KEGG   ORTHOLOGY: K13066Help
Entry
K13066                      KO                                     

Name
E2.1.1.68, COMT
Definition
caffeic acid 3-O-methyltransferase [EC:2.1.1.68]
Pathway
Phenylpropanoid biosynthesis
Module
M00039  
Monolignol biosynthesis, phenylalanine/tyrosine  => monolignol
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Biosynthesis of other secondary metabolites
   00940 Phenylpropanoid biosynthesis
    K13066  E2.1.1.68, COMT; caffeic acid 3-O-methyltransferase
KEGG modules [BR:ko00002]
 Pathway module
  Secondary metabolism
   Biosynthesis of secondary metabolites
    M00039  Monolignol biosynthesis, phenylalanine / tyrosine  => monolignol
     K13066  E2.1.1.68, COMT; caffeic acid 3-O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.68  caffeate O-methyltransferase
     K13066  E2.1.1.68, COMT; caffeic acid 3-O-methyltransferase
BRITE hierarchy
Other DBs
Genes
RSS: 
ATH: 
AT5G54160(OMT1)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
CICLE_v10001555mg CICLE_v10001661mg CICLE_v10003181mg CICLE_v10003323mg CICLE_v10003428mg CICLE_v10003445mg CICLE_v10003534mg CICLE_v10003737mg CICLE_v10005230mg CICLE_v10005251mg CICLE_v100108602m CICLE_v10012042mg CICLE_v10013542mg CICLE_v10015685mg CICLE_v10017649mg CICLE_v10017683mg CICLE_v10018226mg CICLE_v10018306mg CICLE_v10020377mg CICLE_v10020761mg CICLE_v100208141m CICLE_v100208142m CICLE_v10020820mg CICLE_v10020821mg CICLE_v10020828mg CICLE_v10020870mg CICLE_v10020873mg CICLE_v10020874mg CICLE_v10020875mg CICLE_v10020880mg CICLE_v10021670mg CICLE_v10021888mg CICLE_v10023459mg CICLE_v10023568mg CICLE_v10023965mg CICLE_v10023994mg CICLE_v10024037mg CICLE_v10024098mg CICLE_v10024389mg CICLE_v10026359mg CICLE_v10026361mg CICLE_v10031949mg CICLE_v10031951mg CICLE_v10031952mg CICLE_v10031953mg
TCC: 
108661886 108663133 18507240 18587033 18589881 18589884 18592353 18599823 18599828 18601594 18605869 18605934
GRA: 
105763982 105765366 105765367 105765368 105765408 105767646 105777756 105778083 105778084 105782479 105786164 105791250 105792628 105792629 105793470 105799382
GHI: 
107889315 107889317 107891421 107893152 107895385 107895907 107909353 107915194 107915880 107922183 107923436 107929578 107929579 107929580 107936289 107936296 107937281 107937285 107939017 107940407 107940414 107940417 107947186 107948794
EGR: 
104415145 104415146 104416154 104416156 104416158 104416159 104417513 104420045 104424243 104424567 104429247 104429248 104430455 104430810 104430849 104437195 104437201 104437219 104439341 104444139 104445600 104445601 104447137 104449485 104449526 104449528 104450510 104452413 104452416 104455705 104455715 104456234
GMX: 
100777636 100779492 100780100 100788873 100789402 100793053 100803633 106794104
PVU: 
PHAVU_003G006000g PHAVU_003G006100g PHAVU_009G044400g PHAVU_009G2586001 PHAVU_009G258700g PHAVU_009G258800g PHAVU_009G258900g PHAVU_009G259000g PHAVU_009G259100g PHAVU_009G259200g PHAVU_009G259300g PHAVU_009G259500g PHAVU_010G120200g PHAVU_L008600g
VRA: 
106753579 106760166 106760167 106760169 106764425 106766344 106778175
VAR: 
108322235 108322321 108322322 108331569 108332176 108335252 108337604 108346436 108347163
CCAJ: 
109787879 109787883 109789130 109789134 109792349 109792579 109792971 109793411 109793604 109794407 109797150 109797532 109806421 109817813 109817907
MTR: 
MTR_0591s0010 MTR_1g036460 MTR_1g036490 MTR_1g036510 MTR_1g050220 MTR_3g092900 MTR_5g098170 MTR_6g078850 MTR_7g118300 MTR_7g118320 MTR_8g024160 MTR_8g068570 MTR_8g068600 MTR_8g068690 MTR_8g068730 MTR_8g068740 MTR_8g068750 MTR_8g068870
