KEGG ORTHOLOGY: K13995

ORTHOLOGY: K13995

Entry

K13995 KO

Name

nicF

Definition

maleamate amidohydrolase [EC:3.5.1.107]

Pathway

ko00760

Nicotinate and nicotinamide metabolism

Module

M00622

Nicotinate degradation, nicotinate => fumarate

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    K13995  nicF; maleamate amidohydrolase
KEGG modules [BR:ko00002]
Pathway module
  Nucleotide and amino acid metabolism
   Cofactor and vitamin biosynthesis
    M00622  Nicotinate degradation, nicotinate => fumarate
     K13995  nicF; maleamate amidohydrolase
Enzymes [BR:ko01000]
3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.107  maleamate amidohydrolase
     K13995  nicF; maleamate amidohydrolase

Other DBs

RN:

R03540

COG:

COG1335

Genes

SPE:	Spro_2308
SRR:	SerAS9_2265
SRL:	SOD_c21380(nicF)
SRY:	M621_11715
SPLY:	Q5A_011850(nicF)
SRS:	SerAS12_2265
SRA:	SerAS13_2266
SMW:	SMWW4_v1c23220
SMAR:	SM39_1767
SMAC:	SMDB11_1580
SLQ:	M495_11485
SERF:	L085_17135
PAO:	Pat9b_5179
TCI:	A7K98_12075
SNJ:	A7E77_04550
PPU:	PP_3941(nicF)
PPF:	Pput_1896
PPG:	PputGB1_3576
PPW:	PputW619_2143
PPT:	PPS_4057
PPB:	PPUBIRD1_1867
PPI:	YSA_08973
PPX:	T1E_5126
PPUT:	L483_21695
PPUN:	PP4_17810
PFS:	PFLU_2796
PFW:	PF1751_v1c24670
PFB:	VO64_0123
PFF:	PFLUOLIPICF724395
PFX:	A7318_11845
PAZO:	AYR47_21600
PSK:	U771_14840
PFZ:	AV641_08710
PANR:	A7J50_2713
HAM:	HALO0540
HCO:	LOKO_02498(nicF_1)
ADI:	B5T_02293
MARS:	A8C75_16315
RPJ:	N234_04335 N234_24895
REU:	Reut_A2511 Reut_B3789
REH:	H16_A0926(h16_A0926) H16_B0814(h16_B0814)
CNC:	CNE_1c08760 CNE_2c07620
CTI:	RALTA_A0871
CBW:	RR42_s0172 RR42_s1173
CGD:	CR3_3006(nicF)
CCUP:	BKK81_07375
BCN:	Bcen_4328
BCH:	Bcen2424_4038
BCM:	Bcenmc03_3487
BCJ:	BCAM1141
BCEN:	DM39_3880
BCEO:	I35_4988
BMU:	Bmul_4551
BMK:	DM80_3721
BMUL:	NP80_4068
BCED:	DM42_3949
BCON:	NL30_06925
BSEM:	WJ12_25605
BPSL:	WS57_08420
BMEC:	WJ16_24235
BSTG:	WT74_20820
BGP:	BGL_1c11590
BGD:	bgla_1g12660
BGO:	BM43_2598
BYI:	BYI23_C007830 BYI23_D006270 BYI23_D011210
BUO:	BRPE64_CCDS01820 BRPE64_DCDS05950 BRPE64_DCDS11000
BUE:	BRPE67_CCDS03400 BRPE67_DCDS08090 BRPE67_DCDS13340
BPLA:	bpln_1g11110
BXE:	Bxe_C0217
BXB:	DR64_8214
BFN:	OI25_6798
BCAI:	K788_0007382
PSPU:	NA29_11635 NA29_13060
PVE:	UC34_12635
POX:	MB84_21145
PNR:	AT302_20400
BPE:	BP0582 BP1958
BPC:	BPTD_0591 BPTD_1930
BPER:	BN118_0956 BN118_3485
BPET:	B1917_3472
BPEU:	Q425_15040 Q425_35670
BPA:	BPP0272 BPP2331
