KEGG   ORTHOLOGY: K14466Help
Entry
K14466                      KO                                     

Name
K14466
Definition
4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40]
Pathway
Carbon fixation pathways in prokaryotes
Carbon metabolism
Module
M00375  
Hydroxypropionate-hydroxybutylate cycle
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01200 Carbon metabolism
    K14466  K14466; 4-hydroxybutyrate---CoA ligase (AMP-forming)
  Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K14466  K14466; 4-hydroxybutyrate---CoA ligase (AMP-forming)
KEGG modules [BR:ko00002]
 Pathway module
  Energy metabolism
   Carbon fixation
    M00375  Hydroxypropionate-hydroxybutylate cycle
     K14466  K14466; 4-hydroxybutyrate---CoA ligase (AMP-forming)
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.40  4-hydroxybutyrate---CoA ligase
     K14466  K14466; 4-hydroxybutyrate---CoA ligase (AMP-forming)
BRITE hierarchy
Other DBs
RN: 
COG: 
Genes
AFU: 
AFG: 
APO: 
GAC: 
SACN: 
SACR: 
SACS: 
MSE: 
MCN: 
TaxonomyKoalaUniProt
Reference
  Authors
Hawkins AS, Han Y, Bennett RK, Adams MW, Kelly RM
  Title
Role of 4-hydroxybutyrate-CoA synthetase in the CO2 fixation cycle in thermoacidophilic archaea.
  Journal
J Biol Chem 288:4012-22 (2013)
DOI:10.1074/jbc.M112.413195
  Sequence
[mse:Msed_0406]
LinkDB All DBs

KEGG   ORTHOLOGY: K14467Help
Entry
K14467                      KO                                     

Name
4hbl
Definition
4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40]
Pathway
Carbon fixation pathways in prokaryotes
Carbon metabolism
Module
M00374  
Dicarboxylate-hydroxybutyrate cycle
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01200 Carbon metabolism
    K14467  4hbl; 4-hydroxybutyrate---CoA ligase (AMP-forming)
  Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K14467  4hbl; 4-hydroxybutyrate---CoA ligase (AMP-forming)
KEGG modules [BR:ko00002]
 Pathway module
  Energy metabolism
   Carbon fixation
    M00374  Dicarboxylate-hydroxybutyrate cycle
     K14467  4hbl; 4-hydroxybutyrate---CoA ligase (AMP-forming)
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.40  4-hydroxybutyrate---CoA ligase
     K14467  4hbl; 4-hydroxybutyrate---CoA ligase (AMP-forming)
BRITE hierarchy
Other DBs
RN: 
COG: 
Genes
AHO: 
PAI: 
PIS: 
PCL: 
PYR: 
POG: 
TNE: 
TUZ: 
TTN: 
TTX_1100(acsA)
TaxonomyKoalaUniProt
Reference
  Authors
Ramos-Vera WH, Weiss M, Strittmatter E, Kockelkorn D, Fuchs G
  Title
Identification of missing genes and enzymes for autotrophic carbon fixation in crenarchaeota.
  Journal
J Bacteriol 193:1201-11 (2011)
DOI:10.1128/JB.01156-10
  Sequence
[tne:Tneu_0420]
LinkDB All DBs

