KEGG   ORTHOLOGY: K14519Help
Entry
K14519                      KO                                     

Name
aldH
Definition
NADP-dependent aldehyde dehydrogenase [EC:1.2.1.4]
Pathway
Caprolactam degradation
Degradation of aromatic compounds
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K14519  aldH; NADP-dependent aldehyde dehydrogenase
  Xenobiotics biodegradation and metabolism
   00930 Caprolactam degradation
    K14519  aldH; NADP-dependent aldehyde dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.4  aldehyde dehydrogenase (NADP+)
     K14519  aldH; NADP-dependent aldehyde dehydrogenase
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
POL: 
AAV: 
AAA: 
PDE: 
HBA: 
MGO: 
NBR: 
RHA: 
REB: 
ROP: 
ROA: 
Pd630_LPD07647
GPO: 
GPOL_c08310
SCO: 
SCO1871(SCI39.18c)
SMA: 
SAV_6389
SGR: 
SGR_1630 SGR_5625
SGB: 
WQO_07195
SCB: 
SCAB_70651
SSX: 
SACTE_1304
SVL: 
Strvi_6068 Strvi_6961
SCT: 
SCAT_1069(aldH)
SCY: 
SCATT_10640
SFA: 
Sfla_4940
SBH: 
SBI_08125
SHY: 
SHJG_3333
SHO: 
SHJGH_3098
SVE: 
SVEN_1516
SDV: 
BN159_6637
SALB: 
XNR_4954
SALS: 
SLNWT_3889 SLNWT_5169
STRP: 
F750_1741
SFI: 
SFUL_1445
SCI: 
B446_09735
SRC: 
M271_36920 M271_42100
SALU: 
DC74_2375
SALL: 
SAZ_13230
SLV: 
SLIV_28360
SGU: 
SGLAU_08360
SVT: 
SVTN_09040
STRE: 
GZL_06632
SCW: 
TU94_07955
SXI: 
SXIM_08460
STRM: 
M444_09735
STRC: 
AA958_05410
SAMB: 
SAM23877_1946(aldH)
SPRI: 
SPRI_6598
SCZ: 
ABE83_05080 ABE83_28580
SCX: 
AS200_33840
SRW: 
TUE45_02355(aldH)
STRF: 
ASR50_09120
SLE: 
sle_52630(sle_52630)
SRN: 
A4G23_01098(aldH)
CMI: 
CMM_0812
CMS: 
CMS0069
MCW: 
A8L33_01720
MPAL: 
BO218_08130 BO218_12285
AGY: 
ATC03_04975 ATC03_15645
ART: 
Arth_3335
ARR: 
ARUE_c34530(aldH)
ARM: 
ART_2596
ARI: 
UM93_13775
ARE: 
AL755_00525
AAQ: 
AOC05_16125
ARW: 
MB46_17645
ARZ: 
AUT26_15885
AAU: 
AAur_3317(aldH)
ACH: 
Achl_3135
APN: 
Asphe3_32640
PSUL: 
AU252_14625
RSA: 
RSal33209_1814
BCV: 
Bcav_0786
LMOI: 
VV02_11040
MPH: 
MLP_07890 MLP_19760
NCA: 
Noca_0086
KFL: 
Kfla_6632
TFU: 
Tfu_1706
NDA: 
Ndas_5346
NAL: 
B005_1809
SRO: 
Sros_1486
FRE: 
Franean1_4676
GOB: 
Gobs_2395
SEN: 
SACE_1997 SACE_2783
AMD: 
AMED_5971
AMN: 
RAM_30625
AMM: 
AMES_5887
AMZ: 
B737_5887
AOI: 
AORI_3623(aldH) AORI_4998(aldH)
AJA: 
AJAP_14530 AJAP_21020
AMQ: 
AMETH_6878
ALU: 
BB31_04690 BB31_37715
PDX: 
Psed_4281
PHH: 
AFB00_20980
AMI: 
Amir_1484 Amir_4721
KAL: 
KALB_6874
KPHY: 
AOZ06_14455
LED: 
BBK82_01545 BBK82_46985
AHM: 
TL08_12515
ACTI: 
UA75_13535
ACAD: 
UA74_13450
AMS: 
AMIS_59920
CAI: 
Caci_7805
SNA: 
Snas_4113
TBI: 
Tbis_1086 Tbis_1743
CWO: 
Cwoe_3952
RBA: 
RB1887
FTE: 
Fluta_2463
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Ahvazi B, Coulombe R, Delarge M, Vedadi M, Zhang L, Meighen E, Vrielink A
  Title
Crystal structure of the NADP+-dependent aldehyde dehydrogenase from Vibrio harveyi: structural implications for cofactor specificity and affinity.
  Journal
Biochem J 349 Pt 3:853-61 (2000)
DOI:10.1042/bj3490853
LinkDB All DBs