BPAR:	BN117_0270 BN117_1485
BBR:	BB0275 BB1782
BBM:	BN115_0260 BN115_1684
BBH:	BN112_1733 BN112_3142
BBX:	BBS798_0270 BBS798_1683
BAV:	BAV1528 BAV2741
BBRO:	BAU06_12300 BAU06_25040
BFZ:	BAU07_14185 BAU07_25075
AXY:	AXYL_02467
AXO:	NH44784_051921
AXN:	AX27061_3328
AXS:	LH59_15730
AXX:	ERS451415_03308
ADT:	APT56_16405
AIS:	BUW96_02615 BUW96_28745
AKA:	TKWG_00620 TKWG_01110 TKWG_19785
AMIM:	MIM_c02060 MIM_c31070
AFA:	UZ73_09865 UZ73_10780 UZ73_14570 UZ73_14770
PHN:	PAEH1_09745
AAV:	Aave_3931
AAA:	Acav_3828
ACK:	C380_17110
DAC:	Daci_1849
DEL:	DelCs14_4789
DTS:	BI380_15405
DHK:	BO996_08755
VAP:	Vapar_4294
CTES:	O987_23200
HSE:	Hsero_1326(entB)
HSZ:	ACP92_06635
MLN:	A9174_33970
HOE:	IMCC20628_03532
AAK:	AA2016_6585
ATA:	AWN88_01315
RLG:	Rleg_6045
RTR:	RTCIAT899_PC08585
SHZ:	shn_30280
BOP:	AXW83_21105
BOS:	BSY19_2427
BVV:	BHK69_19725
HMC:	HYPMC_0202
PHL:	KKY_3789
RHZ:	RHPLAN_30740
PSIN:	CAK95_12380
PYE:	A6J80_00025 A6J80_23195
KVL:	KVU_1393
OAR:	OA238_c08180
CID:	P73_3891
CON:	TQ29_12575 TQ29_12805
PPHR:	APZ00_25435
YAN:	AYJ57_10105
TPRO:	Ga0080559_TMP3661
PABY:	Ga0080574_TMP30
LVS:	LOKVESSMR4R_02439(nicF) LOKVESSMR4R_03231(nicF)
NPP:	PP1Y_AT10712
NRE:	BES08_19555 BES08_22305
SPHI:	TS85_14910
SMY:	BJP26_14905
SPHG:	AZE99_12515 AZE99_14810
BLAS:	BSY18_2243
ELQ:	Ga0102493_11587
PORL:	BG023_112530
GOY:	GLS_c14240
GAL:	A0U94_10310
GXL:	H845_1041
KEU:	S101446_01673(nicF)
APT:	APA01_23750
APW:	APA42C_23750
APF:	APA03_23750
APU:	APA07_23750
APG:	APA12_23750
APQ:	APA22_23750
APX:	APA26_23750
APZ:	APA32_23750
APK:	APA386B_1209
ASV:	WG31_11900
ALI:	AZOLI_p20438
ABS:	AZOBR_p230065 AZOBR_p230071 AZOBR_p480012
ABQ:	ABAZ39_26740 ABAZ39_26770 ABAZ39_30175
ABF:	AMK58_24295 AMK58_24325 AMK58_25900
ATI:	AL072_18540 AL072_18570 AL072_30660
TAP:	GZ22_02460
PNP:	IJ22_15990
MSG:	MSMEI_4027
MSB:	LJ00_20465
MSN:	LI99_20470
MSH:	LI98_20475
ROA:	Pd630_LPD07323
SVL:	Strvi_4761
SRC:	M271_44550
SALU:	DC74_1458
SALL:	SAZ_07815
STRE:	GZL_07757
SNR:	SNOUR_35440
MPAL:	BO218_11365
AAQ:	AOC05_01020
BSD:	BLASA_3399
MMAR:	MODMU_4051
AMQ:	AMETH_3943
PDX:	Psed_4797
PSEA:	WY02_22140
PSEE:	FRP1_20550
PSEH:	XF36_05355
PSEQ:	AD006_27970
PECQ:	AD017_07565
PHH:	AFB00_17890
AMS:	AMIS_57510
AFS:	AFR_17595
AYM:	YM304_39650

» show all

Reference

PMID:18678916

Authors

Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E

Title

Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440.

