KEGG   ORTHOLOGY: K14469Help
Entry
K14469                      KO                                     

Name
K14469
Definition
acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase [EC:1.3.1.84 4.2.1.116 6.2.1.36]
Pathway
Carbon fixation pathways in prokaryotes
Carbon metabolism
Module
M00376  
3-Hydroxypropionate bi-cycle
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01200 Carbon metabolism
    K14469  K14469; acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase
  Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K14469  K14469; acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase
KEGG modules [BR:ko00002]
 Pathway module
  Energy metabolism
   Carbon fixation
    M00376  3-Hydroxypropionate bi-cycle
     K14469  K14469; acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.84  acrylyl-CoA reductase (NADPH)
     K14469  K14469; acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.116  3-hydroxypropionyl-CoA dehydratase
     K14469  K14469; acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.36  3-hydroxypropionyl-CoA synthase
     K14469  K14469; acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase
BRITE hierarchy
Other DBs
Genes
RRS: 
RCA: 
CAU: 
CAG: 
CHL: 
CTM: 
CTS: 
TaxonomyKoalaUniProt
Reference
  Authors
Zarzycki J, Brecht V, Muller M, Fuchs G
  Title
Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus.
  Journal
Proc Natl Acad Sci U S A 106:21317-22 (2009)
DOI:10.1073/pnas.0908356106
Reference
  Authors
Alber BE, Fuchs G
  Title
Propionyl-coenzyme A synthase from Chloroflexus aurantiacus, a key enzyme of the  3-hydroxypropionate cycle for autotrophic CO2 fixation.
  Journal
J Biol Chem 277:12137-43 (2002)
DOI:10.1074/jbc.M110802200
  Sequence
LinkDB All DBs

KEGG   ORTHOLOGY: K15018Help
Entry
K15018                      KO                                     

Name
K15018
Definition
3-hydroxypropionyl-coenzyme A synthetase [EC:6.2.1.36]
Pathway
Carbon fixation pathways in prokaryotes
Carbon metabolism
Module
M00375  
Hydroxypropionate-hydroxybutylate cycle
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01200 Carbon metabolism
    K15018  K15018; 3-hydroxypropionyl-coenzyme A synthetase
  Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K15018  K15018; 3-hydroxypropionyl-coenzyme A synthetase
KEGG modules [BR:ko00002]
 Pathway module
  Energy metabolism
   Carbon fixation
    M00375  Hydroxypropionate-hydroxybutylate cycle
     K15018  K15018; 3-hydroxypropionyl-coenzyme A synthetase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.36  3-hydroxypropionyl-CoA synthase
     K15018  K15018; 3-hydroxypropionyl-coenzyme A synthetase
BRITE hierarchy
Other DBs
RN: 
COG: 
GO: 
Genes
SSO: 
SSO3203(acsA-10)
SOL: 
SSOA: 
SSOL: 
SSOF: 
STO: 
SAI: 
SACN: 
SACR: 
SACS: 
SIS: 
LS215_2320
SIA: 
M1425_2157
SIM: 
M1627_2237
SID: 
M164_2161
SIY: 
YG5714_2284
SIN: 
YN1551_0632
SII: 
LD85_2424
SIH: 
SiH_2103
SIR: 
SiRe_2035
SIC: 
SiL_2010
SULA: 
BFU36_06065
MSE: 
Msed_1456
MCN: 
Mcup_0744
AHO: 
Ahos_2066
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Ramos-Vera WH, Weiss M, Strittmatter E, Kockelkorn D, Fuchs G
  Title
Identification of missing genes and enzymes for autotrophic carbon fixation in crenarchaeota.
  Journal
J Bacteriol 193:1201-11 (2011)
DOI:10.1128/JB.01156-10
LinkDB All DBs

KEGG   ORTHOLOGY: K18594Help
Entry
K18594                      KO                                     

Name
K18594
Definition
3-hydroxypropionyl-CoA synthetase (ADP-forming) [EC:6.2.1.-]
Pathway
Carbon fixation pathways in prokaryotes
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K18594  K18594; 3-hydroxypropionyl-CoA synthetase (ADP-forming)
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.-  
     K18594  K18594; 3-hydroxypropionyl-CoA synthetase (ADP-forming)
BRITE hierarchy
Other DBs
RN: 
COG: 
Genes
NMR: 
NIR: 
NID: 
NIN: 
NKR: 
CSY: 
NGA: 
NVN: 
NEV: 
NBV: 
TAH: 
SU86_009005
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Konneke M, Schubert DM, Brown PC, Hugler M, Standfest S, Schwander T, Schada von Borzyskowski L, Erb TJ, Stahl DA, Berg IA
  Title
Ammonia-oxidizing archaea use the most energy-efficient aerobic pathway for CO2 fixation.
  Journal
Proc Natl Acad Sci U S A 111:8239-44 (2014)
DOI:10.1073/pnas.1402028111
  Sequence
[nmr:Nmar_1309]
LinkDB All DBs