KEGG   ENZYME: 1.2.1.63Help
Entry
EC 1.2.1.63                 Enzyme                                 

Name
6-oxohexanoate dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
6-oxohexanoate:NADP+ oxidoreductase
Reaction(IUBMB)
6-oxohexanoate + NADP+ + H2O = adipate + NADPH + 2 H+ [RN:R05099]
Reaction(KEGG)
Substrate
6-oxohexanoate [CPD:C06102];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
adipate [CPD:C06104];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Last step in the cyclohexanol degradation pathway in Acinetobacter sp.
History
EC 1.2.1.63 created 2000
Pathway
Caprolactam degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K19962  
6-oxohexanoate dehydrogenase
Genes
PPJ: 
Taxonomy
Reference
1  [PMID:856571]
  Authors
Davey JF, Trudgill PW.
  Title
The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species.
  Journal
Eur. J. Biochem. 74 (1977) 115-27.
Reference
2  [PMID:1261]
  Authors
Donoghue NA, Trudgill PW.
  Title
The metabolism of cyclohexanol by Acinetobacter NCIB 9871.
  Journal
Eur. J. Biochem. 60 (1975) 1-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
62628-29-9
LinkDB All DBs

KEGG   ENZYME: 1.2.1.4Help
Entry
EC 1.2.1.4                  Enzyme                                 

Name
aldehyde dehydrogenase (NADP+);
NADP-acetaldehyde dehydrogenase;
NADP-dependent aldehyde dehydrogenase;
aldehyde dehydrogenase (NADP)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
aldehyde:NADP+ oxidoreductase
Reaction(IUBMB)
an aldehyde + NADP+ + H2O = a carboxylate + NADPH + H+ [RN:R00634]
Reaction(KEGG)
Substrate
aldehyde [CPD:C00071];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
carboxylate [CPD:C00060];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.2.1.4 created 1961
Pathway
Caprolactam degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K14519  
NADP-dependent aldehyde dehydrogenase
Genes
POL: 
AAV: 
AAA: 
PDE: 
HBA: 
MGO: 
NBR: 
RHA: 
REB: 
ROP: 
ROA: 
Pd630_LPD07647
GPO: 
GPOL_c08310
SCO: 
SCO1871(SCI39.18c)
SMA: 
SAV_6389
SGR: 
SGR_1630 SGR_5625
SGB: 
WQO_07195
SCB: 
SCAB_70651
SSX: 
SACTE_1304
SVL: 
Strvi_6068 Strvi_6961
SCT: 
SCAT_1069(aldH)
SCY: 
SCATT_10640
SFA: 
Sfla_4940
SBH: 
SBI_08125
SHY: 
SHJG_3333
SHO: 
SHJGH_3098
SVE: 
SVEN_1516
SDV: 
BN159_6637
SALB: 
XNR_4954
SALS: 
SLNWT_3889 SLNWT_5169
STRP: 
F750_1741
SFI: 
SFUL_1445
SCI: 
B446_09735
SRC: 
M271_36920 M271_42100
SALU: 
DC74_2375
SALL: 
SAZ_13230
SLV: 
SLIV_28360
SGU: 
SGLAU_08360
SVT: 
SVTN_09040
STRE: 
GZL_06632
SCW: 
TU94_07955
SXI: 
SXIM_08460
STRM: 
M444_09735
STRC: 
AA958_05410
SAMB: 
SAM23877_1946(aldH)
SPRI: 
SPRI_6598
SCZ: 
ABE83_05080 ABE83_28580
SCX: 
AS200_33840
SRW: 
TUE45_02355(aldH)
STRF: 