CAM: 
101489645 101492092 101499314 101499972 101500319 101512074 101512403 101513904 101514542 101514683
ADU: 
107458024 107458050 107458053 107458054 107470102 107471785 107471786 107471788 107471789 107471790 107473073 107473077 107479743
AIP: 
107606820 107606821 107609676 107621172 107622469 107622470 107622471 107622472 107622473 107622793 107624476 107626705 107643318
LJA: 
Lj0g3v0105429.1(Lj0g3v0105429.1) Lj0g3v0124669.1(Lj0g3v0124669.1) Lj0g3v0273599.1(Lj0g3v0273599.1) Lj0g3v0306659.1(Lj0g3v0306659.1) Lj0g3v0346019.1(Lj0g3v0346019.1) Lj0g3v0354359.1(Lj0g3v0354359.1) Lj0g3v0364049.1(Lj0g3v0364049.1) Lj1g3v1079700.1(Lj1g3v1079700.1) Lj1g3v5060810.1(Lj1g3v5060810.1) Lj1g3v5060810.2(Lj1g3v5060810.2) Lj2g3v3339490.1(Lj2g3v3339490.1)
LANG: 
109328338 109329832 109329833 109338233 109343467 109345737 109345738 109355876 109359349 109359350
FVE: 
101292538 101294295 101296734 101308514
PPER: 
18776084 18784868 18786300 18786738 18786962 18787303 18790301
PMUM: 
103319810 103322531 103333559 103342357 103342358 103342359(OMT1) 103342360 103343871
MDM: 
103405809 103406240 103406241 103406249 103410332 103410396 103411915 103416301 103416926 103419371 103420798 103420847 103421923(OMT2) 103422036 103426402 103426499 103426529(omt1) 103426534 103428516 103428558 103429450 103429452 103431087 103431107 103433538 103439452 103439955 103439956 103439958 103443723(omt2) 103444096 103444340(OMT6) 103445678 108172651
PXB: 
103927980 103927981 103927983 103935025 103935026 103943351 103943352 103943506 103951568 103951571 103951572 103951578 103951641 103956347
ZJU: 
107414981 107414982 107418646 107418647 107418657 107418658 107418659 107423770 107423771 107423773 107423786 107423795 107429106 107429761 107434023
CSV: 
101204109 101205290 101210788 101214675 101214916
CMO: 
103491014 103491140 103501180 103503246 107990280 107990972
RCU: 
8270912 8270961 8270962 8282965 8285506 8288877
JCU: 
105631282 105631656 105632993 105634486 105635097 105635102 105635946 105636072 105639044 105639046 105641383 105642764 105645484 105646425 105646969 110009243
POP: 
POPTR_0001s45530g(POPTRDRAFT_550470) POPTR_0002s07730g POPTR_0002s18120g POPTR_0002s18130g POPTR_0002s18150g(POPTRDRAFT_552360) POPTR_0002s18160g(POPTRDRAFT_799151) POPTR_0005s20630g POPTR_0011s15360g(POPTRDRAFT_806142) POPTR_0012s00670g(POPTRDRAFT_834247) POPTR_0014s10210g(POPTRDRAFT_774571) POPTR_0014s10220g(POPTRDRAFT_731466) POPTR_0015s00550g(POPTRDRAFT_824484) POPTR_0016s10450g POPTR_0019s11400g
VVI: 
100232862 100232921(COMT) 100242108 100253843 100255690 100260649 100260763 100260786 100265976 100265990 100854172
SLY: 
101247834 101251452 101258157 101261963(CTOMT1) 101262824
SPEN: 
107002798 107015050 107021224 107022387 107022691 107023557 107023901
SOT: 
102579211 102580081 102590869 102598963 102599285 102599938 102601059 102601955 107058365
INI: 
109150685 109165820 109165828 109169365 109169372 109169378 109169387 109194027
SIND: 
105155388 105155389 105155459 105155461 105156074 105160270 105166789 105166790 105166791 105166792 105166793 105171204 105176053
BVG: 
104887972 104888149 104888150 104888557 104897755 104901566 104901641 104901795 104901881 104901967 104902057 104902142 104902234 104907961 104908865
NNU: 
104585771 104590656 104590659 104596816 104600131 104601399 104604834
DOSA: 
Os04t0175900-01(Os04g0175900) Os12t0199500-00(Os12g0199500) Os12t0202700-00(Os12g0202700) Os12t0240900-00(Os12g0240900)
OBR: 
102717362 102719765
BDI: 
100833782 100838174 100842290
ATS: 