KEGG   ENZYME: 6.2.1.36Help
Entry
EC 6.2.1.36                 Enzyme                                 

Name
3-hydroxypropionyl-CoA synthase;
3-hydroxypropionyl-CoA synthetase (AMP-forming);
3-hydroxypropionate---CoA ligase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
hydroxypropanoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + AMP + diphosphate [RN:R09286]
Reaction(KEGG)
Substrate
3-hydroxypropanoate [CPD:C01013];
ATP [CPD:C00002];
CoA [CPD:C00010]
Product
3-hydroxypropanoyl-CoA [CPD:C05668];
AMP [CPD:C00020];
diphosphate [CPD:C00013]
Comment
Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1,2].The enzymes from Metallosphaera sedula and Sulfolobus tokodaii can also use propionate, acrylate, acetate, and butanoate as substrates [2], and are thus different from EC 6.2.1.17 (propionate---CoA ligase), which does not accept acetate or butanoate.
History
EC 6.2.1.36 created 2009
Pathway
Carbon fixation pathways in prokaryotes
Microbial metabolism in diverse environments
Orthology
K14469  
acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase
K15018  
3-hydroxypropionyl-coenzyme A synthetase
Genes
RRS: 
RCA: 
CAU: 
CAG: 
CHL: 
CTM: 
CTS: 
SSO: 
SSO3203(acsA-10)
SOL: 
SSOA: 
SSOL: 
SULB_0975
SSOF: 
SULC_0974
STO: 
STK_07830
SAI: 
Saci_1184
SACN: 
SacN8_05775
SACR: 
SacRon12I_05770
SACS: 
SUSAZ_05635
SIS: 
LS215_2320
SIA: 
M1425_2157
SIM: 
M1627_2237
SID: 
M164_2161
SIY: 
YG5714_2284
SIN: 
YN1551_0632
SII: 
LD85_2424
SIH: 
SiH_2103
SIR: 
SiRe_2035
SIC: 
SiL_2010
SULA: 
BFU36_06065
MSE: 
Msed_1456
MCN: 
Mcup_0744
AHO: 
Ahos_2066
 » show all
Taxonomy
Reference
1  [PMID:18079405]
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science. 318 (2007) 1782-6.
Reference
2  [PMID:18165310]
  Authors
Alber BE, Kung JW, Fuchs G
  Title
3-Hydroxypropionyl-coenzyme A synthetase from Metallosphaera sedula, an enzyme involved in autotrophic CO2 fixation.
  Journal
J. Bacteriol. 190 (2008) 1383-9.
  Sequence
[mse:Msed_1456][sto:STK_07830]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
LinkDB All DBs

KEGG   REACTION: R09286Help
Entry
R09286                      Reaction                               

Name
3-hydroxypropionate:CoA ligase (AMP-forming)
Definition
3-Hydroxypropionyl-CoA + Diphosphate + AMP <=> 3-Hydroxypropanoate + CoA + ATP
Equation
Comment
3-hydroxypropionyl-CoA synthetase
Reaction class
C00010_C05668
C01013_C05668
Enzyme
Pathway
Carbon fixation pathways in prokaryotes
Microbial metabolism in diverse environments
Carbon metabolism
Module
M00375  
Hydroxypropionate-hydroxybutylate cycle
M00376  
3-Hydroxypropionate bi-cycle
Orthology
K14469  
acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase [EC:1.3.1.84 4.2.1.116 6.2.1.36]
K15018  
3-hydroxypropionyl-coenzyme A synthetase [EC:6.2.1.36]
Other DBs
RHEA: 
LinkDB All DBs

KEGG   REACTION: R03157Help
Entry
R03157                      Reaction                               

Definition
3-Hydroxypropionyl-CoA + Orthophosphate + ADP <=> 3-Hydroxypropanoate + CoA + ATP
Equation
Comment
3-hydroxypropionyl-CoA synthetase (ADP-forming)
Reaction class
C00002_C00008
C00010_C05668
C01013_C05668
Enzyme
6.2.1.-
Pathway
Carbon fixation pathways in prokaryotes
Microbial metabolism in diverse environments
Orthology
K18594  
3-hydroxypropionyl-CoA synthetase (ADP-forming) [EC:6.2.1.-]
LinkDB All DBs

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