KEGG   ORTHOLOGY: K18861Help
Entry
K18861                      KO                                     

Name
K18861
Definition
4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40]
Pathway
Carbon fixation pathways in prokaryotes
Carbon metabolism
Module
M00374  
Dicarboxylate-hydroxybutyrate cycle
M00375  
Hydroxypropionate-hydroxybutylate cycle
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01200 Carbon metabolism
    K18861  K18861; 4-hydroxybutyrate---CoA ligase (AMP-forming)
  Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K18861  K18861; 4-hydroxybutyrate---CoA ligase (AMP-forming)
KEGG modules [BR:ko00002]
 Pathway module
  Energy metabolism
   Carbon fixation
    M00375  Hydroxypropionate-hydroxybutylate cycle
     K18861  K18861; 4-hydroxybutyrate---CoA ligase (AMP-forming)
    M00374  Dicarboxylate-hydroxybutyrate cycle
     K18861  K18861; 4-hydroxybutyrate---CoA ligase (AMP-forming)
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.40  4-hydroxybutyrate---CoA ligase
     K18861  K18861; 4-hydroxybutyrate---CoA ligase (AMP-forming)
BRITE hierarchy
Other DBs
RN: 
COG: 
Genes
IHO: 
PFM: 
SSO: 
SSO1595(alkK-1)
SOL: 
SSOA: 
SSOL: 
SSOF: 
STO: 
SAI: 
SACN: 
SACR: 
SacRon12I_10700
SACS: 
SUSAZ_09795
SIS: 
LS215_1135
SIA: 
M1425_0518
SIM: 
M1627_0847
SID: 
M164_0543
SIY: 
YG5714_0492
SII: 
LD85_0554
SIH: 
SiH_0833
SIR: 
SiRe_0517
SIC: 
SiL_0542
SULA: 
BFU36_11215
MSE: 
Msed_1422
MCN: 
Mcup_0813
AHO: 
Ahos_2275
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Huber H, Gallenberger M, Jahn U, Eylert E, Berg IA, Kockelkorn D, Eisenreich W, Fuchs G
  Title
A dicarboxylate/4-hydroxybutyrate autotrophic carbon assimilation cycle in the hyperthermophilic Archaeum Ignicoccus hospitalis.
  Journal
Proc Natl Acad Sci U S A 105:7851-6 (2008)
DOI:10.1073/pnas.0801043105
  Sequence
[iho:Igni_0475]
LinkDB All DBs

KEGG   ORTHOLOGY: K18593Help
Entry
K18593                      KO                                     

Name
K18593
Definition
4-hydroxybutyryl-CoA synthetase (ADP-forming) [EC:6.2.1.-]
Pathway
Carbon fixation pathways in prokaryotes
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K18593  K18593; 4-hydroxybutyryl-CoA synthetase (ADP-forming)
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.-  
     K18593  K18593; 4-hydroxybutyryl-CoA synthetase (ADP-forming)
BRITE hierarchy
Other DBs
RN: 
COG: 
Genes
NMR: 
NIR: 
NID: 
NIN: 
CSY: 
NGA: 
NVN: 
NEV: 
TAA: 
NMY3_00758(sucD_1)
NBV: 
TAH: 
SU86_007640
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Konneke M, Schubert DM, Brown PC, Hugler M, Standfest S, Schwander T, Schada von Borzyskowski L, Erb TJ, Stahl DA, Berg IA
  Title
Ammonia-oxidizing archaea use the most energy-efficient aerobic pathway for CO2 fixation.
  Journal
Proc Natl Acad Sci U S A 111:8239-44 (2014)
DOI:10.1073/pnas.1402028111
  Sequence
[nmr:Nmar_0206]
LinkDB All DBs