F775_06936 F775_07800 F775_07801 F775_10047 F775_14227 F775_17739 F775_18115 F775_20925 F775_26153 F775_26154 F775_31276 F775_32449
ZMA: 
100125646(comt) 103640406
SITA: 
101754689 101761321 101765311 101772386
PDA: 
103696092 103706414 103716997
EGU: 
105037617 105042923 105054950 105054951 105054993 105054994
MUS: 
103971889 103971898 103971905 103971914 103971925 103971934 103971944 103971953 103971962 103972218 103972714 103973475 103973830 103973864 103973874 103973932 103974217 103974740 103974741 103974791 103974925 103975177 103978658 103980348 103982815 103998763 103998764 103998765 103999438 104000428
ATR: 
18424568
SMO: 
SELMODRAFT_112597 SELMODRAFT_124122 SELMODRAFT_124205 SELMODRAFT_134942 SELMODRAFT_134972 SELMODRAFT_227279 SELMODRAFT_227505 SELMODRAFT_3189 SELMODRAFT_3192 SELMODRAFT_450945(COMT1-2) SELMODRAFT_76630 SELMODRAFT_78541 SELMODRAFT_83100 SELMODRAFT_85724 SELMODRAFT_85878 SELMODRAFT_94918 SELMODRAFT_96831 SELMODRAFT_97635
PPP: 
PHYPADRAFT_175146 PHYPADRAFT_182345
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Zubieta C, Kota P, Ferrer JL, Dixon RA, Noel JP
  Title
Structural basis for the modulation of lignin monomer methylation by caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase.
  Journal
Plant Cell 14:1265-77 (2002)
DOI:10.1105/tpc.001412
  Sequence
LinkDB All DBs

KEGG   ENZYME: 2.1.1.68Help
Entry
EC 2.1.1.68                 Enzyme                                 

Name
caffeate O-methyltransferase;
caffeate methyltransferase;
caffeate 3-O-methyltransferase;
S-adenosyl-L-methionine:caffeic acid-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate [RN:R03366]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3,4-dihydroxy-trans-cinnamate [CPD:C01197]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
3-methoxy-4-hydroxy-trans-cinnamate [CPD:C01494]
Comment
3,4-Dihydroxybenzaldehyde and catechol can act as acceptors, but more slowly.
History
EC 2.1.1.68 created 1984
Pathway
Phenylpropanoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K13066  
caffeic acid 3-O-methyltransferase
Genes
RSS: 
ATH: 
AT5G54160(OMT1)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
CICLE_v10001555mg CICLE_v10001661mg CICLE_v10003181mg CICLE_v10003323mg CICLE_v10003428mg CICLE_v10003445mg CICLE_v10003534mg CICLE_v10003737mg CICLE_v10005230mg CICLE_v10005251mg CICLE_v100108602m CICLE_v10012042mg CICLE_v10013542mg CICLE_v10015685mg CICLE_v10017649mg CICLE_v10017683mg CICLE_v10018226mg CICLE_v10018306mg CICLE_v10020377mg CICLE_v10020761mg CICLE_v100208141m CICLE_v100208142m CICLE_v10020820mg CICLE_v10020821mg CICLE_v10020828mg CICLE_v10020870mg CICLE_v10020873mg CICLE_v10020874mg CICLE_v10020875mg CICLE_v10020880mg CICLE_v10021670mg CICLE_v10021888mg CICLE_v10023459mg CICLE_v10023568mg CICLE_v10023965mg CICLE_v10023994mg CICLE_v10024037mg CICLE_v10024098mg CICLE_v10024389mg CICLE_v10026359mg CICLE_v10026361mg CICLE_v10031949mg CICLE_v10031951mg CICLE_v10031952mg CICLE_v10031953mg
TCC: 
108661886 108663133 18507240 18587033 18589881 18589884 18592353 18599823 18599828 18601594 18605869 18605934
GRA: 
105763982 105765366 105765367 105765368 105765408 105767646 105777756 105778083 105778084 105782479 105786164 105791250 105792628 105792629 105793470 105799382
GHI: 
107889315 107889317 107891421 107893152 107895385 107895907 107909353 107915194 107915880 107922183 107923436 107929578 107929579 107929580 107936289 107936296 107937281 107937285 107939017 107940407 107940414 107940417 107947186 107948794
EGR: 
