KEGG ORTHOLOGY: K14418

ORTHOLOGY: K14418

Entry

K14418            Tight     KO

Symbol

fcbB

Name

4-chlorobenzoyl-CoA dehalogenase [EC:3.8.1.7]

Pathway

map00364

Fluorobenzoate degradation

map01120

Microbial metabolism in diverse environments

Reaction

R04101

4-chlorobenzoyl CoA chlorohydrolase

R08118

4-fluorobenzoyl CoA fluorohydrolase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00364 Fluorobenzoate degradation
    K14418  fcbB; 4-chlorobenzoyl-CoA dehalogenase
Enzymes [BR:ko01000]
3. Hydrolases
  3.8  Acting on halide bonds
   3.8.1  In carbon-halide compounds
    3.8.1.7  4-chlorobenzoyl-CoA dehalogenase
     K14418  fcbB; 4-chlorobenzoyl-CoA dehalogenase

Other DBs

GO:

0018787

Genes

AG:	ABQ44578(fcbB)

Reference

PMID:18355280

Authors

Chae JC, Song B, Zylstra GJ

Title

Identification of genes coding for hydrolytic dehalogenation in the metagenome derived from a denitrifying 4-chlorobenzoate degrading consortium.

Journal

FEMS Microbiol Lett 281:203-9 (2008)
DOI:10.1111/j.1574-6968.2008.01106.x

Reference

PMID:7765837

Authors

Dunaway-Mariano D, Babbitt PC

Title

On the origins and functions of the enzymes of the 4-chlorobenzoate to 4-hydroxybenzoate converting pathway.

Journal

Biodegradation 5:259-76 (1994)
DOI:10.1007/BF00696464

Reference

PMID:1610806

Authors

Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D

Title

Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3.

Journal

Biochemistry 31:5605-10 (1992)
DOI:10.1021/bi00139a025

Sequence

[ag:ABQ44578]

LinkDB

ENZYME: 3.8.1.7

Entry

EC 3.8.1.7                  Enzyme

Name

4-chlorobenzoyl-CoA dehalogenase

Class

Hydrolases;
Acting on halide bonds;
In carbon-halide compounds

Sysname

4-chlorobenzoyl CoA chlorohydrolase

Reaction(IUBMB)

4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride [RN:R04101]

Reaction(KEGG)

R04101;
(other) R08118

Substrate

4-chlorobenzoyl-CoA [CPD:C06387];
H2O [CPD:C00001]

Product

4-hydroxybenzoyl CoA;
chloride [CPD:C00698]

Comment

Specific for dehalogenation at the 4-position. Can dehalogenate substrates bearing fluorine, chlorine, bromine and iodine in the 4-position. This enzyme is part of the bacterial 2,4-dichlorobenzoate degradation pathway.

History

EC 3.8.1.7 created 1999

Pathway

ec00364

Fluorobenzoate degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K14418

4-chlorobenzoyl-CoA dehalogenase

Reference

1 [PMID:1610806]

Authors

Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D

Title

Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3.

Journal

Biochemistry 31:5605-10 (1992)
DOI:10.1021/bi00139a025

Sequence

[ag:ABQ44578]

Reference

2 [PMID:7918379]

Authors

Crooks GP, Copley SD

Title

Purification and characterization of 4-chlorobenzoyl CoA dehalogenase from Arthrobacter sp. strain 4-CB1.

Journal

Biochemistry 33:11645-9 (1994)
DOI:10.1021/bi00204a028

Other DBs

ExplorEnz - The Enzyme Database:

3.8.1.7

IUBMB Enzyme Nomenclature:

3.8.1.7

ExPASy - ENZYME nomenclature database:

3.8.1.7

UM-BBD (Biocatalysis/Biodegradation Database):

3.8.1.7

BRENDA, the Enzyme Database:

3.8.1.7

CAS:	141583-18-8

LinkDB

REACTION: R08118

Entry

R08118                      Reaction

Name

4-fluorobenzoyl CoA fluorohydrolase

Definition

4-Fluorobenzoyl-CoA + H2O <=> 4-Hydroxybenzoyl-CoA + Hydrofluoric acid

Equation

C02802 + C00001 <=> C02949 + C16487

Reaction class

RC00492

C02802_C02949

Enzyme

3.8.1.7

Pathway

rn00364

Fluorobenzoate degradation

rn01120

Microbial metabolism in diverse environments

Brite

Enzymatic reactions [BR:br08201]
3. Hydrolase reactions
  3.8  Acting on halide bonds
   3.8.1  In carbon-halide compounds
    3.8.1.7
     R08118  4-Fluorobenzoyl-CoA + H2O <=> 4-Hydroxybenzoyl-CoA + Hydrofluoric acid

Orthology

K14418

4-chlorobenzoyl-CoA dehalogenase [EC:3.8.1.7]

LinkDB

DBGET integrated database retrieval system