KEGG   ORTHOLOGY: K11820Help
Entry
K11820                      KO                                     

Name
UGT74B1
Definition
N-hydroxythioamide S-beta-glucosyltransferase [EC:2.4.1.195]
Pathway
Tryptophan metabolism
Glucosinolate biosynthesis
2-Oxocarboxylic acid metabolism
Module
M00370  
Glucosinolate biosynthesis, tryptophan => glucobrassicin
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01210 2-Oxocarboxylic acid metabolism
    K11820  UGT74B1; N-hydroxythioamide S-beta-glucosyltransferase
  Amino acid metabolism
   00380 Tryptophan metabolism
    K11820  UGT74B1; N-hydroxythioamide S-beta-glucosyltransferase
  Biosynthesis of other secondary metabolites
   00966 Glucosinolate biosynthesis
    K11820  UGT74B1; N-hydroxythioamide S-beta-glucosyltransferase
KEGG modules [BR:ko00002]
 Pathway module
  Secondary metabolism
   Biosynthesis of secondary metabolites
    M00370  Glucosinolate biosynthesis, tryptophan => glucobrassicin
     K11820  UGT74B1; N-hydroxythioamide S-beta-glucosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.195  N-hydroxythioamide S-beta-glucosyltransferase
     K11820  UGT74B1; N-hydroxythioamide S-beta-glucosyltransferase
Glycosyltransferases [BR:ko01003]
 Others
  Hydrophobic molecule
   K11820  UGT74B1; N-hydroxythioamide S-beta-glucosyltransferase
BRITE hierarchy
Other DBs
Genes
RSS: 
ATH: 
AT1G24100(UGT74B1)
ALY: 
CRB: 
EUS: 
BRP: 
103840711(UGT74B1-1)
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
18603841 18609376
GRA: 
105766111 105785553 105789117
GHI: 
107903698 107916109 107922512 107957313 107963785
EGR: 
104427824 104432928
GMX: 
100787855 100805508 100806069
PVU: 
PHAVU_002G075200g
VRA: 
106754697
VAR: 
108334879
CCAJ: 
109800656 109801468
MTR: 
MTR_5g035560 MTR_5g035580
CAM: 
101500102
ADU: 
107488943 107491373
AIP: 
107643497 107643933
LJA: 
Lj2g3v1371330.1(Lj2g3v1371330.1)
LANG: 
109330572 109332223
FVE: 
101294357 101298891 101308673
PPER: 
18776421 18794038
PMUM: 
103338304 103343266
MDM: 
103425490 103455316
ZJU: 
107418463 107419884 107419915 107419916
RCU: 
8270386
JCU: 
105640428 105649838
POP: 
POPTR_0015s08330g(POPTRDRAFT_666418)
VVI: 
100260341 100260432
SLY: 
101251379
SPEN: 
107019146 107019181
SOT: 
102603088 102603422
INI: 
109154647 109154662
SIND: 
105168211
BVG: 
104894392 104905872 104908451
BDI: 
100835161
ATR: 
18448709
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Grubb CD, Zipp BJ, Ludwig-Muller J, Masuno MN, Molinski TF, Abel S
  Title
Arabidopsis glucosyltransferase UGT74B1 functions in glucosinolate biosynthesis and auxin homeostasis.
  Journal
Plant J 40:893-908 (2004)
DOI:10.1111/j.1365-313X.2004.02261.x
  Sequence
[ath:AT1G24100]
LinkDB All DBs