Journal

Proc Natl Acad Sci U S A 105:11329-34 (2008)
DOI:10.1073/pnas.0802273105

Sequence

[ppu:PP_3941]

LinkDB

ENZYME: 3.5.1.107

Entry

EC 3.5.1.107 Enzyme

Name

maleamate amidohydrolase;
NicF

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides

Sysname

maleamate amidohydrolase

Reaction(IUBMB)

maleamate + H2O = maleate + NH3 [RN:R03540]

Reaction(KEGG)

R03540

Substrate

maleamate [CPD:C01596];
H2O [CPD:C00001]

Product

maleate [CPD:C01384];
NH3 [CPD:C00014]

Comment

The reaction is involved in the aerobic catabolism of nicotinic acid.

History

EC 3.5.1.107 created 2010

Pathway

ec00760	Nicotinate and nicotinamide metabolism
ec01120	Microbial metabolism in diverse environments

Orthology

K13995

maleamate amidohydrolase

Genes

SPE:	Spro_2308
SRR:	SerAS9_2265
SRL:	SOD_c21380(nicF)
SRY:	M621_11715
SPLY:	Q5A_011850(nicF)
SRS:	SerAS12_2265
SRA:	SerAS13_2266
SMW:	SMWW4_v1c23220
SMAR:	SM39_1767
SMAC:	SMDB11_1580
SLQ:	M495_11485
SERF:	L085_17135
PAO:	Pat9b_5179
TCI:	A7K98_12075
SNJ:	A7E77_04550
PPU:	PP_3941(nicF)
PPF:	Pput_1896
PPG:	PputGB1_3576
PPW:	PputW619_2143
PPT:	PPS_4057
PPB:	PPUBIRD1_1867
PPI:	YSA_08973
PPX:	T1E_5126
PPUT:	L483_21695
PPUN:	PP4_17810
PFS:	PFLU_2796
PFW:	PF1751_v1c24670
PFB:	VO64_0123
PFF:	PFLUOLIPICF724395
PFX:	A7318_11845
PAZO:	AYR47_21600
PSK:	U771_14840
PFZ:	AV641_08710
PANR:	A7J50_2713
HAM:	HALO0540
HCO:	LOKO_02498(nicF_1)
ADI:	B5T_02293
MARS:	A8C75_16315
RPJ:	N234_04335 N234_24895
REU:	Reut_A2511 Reut_B3789
REH:	H16_A0926(h16_A0926) H16_B0814(h16_B0814)
CNC:	CNE_1c08760 CNE_2c07620
CTI:	RALTA_A0871
CBW:	RR42_s0172 RR42_s1173
CGD:	CR3_3006(nicF)
CCUP:	BKK81_07375
BCN:	Bcen_4328
BCH:	Bcen2424_4038
BCM:	Bcenmc03_3487
BCJ:	BCAM1141
BCEN:	DM39_3880
BCEO:	I35_4988
BMU:	Bmul_4551
BMK:	DM80_3721
BMUL:	NP80_4068
BCED:	DM42_3949
BCON:	NL30_06925
BSEM:	WJ12_25605
BPSL:	WS57_08420
BMEC:	WJ16_24235
BSTG:	WT74_20820
BGP:	BGL_1c11590
BGD:	bgla_1g12660
BGO:	BM43_2598
BYI:	BYI23_C007830 BYI23_D006270 BYI23_D011210
BUO:	BRPE64_CCDS01820 BRPE64_DCDS05950 BRPE64_DCDS11000
BUE:	BRPE67_CCDS03400 BRPE67_DCDS08090 BRPE67_DCDS13340
BPLA:	bpln_1g11110
BXE:	Bxe_C0217
BXB:	DR64_8214
BFN:	OI25_6798
BCAI:	K788_0007382
PSPU:	NA29_11635 NA29_13060
PVE:	UC34_12635
POX:	MB84_21145
PNR:	AT302_20400
BPE:	BP0582 BP1958
BPC:	BPTD_0591 BPTD_1930
