_1732
DDF:	DEFDS_1229
DAP:	Dacet_1934
CNI:	Calni_1363
FSI:	Flexsi_1429
TYE:	THEYE_A0852
TID:	Thein_1289
TOP:	TOPB45_0116
TCM:	HL41_06220
CTHI:	THC_1277

» show all

Reference

PMID:18801996

Authors

Hiratsuka T, Furihata K, Ishikawa J, Yamashita H, Itoh N, Seto H, Dairi T

Title

An alternative menaquinone biosynthetic pathway operating in microorganisms.

Journal

Science 321:1670-3 (2008)
DOI:10.1126/science.1160446

Sequence

[sco:SCO4327] [ttj:TTHA0556]

LinkDB

ENZYME: 3.2.2.26

Entry

EC 3.2.2.26 Enzyme

Name

futalosine hydrolase;
futalosine nucleosidase;
MqnB

Class

Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds

Sysname

futalosine ribohydrolase

Reaction(IUBMB)

futalosine + H2O = dehypoxanthine futalosine + hypoxanthine [RN:R08587]

Reaction(KEGG)

R08587

Substrate

futalosine [CPD:C16999];
H2O [CPD:C00001]

Product

dehypoxanthine futalosine [CPD:C17010];
hypoxanthine [CPD:C00262]

Comment

This enzyme, which is specific for futalosine, catalyses the second step of a novel menaquinone biosynthetic pathway that is found in some prokaryotes.

History

EC 3.2.2.26 created 2008

Pathway

ec00130	Ubiquinone and other terpenoid-quinone biosynthesis
ec01110	Biosynthesis of secondary metabolites