KEGG   ENZYME: 2.4.1.195Help
Entry
EC 2.4.1.195                Enzyme                                 

Name
N-hydroxythioamide S-beta-glucosyltransferase;
desulfoglucosinolate-uridine diphosphate glucosyltransferase;
uridine diphosphoglucose-thiohydroximate glucosyltransferase;
thiohydroximate beta-D-glucosyltransferase;
UDPG:thiohydroximate glucosyltransferase;
thiohydroximate S-glucosyltransferase;
thiohydroximate glucosyltransferase;
UDP-glucose:thiohydroximate S-beta-D-glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-glucose:N-hydroxy-2-phenylethanethioamide S-beta-D-glucosyltransferase
Reaction(IUBMB)
UDP-glucose + N-hydroxy-2-phenylethanethioamide = UDP + desulfoglucotropeolin [RN:R03213]
Reaction(KEGG)
Substrate
UDP-glucose [CPD:C00029];
N-hydroxy-2-phenylethanethioamide
Product
UDP [CPD:C00015];
desulfoglucotropeolin [CPD:C01069]
Comment
Involved with EC 2.8.2.24, desulfoglucosinolate sulfotransferase, in the biosynthesis of thioglucosides in cruciferous plants.
History
EC 2.4.1.195 created 1992, modified 2006
Pathway
Tryptophan metabolism
Glucosinolate biosynthesis
Biosynthesis of secondary metabolites
Orthology
K11820  
N-hydroxythioamide S-beta-glucosyltransferase
Genes
RSS: 
ATH: 
AT1G24100(UGT74B1)
ALY: 
CRB: 
EUS: 
BRP: 
103840711(UGT74B1-1)
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
18603841 18609376
GRA: 
105766111 105785553 105789117
GHI: 
107903698 107916109 107922512 107957313 107963785
EGR: 
104427824 104432928
GMX: 
100787855 100805508 100806069
PVU: 
PHAVU_002G075200g
VRA: 
106754697
VAR: 
108334879
CCAJ: 
109800656 109801468
MTR: 
MTR_5g035560 MTR_5g035580
CAM: 
101500102
ADU: 
107488943 107491373
AIP: 
107643497 107643933
LJA: 
Lj2g3v1371330.1(Lj2g3v1371330.1)
LANG: 
109330572 109332223
FVE: 
101294357 101298891 101308673
PPER: 
18776421 18794038
PMUM: 
103338304 103343266
MDM: 
103425490 103455316
ZJU: 
107418463 107419884 107419915 107419916
RCU: 
8270386
JCU: 
105640428 105649838
POP: 
POPTR_0015s08330g(POPTRDRAFT_666418)
VVI: 
100260341 100260432
SLY: 
101251379
SPEN: 
107019146 107019181
SOT: 
102603088 102603422
INI: 
109154647 109154662
SIND: 
105168211
BVG: 
104894392 104905872 104908451
BDI: 
100835161
ATR: 
18448709
 » show all
Taxonomy
Reference
1  [PMID:2524977]
  Authors
Jain JC, Reed DW, GrootWassink JW, Underhill EW.
  Title
A radioassay of enzymes catalyzing the glucosylation and sulfation steps of glucosinolate biosynthesis in Brassica species.
  Journal
Anal. Biochem. 178 (1989) 137-40.
Reference
2  [PMID:8373190]
  Authors
Reed DW, Davin L, Jain JC, Deluca V, Nelson L, Underhill EW.
  Title
Purification and properties of UDP-glucose:thiohydroximate glucosyltransferase from Brassica napus L. seedlings.
  Journal
Arch. Biochem. Biophys. 305 (1993) 526-32.
Reference
3  [PMID:11198818]
  Authors
Fahey JW, Zalcmann AT, Talalay P.
  Title
The chemical diversity and distribution of glucosinolates and isothiocyanates among plants.
  Journal
Phytochemistry. 56 (2001) 5-51.
Reference
4
  Authors
Grubb, C.D., Zipp, B.J., Ludwig-Muller, J., Masuno, M.N., Molinski, T.F. and Abel, S.
  Title
Arabidopsis glucosyltransferase UGT74B1 functions in glucosinolate biosynthesis and auxin homeostasis.
  Journal
Plant J. 40 (2004) 893-908.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9068-14-8
LinkDB All DBs

KEGG   REACTION: R03213Help
Entry
R03213                      Reaction                               

Name
UDPglucose:thiohydroximate S-beta-D-glucosyltransferase
Definition
UDP-glucose + Phenylacetothiohydroximate <=> UDP + Desulfoglucotropeolin
Equation
Reaction class
C00015_C00029
C01069_C03719
Enzyme
Pathway
Glucosinolate biosynthesis
Biosynthesis of secondary metabolites
2-Oxocarboxylic acid metabolism
Orthology
K11820  
N-hydroxythioamide S-beta-glucosyltransferase [EC:2.4.1.195]
LinkDB All DBs

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