BPER:	BN118_0956 BN118_3485
BPET:	B1917_3472
BPEU:	Q425_15040 Q425_35670
BPA:	BPP0272 BPP2331
BPAR:	BN117_0270 BN117_1485
BBR:	BB0275 BB1782
BBM:	BN115_0260 BN115_1684
BBH:	BN112_1733 BN112_3142
BBX:	BBS798_0270 BBS798_1683
BAV:	BAV1528 BAV2741
BBRO:	BAU06_12300 BAU06_25040
BFZ:	BAU07_14185 BAU07_25075
AXY:	AXYL_02467
AXO:	NH44784_051921
AXN:	AX27061_3328
AXS:	LH59_15730
AXX:	ERS451415_03308
ADT:	APT56_16405
AIS:	BUW96_02615 BUW96_28745
AKA:	TKWG_00620 TKWG_01110 TKWG_19785
AMIM:	MIM_c02060 MIM_c31070
AFA:	UZ73_09865 UZ73_10780 UZ73_14570 UZ73_14770
PHN:	PAEH1_09745
AAV:	Aave_3931
AAA:	Acav_3828
ACK:	C380_17110
DAC:	Daci_1849
DEL:	DelCs14_4789
DTS:	BI380_15405
DHK:	BO996_08755
VAP:	Vapar_4294
CTES:	O987_23200
HSE:	Hsero_1326(entB)
HSZ:	ACP92_06635
MLN:	A9174_33970
HOE:	IMCC20628_03532
AAK:	AA2016_6585
ATA:	AWN88_01315
RLG:	Rleg_6045
RTR:	RTCIAT899_PC08585
SHZ:	shn_30280
BOP:	AXW83_21105
BOS:	BSY19_2427
BVV:	BHK69_19725
HMC:	HYPMC_0202
PHL:	KKY_3789
RHZ:	RHPLAN_30740
PSIN:	CAK95_12380
PYE:	A6J80_00025 A6J80_23195
KVL:	KVU_1393
OAR:	OA238_c08180
CID:	P73_3891
CON:	TQ29_12575 TQ29_12805
PPHR:	APZ00_25435
YAN:	AYJ57_10105
TPRO:	Ga0080559_TMP3661
PABY:	Ga0080574_TMP30
LVS:	LOKVESSMR4R_02439(nicF) LOKVESSMR4R_03231(nicF)
NPP:	PP1Y_AT10712
NRE:	BES08_19555 BES08_22305
SPHI:	TS85_14910
SMY:	BJP26_14905
SPHG:	AZE99_12515 AZE99_14810
BLAS:	BSY18_2243
ELQ:	Ga0102493_11587
PORL:	BG023_112530
GOY:	GLS_c14240
GAL:	A0U94_10310
GXL:	H845_1041
KEU:	S101446_01673(nicF)
APT:	APA01_23750
APW:	APA42C_23750
APF:	APA03_23750
APU:	APA07_23750
APG:	APA12_23750
APQ:	APA22_23750
APX:	APA26_23750
APZ:	APA32_23750
APK:	APA386B_1209
ASV:	WG31_11900
ALI:	AZOLI_p20438
ABS:	AZOBR_p230065 AZOBR_p230071 AZOBR_p480012
ABQ:	ABAZ39_26740 ABAZ39_26770 ABAZ39_30175
ABF:	AMK58_24295 AMK58_24325 AMK58_25900
ATI:	AL072_18540 AL072_18570 AL072_30660
TAP:	GZ22_02460
PNP:	IJ22_15990
MSG:	MSMEI_4027
MSB:	LJ00_20465
MSN:	LI99_20470
MSH:	LI98_20475
ROA:	Pd630_LPD07323
SVL:	Strvi_4761
SRC:	M271_44550
SALU:	DC74_1458
SALL:	SAZ_07815
STRE:	GZL_07757
SNR:	SNOUR_35440
MPAL:	BO218_11365
AAQ:	AOC05_01020
BSD:	BLASA_3399
MMAR:	MODMU_4051
AMQ:	AMETH_3943
PDX:	Psed_4797
PSEA:	WY02_22140
PSEE:	FRP1_20550
PSEH:	XF36_05355
PSEQ:	AD006_27970
PECQ:	AD017_07565
PHH:	AFB00_17890
AMS:	AMIS_57510
AFS:	AFR_17595
AYM:	YM304_39650