104415145 104415146 104416154 104416156 104416158 104416159 104417513 104420045 104424243 104424567 104429247 104429248 104430455 104430810 104430849 104437195 104437201 104437219 104439341 104444139 104445600 104445601 104447137 104449485 104449526 104449528 104450510 104452413 104452416 104455705 104455715 104456234
GMX: 
100777636 100779492 100780100 100788873 100789402 100793053 100803633 106794104
PVU: 
PHAVU_003G006000g PHAVU_003G006100g PHAVU_009G044400g PHAVU_009G2586001 PHAVU_009G258700g PHAVU_009G258800g PHAVU_009G258900g PHAVU_009G259000g PHAVU_009G259100g PHAVU_009G259200g PHAVU_009G259300g PHAVU_009G259500g PHAVU_010G120200g PHAVU_L008600g
VRA: 
106753579 106760166 106760167 106760169 106764425 106766344 106778175
VAR: 
108322235 108322321 108322322 108331569 108332176 108335252 108337604 108346436 108347163
CCAJ: 
109787879 109787883 109789130 109789134 109792349 109792579 109792971 109793411 109793604 109794407 109797150 109797532 109806421 109817813 109817907
MTR: 
MTR_0591s0010 MTR_1g036460 MTR_1g036490 MTR_1g036510 MTR_1g050220 MTR_3g092900 MTR_5g098170 MTR_6g078850 MTR_7g118300 MTR_7g118320 MTR_8g024160 MTR_8g068570 MTR_8g068600 MTR_8g068690 MTR_8g068730 MTR_8g068740 MTR_8g068750 MTR_8g068870
CAM: 
101489645 101492092 101499314 101499972 101500319 101512074 101512403 101513904 101514542 101514683
ADU: 
107458024 107458050 107458053 107458054 107470102 107471785 107471786 107471788 107471789 107471790 107473073 107473077 107479743
AIP: 
107606820 107606821 107609676 107621172 107622469 107622470 107622471 107622472 107622473 107622793 107624476 107626705 107643318
LJA: 
Lj0g3v0105429.1(Lj0g3v0105429.1) Lj0g3v0124669.1(Lj0g3v0124669.1) Lj0g3v0273599.1(Lj0g3v0273599.1) Lj0g3v0306659.1(Lj0g3v0306659.1) Lj0g3v0346019.1(Lj0g3v0346019.1) Lj0g3v0354359.1(Lj0g3v0354359.1) Lj0g3v0364049.1(Lj0g3v0364049.1) Lj1g3v1079700.1(Lj1g3v1079700.1) Lj1g3v5060810.1(Lj1g3v5060810.1) Lj1g3v5060810.2(Lj1g3v5060810.2) Lj2g3v3339490.1(Lj2g3v3339490.1)
LANG: 
109328338 109329832 109329833 109338233 109343467 109345737 109345738 109355876 109359349 109359350
FVE: 
101292538 101294295 101296734 101308514
PPER: 
18776084 18784868 18786300 18786738 18786962 18787303 18790301
PMUM: 
103319810 103322531 103333559 103342357 103342358 103342359(OMT1) 103342360 103343871
MDM: 
103405809 103406240 103406241 103406249 103410332 103410396 103411915 103416301 103416926 103419371 103420798 103420847 103421923(OMT2) 103422036 103426402 103426499 103426529(omt1) 103426534 103428516 103428558 103429450 103429452 103431087 103431107 103433538 103439452 103439955 103439956 103439958 103443723(omt2) 103444096 103444340(OMT6) 103445678 108172651
PXB: 
103927980 103927981 103927983 103935025 103935026 103943351 103943352 103943506 103951568 103951571 103951572 103951578 103951641 103956347
ZJU: 
107414981 107414982 107418646 107418647 107418657 107418658 107418659 107423770 107423771 107423773 107423786 107423795 107429106 107429761 107434023
CSV: 
101204109 101205290 101210788 101214675 101214916
CMO: 
103491014 103491140 103501180 103503246 107990280 107990972
RCU: 
8270912 8270961 8270962 8282965 8285506 8288877
JCU: 
105631282 105631656 105632993 105634486 105635097 105635102 105635946 105636072 105639044 105639046 105641383 105642764 105645484 105646425 105646969 110009243
POP: 
POPTR_0001s45530g(POPTRDRAFT_550470) POPTR_0002s07730g POPTR_0002s18120g POPTR_0002s18130g POPTR_0002s18150g(POPTRDRAFT_552360) POPTR_0002s18160g(POPTRDRAFT_799151) POPTR_0005s20630g POPTR_0011s15360g(POPTRDRAFT_806142) POPTR_0012s00670g(POPTRDRAFT_834247) POPTR_0014s10210g(POPTRDRAFT_774571) POPTR_0014s10220g(POPTRDRAFT_731466) POPTR_0015s00550g(POPTRDRAFT_824484) POPTR_0016s10450g POPTR_0019s11400g