KEGG   ENZYME: 6.2.1.40Help
Entry
EC 6.2.1.40                 Enzyme                                 

Name
4-hydroxybutyrate---CoA ligase;
4-hydroxybutyrate-CoA synthetase;
4-hydroxybutyrate:CoA ligase (AMP-forming)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
4-hydroxybutanoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 4-hydroxybutanoate + CoA = AMP + diphosphate + 4-hydroxybutanoyl-CoA [RN:R09279]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
4-hydroxybutanoate [CPD:C00989];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
4-hydroxybutanoyl-CoA [CPD:C11062]
Comment
Isolated from the archaeon Metallosphaera sedula. Involved in the 3-hydroxypropanoate/4-hydroxybutanoate cycle.
History
EC 6.2.1.40 created 2014
Pathway
Carbon fixation pathways in prokaryotes
Microbial metabolism in diverse environments
Orthology
K14466  
4-hydroxybutyrate---CoA ligase (AMP-forming)
K14467  
4-hydroxybutyrate---CoA ligase (AMP-forming)
K18861  
4-hydroxybutyrate---CoA ligase (AMP-forming)
Genes
AFU: 
AFG: 
APO: 
GAC: 
IHO: 
PFM: 
SSO: 
SSO1595(alkK-1)
SOL: 
SSOA: 
SSOL: 
SSOF: 
SULC_2448
STO: 
STK_20950
SAI: 
Saci_2146
SACN: 
SacN8_05595 SacN8_10445
SACR: 
SacRon12I_05585 SacRon12I_10700
SACS: 
SUSAZ_05485 SUSAZ_09795
SIS: 
LS215_1135
SIA: 
M1425_0518
SIM: 
M1627_0847
SID: 
M164_0543
SIY: 
YG5714_0492
SII: 
LD85_0554
SIH: 
SiH_0833
SIR: 
SiRe_0517
SIC: 
SiL_0542
SULA: 
BFU36_11215
MSE: 
Msed_0406 Msed_1422
MCN: 
Mcup_0813 Mcup_1674
AHO: 
Ahos_0918 Ahos_2275
PAI: 
PAE2474
PIS: 
Pisl_0250
PCL: 
Pcal_1386
PYR: 
P186_0721 P186_1145
POG: 
Pogu_1296
TNE: 
Tneu_0420
TUZ: 
TUZN_0914
TTN: 
TTX_1100(acsA)
 » show all
Taxonomy
Reference
1  [PMID:21169482]
  Authors
Ramos-Vera WH, Weiss M, Strittmatter E, Kockelkorn D, Fuchs G
  Title
Identification of missing genes and enzymes for autotrophic carbon fixation in crenarchaeota.
  Journal
J. Bacteriol. 193 (2011) 1201-11.
  Sequence
[tne:Tneu_0420]
Reference
2  [PMID:23258541]
  Authors
Hawkins AS, Han Y, Bennett RK, Adams MW, Kelly RM
  Title
Role of 4-hydroxybutyrate-CoA synthetase in the CO2 fixation cycle in thermoacidophilic archaea.
  Journal
J. Biol. Chem. 288 (2013) 4012-22.
  Sequence
[mse:Msed_0406]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
LinkDB All DBs

KEGG   REACTION: R09279Help
Entry
R09279                      Reaction                               

Name
4-hydroxybutanoate:CoA ligase (AMP-forming)
Definition
4-Hydroxybutanoic acid + ATP + CoA <=> 4-Hydroxybutyryl-CoA + AMP + Diphosphate
Equation
Reaction class
C00010_C11062
C00989_C11062
Enzyme
Pathway
Carbon fixation pathways in prokaryotes
Microbial metabolism in diverse environments
Carbon metabolism
Module
M00374  
Dicarboxylate-hydroxybutyrate cycle
M00375  
Hydroxypropionate-hydroxybutylate cycle
Orthology
K14466  
4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40]
K14467  
4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40]
K18861  
4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40]
Other DBs
RHEA: 
LinkDB All DBs

KEGG   REACTION: R10758Help
Entry
R10758                      Reaction                               

Name
4-hydroxybutanoate:CoA ligase (ADP-forming)
Definition
4-Hydroxybutanoic acid + ATP + CoA <=> 4-Hydroxybutyryl-CoA + ADP + Orthophosphate
Equation
Comment
4-hydroxybutyryl-CoA synthetase (ADP-forming)
Reaction class
C00002_C00008
C00010_C11062
C00989_C11062
Enzyme
6.2.1.-
Pathway
Carbon fixation pathways in prokaryotes
Microbial metabolism in diverse environments
Orthology
K18593  
4-hydroxybutyryl-CoA synthetase (ADP-forming) [EC:6.2.1.-]
LinkDB All DBs

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