ASR50_09120
SLE: 
sle_52630(sle_52630)
SRN: 
A4G23_01098(aldH)
CMI: 
CMM_0812
CMS: 
CMS0069
MCW: 
A8L33_01720
MPAL: 
BO218_08130 BO218_12285
AGY: 
ATC03_04975 ATC03_15645
ART: 
Arth_3335
ARR: 
ARUE_c34530(aldH)
ARM: 
ART_2596
ARI: 
UM93_13775
ARE: 
AL755_00525
AAQ: 
AOC05_16125
ARW: 
MB46_17645
ARZ: 
AUT26_15885
AAU: 
AAur_3317(aldH)
ACH: 
Achl_3135
APN: 
Asphe3_32640
PSUL: 
AU252_14625
RSA: 
RSal33209_1814
BCV: 
Bcav_0786
LMOI: 
VV02_11040
MPH: 
MLP_07890 MLP_19760
NCA: 
Noca_0086
KFL: 
Kfla_6632
TFU: 
Tfu_1706
NDA: 
Ndas_5346
NAL: 
B005_1809
SRO: 
Sros_1486
FRE: 
Franean1_4676
GOB: 
Gobs_2395
SEN: 
SACE_1997 SACE_2783
AMD: 
AMED_5971
AMN: 
RAM_30625
AMM: 
AMES_5887
AMZ: 
B737_5887
AOI: 
AORI_3623(aldH) AORI_4998(aldH)
AJA: 
AJAP_14530 AJAP_21020
AMQ: 
AMETH_6878
ALU: 
BB31_04690 BB31_37715
PDX: 
Psed_4281
PHH: 
AFB00_20980
AMI: 
Amir_1484 Amir_4721
KAL: 
KALB_6874
KPHY: 
AOZ06_14455
LED: 
BBK82_01545 BBK82_46985
AHM: 
TL08_12515
ACTI: 
UA75_13535
ACAD: 
UA74_13450
AMS: 
AMIS_59920
CAI: 
Caci_7805
SNA: 
Snas_4113
TBI: 
Tbis_1086 Tbis_1743
CWO: 
Cwoe_3952
RBA: 
RB1887
FTE: 
Fluta_2463
 » show all
Taxonomy
Reference
1
  Authors
Adachi, O., Matsushita, K., Shinagawa, E. and Ameyama, M.
  Title
Crystallization and properties of NADP-dependent aldehyde dehydrogenase from Gluconobacter melanogenus.
  Journal
Agric. Biol. Chem. 44 (1980) 155-164.
Reference
2
  Authors
Jakoby, W.B.
  Title
Aldehyde dehydrogenases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
Reference
3
  Authors
Nakayama, T.
  Title
Acetic acid bacteria. II. Intracellular distribution of enzymes related to acetic acid fermentation, and some properties of a highly purified triphosphopyridine nucleotide (TPN)-dependent aldehyde dehydrogenase.
  Journal
J. Biochem. (Tokyo) 48 (1960) 812-830.
Reference
4  [PMID:13061400]
  Authors
SEEGMILLER JE.
  Title
Triphosphopyridine nucleotide-linked aldehyde dehydrogenase from yeast.
  Journal
J. Biol. Chem. 201 (1953) 629-37.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-87-9
LinkDB All DBs

KEGG   REACTION: R05099Help
Entry
R05099                      Reaction                               

Name
6-oxohexanoate:NADP+ oxidoreductase
Definition
Adipate semialdehyde + NADP+ + H2O <=> Adipate + NADPH + H+
Equation
Reaction class
C00005_C00006
C06102_C06104
Enzyme
1.2.1.4         1.2.1.63
Pathway
Caprolactam degradation
Metabolic pathways
Microbial metabolism in diverse environments
Degradation of aromatic compounds
Orthology
K14519  
NADP-dependent aldehyde dehydrogenase [EC:1.2.1.4]
K19962  
6-oxohexanoate dehydrogenase [EC:1.2.1.63]
Other DBs
RHEA: 
LinkDB All DBs

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