Orthology

K11783

futalosine hydrolase

Genes

AQL:	BXU06_16280
GSU:	GSU0453(mqnB)
GSK:	KN400_0426(mqnB)
GME:	Gmet_3381(mqnB)
GUR:	Gura_0685
GLO:	Glov_0458
GBM:	Gbem_0598(mqnB)
GEO:	Geob_0898(mqnB)
GEM:	GM21_0612
GEB:	GM18_3755
GPI:	GPICK_15470
GAO:	A2G06_02095
PCA:	Pcar_3117(mqnB)
PPD:	Ppro_3274
PACE:	A6070_00960
PEF:	A7E78_09160
DES:	DSOUD_0020(mqnB)
DEU:	DBW_3613
DVU:	DVU3178
DVL:	Dvul_0209
DVM:	DvMF_2491
DVG:	Deval_2935
DDE:	Dde_3188
DDS:	Ddes_1911
DDN:	DND132_1764
DMA:	DMR_35800
DSA:	Desal_0762
DAS:	Daes_0800
DAF:	Desaf_1765
DHY:	DESAM_20138
DPI:	BN4_11672
DGG:	DGI_2626
DFI:	AXF13_00485
DEJ:	AWY79_05195
DPG:	DESPIGER_1540
DBA:	Dbac_3009
DOA:	AXF15_03675
DRT:	Dret_2414
DAK:	DaAHT2_0723
DPR:	Despr_2780
DSF:	UWK_02144
DOL:	Dole_1278
DML:	Dmul_05540
DAT:	HRM2_27040
DTO:	TOL2_C37140
VIN:	AKJ08_0247
LLU:	AKJ09_04863
SFU:	Sfum_1814
DBR:	Deba_2375
BHA:	BH2690
BCL:	ABC0988
BPF:	BpOF4_09540
BCO:	Bcell_0852
BLE:	BleG1_0976
FPN:	ABE65_001850
FAR:	ABE41_001800
BSE:	Bsel_0478
BBE:	BBR47_09530
BLR:	BRLA_c006120
PJD:	Pjdr2_0345
GYM:	GYMC10_1380
PPY:	PPE_03890
PPM:	PPSC2_20425
PPO:	PPM_4092(M1_4500)
PPOL:	X809_36560
PPQ:	PPSQR21_041300
PPOY:	RE92_16780
PMS:	KNP414_07865
PMQ:	PM3016_7383
PMW:	B2K_40540
PTA:	HPL003_01395
PLV:	ERIC2_c17880
PSAB:	PSAB_23170
PDU:	PDUR_26390
PBD:	PBOR_34495
PGM:	PGRAT_30845
POD:	PODO_29285
PAEN:	P40081_35815
PAEF:	R50345_29395
PAEQ:	R50912_32460
PSTE:	PSTEL_25845
PAEA:	R70723_31260
PAEE:	R70331_30025
PAEH:	H70357_33555
PAEJ:	H70737_29040
PBJ:	VN24_21955
PIH:	UB51_10820
PRI:	PRIO_6458
PPEO:	ABE82_20475
PNP:	IJ22_04090
POW:	IJ21_28570
PBV:	AR543_07275
PXL:	BS614_09385
PYG:	AWM70_01080
PSWU:	SY83_01250
TCO:	Theco_3963
ANX:	ACH33_15920
TUM:	CBW65_09890
DRM:	Dred_3235
DAE:	Dtox_4200
DGI:	Desgi_0052
DAU:	Daud_0261
TJR:	TherJR_0139
SGY:	Sgly_3170
DOR:	Desor_0800
DMI:	Desmer_0821
SCO:	SCO4327(SCD12A.10c)
SMA:	SAV_3905
SGR:	SGR_3174
SGB:	WQO_19855
SCB:	SCAB_50841
SSX:	SACTE_3764
SVL:	Strvi_8732
SCT:	SCAT_2423
SCY:	SCATT_24070
SFA:	Sfla_2741
SBH:	SBI_04915
SHY:	SHJG_4799
SHO:	SHJGH_4562
SVE:	SVEN_4139
SDV:	BN159_4910
SALB:	XNR_2324
SALS:	SLNWT_0701 SLNWT_4242
STRP:	F750_4057
SFI:	SFUL_4158
SCI:	B446_17345
SRC:	M271_28000
SALU:	DC74_4819
SALL:	SAZ_25775
SLV:	SLIV_16760(mqnB)
SGU:	SGLAU_15280
SVT:	SVTN_21500
STRE:	GZL_04008
SCW:	TU94_18475
SLD:	T261_3374
SXI:	SXIM_32090
STRM:	M444_16080
STRC:	AA958_13265
SAMB:	SAM23877_3378(mqnB)
SPRI:	SPRI_4149
SCZ:	ABE83_15455
SCX:	AS200_25570
SRW:	TUE45_04208(mqnB)
STRF:	ASR50_18675
SLE:	sle_39460(sle_39460)
SRN:	A4G23_02416(mqnB)
SPAV:	Spa2297_14655
SLC:	SL103_32125
STRT:	A8713_13720
SCLF:	BB341_12075
SGS:	AVL59_44750
STSI:	A4E84_17895
SLS:	SLINC_3823
SNR:	SNOUR_17860
SPLU:	LK06_018400
STRD:	NI25_21950
SNW:	BBN63_19240
KSK:	KSE_44340
FRA:	Francci3_4421
FRE:	Franean1_0152
FRI:	FraEuI1c_0099
FAL:	FRAAL6734
FSY:	FsymDg_0158
ACE:	Acel_0106
STP:	Strop_0412
SAQ:	Sare_0500
MAU:	Micau_0503
MIL:	ML5_0694
VMA:	VAB18032_06575
AMS:	AMIS_3780
ASE:	ACPL_536
ACTN:	L083_0510
AFS:	AFR_02110
CAI:	Caci_8090
SNA:	Snas_5857
DRA:	DR_1664
DGE:	Dgeo_0447
DDR:	Deide_07551
DMR:	Deima_0691
DPT:	Deipr_0614
DGO:	DGo_CA1229
DPD:	Deipe_0942
DSW:	QR90_12330
DCH:	SY84_12885
DAB:	AUC44_11995
DPU:	SU48_04135
TRA:	Trad_1280
TTH:	TT_C0188
TTJ:	TTHA0556
TTS:	Ththe16_0556
TTL:	TtJL18_1519
TSC:	TSC_c08340
THC:	TCCBUS3UF1_9240
TOS:	Theos_0782
TAQ:	TO73_1348
TPAR:	AV541_07910
TBC:	A0O31_01992(mqnB)
MRB:	Mrub_0986
MRE:	K649_04570
MSV:	Mesil_1255
OPR:	Ocepr_2008
MHD:	Marky_0101
RBA:	RB1081
PIR:	VN12_00835(mqnB)
FMR:	Fuma_02702
CTM:	Cabther_A0064
ABAC:	LuPra_05981
FSU:	Fisuc_1888
FSC:	FSU_2393
GPH:	GEMMAAP_16935
BACC:	BRDCF_p520
RBC:	BN938_0240
DORI:	FH5T_01435
BLQ:	L21SP5_03128
CPI:	Cpin_6958
NKO:	Niako_5078
NSO:	NIASO_19250
NIA:	A8C56_01805
FLA:	SY85_08220
ARB:	A9P82_12565
HHY:	Halhy_0301
SGN:	SGRA_1216(mtnN)
PHE:	Phep_4151
PEP:	AQ505_01225
PCM:	AY601_4379
PSTY:	BFS30_06115
PSN:	Pedsa_2886
SHG:	Sph21_1320
SHT:	KO02_00760
SPHN:	BV902_01150
SCN:	Solca_4157
MUP:	A0256_04250
TTK:	TST_1334(mtnN)
DIN:	Selin_1732
DDF:	DEFDS_1229
DAP:	Dacet_1934
CNI:	Calni_1363
FSI:	Flexsi_1429
TYE:	THEYE_A0852
TID:	Thein_1289
TOP:	TOPB45_0116
TCM:	HL41_06220
CTHI:	THC_1277