VVI: 
100232862 100232921(COMT) 100242108 100253843 100255690 100260649 100260763 100260786 100265976 100265990 100854172
SLY: 
101247834 101251452 101258157 101261963(CTOMT1) 101262824
SPEN: 
107002798 107015050 107021224 107022387 107022691 107023557 107023901
SOT: 
102579211 102580081 102590869 102598963 102599285 102599938 102601059 102601955 107058365
INI: 
109150685 109165820 109165828 109169365 109169372 109169378 109169387 109194027
SIND: 
105155388 105155389 105155459 105155461 105156074 105160270 105166789 105166790 105166791 105166792 105166793 105171204 105176053
BVG: 
104887972 104888149 104888150 104888557 104897755 104901566 104901641 104901795 104901881 104901967 104902057 104902142 104902234 104907961 104908865
NNU: 
104585771 104590656 104590659 104596816 104600131 104601399 104604834
DOSA: 
Os04t0175900-01(Os04g0175900) Os12t0199500-00(Os12g0199500) Os12t0202700-00(Os12g0202700) Os12t0240900-00(Os12g0240900)
OBR: 
102717362 102719765
BDI: 
100833782 100838174 100842290
ATS: 
F775_06936 F775_07800 F775_07801 F775_10047 F775_14227 F775_17739 F775_18115 F775_20925 F775_26153 F775_26154 F775_31276 F775_32449
ZMA: 
100125646(comt) 103640406
SITA: 
101754689 101761321 101765311 101772386
PDA: 
103696092 103706414 103716997
EGU: 
105037617 105042923 105054950 105054951 105054993 105054994
MUS: 
103971889 103971898 103971905 103971914 103971925 103971934 103971944 103971953 103971962 103972218 103972714 103973475 103973830 103973864 103973874 103973932 103974217 103974740 103974741 103974791 103974925 103975177 103978658 103980348 103982815 103998763 103998764 103998765 103999438 104000428
ATR: 
18424568
SMO: 
SELMODRAFT_112597 SELMODRAFT_124122 SELMODRAFT_124205 SELMODRAFT_134942 SELMODRAFT_134972 SELMODRAFT_227279 SELMODRAFT_227505 SELMODRAFT_3189 SELMODRAFT_3192 SELMODRAFT_450945(COMT1-2) SELMODRAFT_76630 SELMODRAFT_78541 SELMODRAFT_83100 SELMODRAFT_85724 SELMODRAFT_85878 SELMODRAFT_94918 SELMODRAFT_96831 SELMODRAFT_97635
PPP: 
PHYPADRAFT_175146 PHYPADRAFT_182345
 » show all
Taxonomy
Reference
1  [PMID:4472044]
  Authors
Ebel J, Schaller-Hekeler B, Knobloch KH, Wellman E, Grisebach H, Hahlbrock K.
  Title
Coordinated changes in enzyme activities of phenylpropanoid metabolism during the growth of soybean cell suspension cultures.
  Journal
Biochim. Biophys. Acta. 362 (1974) 417-24.
Reference
2  [PMID:241400]
  Authors
Poulton JE, Butt VS.
  Title
Purification and properties of S-adenosyl-L-methionine: caffeic acid O-methyltransferase from leaves of spinach beet (Beta vulgaris L).
  Journal
Biochim. Biophys. Acta. 403 (1975) 301-14.
Reference
3
  Authors
Shimada, M., Kuroda, H. and Higuchi, T.
  Title
Evidence for the formation of methoxyl groups of ferulic and sinapic acid in Bambusa by the same O-methyltransferase.
  Journal
Phytochemistry 12 (1973) 2873-2875.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
50936-45-3
LinkDB All DBs

KEGG   REACTION: R03366Help
Entry
R03366                      Reaction                               

Name
S-Adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase
Definition
S-Adenosyl-L-methionine + Caffeate <=> S-Adenosyl-L-homocysteine + Ferulate
Equation
Reaction class
C00019_C00021
C01197_C01494
Enzyme
Pathway
Phenylpropanoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K13066  
caffeic acid 3-O-methyltransferase [EC:2.1.1.68]
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