| Entry |
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| Name |
4-hydroxyacetophenone monooxygenase;
HAPMO
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
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| Sysname |
(4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming)
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| Reaction(IUBMB) |
(4-hydroxyphenyl)ethan-1-one + NADPH + H+ + O2 = 4-hydroxyphenyl acetate + NADP+ + H2O [RN: R06892]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Contains FAD. The enzyme from Pseudomonas fluorescens ACB catalyses the conversion of a wide range of acetophenone derivatives. Highest activity occurs with compounds bearing an electron-donating substituent at the para position of the aromatic ring [1]. In the absence of substrate, the enzyme can act as an NAD(P)H oxidase (EC 1.6.3.1).
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| History |
EC 1.14.13.84 created 2004
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| Pathway |
| Bisphenol degradation | | Metabolic pathways | | Microbial metabolism in diverse environments |
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| Orthology |
| 4-hydroxyacetophenone monooxygenase |
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| Genes |
PALK: | | GAG: | | GPS: | | HJA: | | BGE: | | BXE: | | BXB: | | PVE: | | BHZ: | | AXY: | | HYB: | | MESO: | | RHI: | | SAME: | | REL: | | REI: | | RTR: | | RGA: | | BJA: | | BJU: | | BJP: | | BRS: | | BRC: | | BIC: | | MMED: | | RBM: | | PZU: | | NAR: | | NPN: | | SPHP: | | STER: | | SWI: | | SPHM: | | SMY: | | SJP: | | SCH: | | SPMI: | | SPHB: | | SINB: | | AEP: | | TMO: | | MCX: | | MPA: | | MAO: | | MAVI: | | MAVU: | | MAV: | | MAVD: | | MAVR: | | MAVA: | | MIT: | | MIA: | | MIE: | | MIR: | | MID: | | MYO: | | MCHI: | | MSA: | | MVA: | | MGI: | | MSP: | | MCHE: | | MMC: | | MKM: | | MJL: | | MJD: | | MMI: | | MMAE: | | MRH: | | MMM: | | MCB: | | MLI: | | MKN: | | MKS: | | MKI: | | MNE: | | MYV: | | MYE: | | MFT: | | MPHL: | | MVQ: | | NNO: | | RHA: | | REY: | | ROP: | | REQ: | | RHB: | | RFA: | | GOR: | | GTA: | | MIO: | | ARZ: | | FRI: | | PDX: | | AYM: | | ABAI: | |
» show all
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| Reference |
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| Authors |
Kamerbeek NM, Moonen MJ, Van Der Ven JG, Van Berkel WJ, Fraaije MW, Janssen DB. |
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| Title |
4-Hydroxyacetophenone monooxygenase from Pseudomonas fluorescens ACB. A novel flavoprotein catalyzing Baeyer-Villiger oxidation of aromatic compounds. |
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| Journal |
Eur. J. Biochem. 268 (2001) 2547-57. |
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| Sequence |
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| Reference |
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| Authors |
Kamerbeek NM, Olsthoorn AJ, Fraaije MW, Janssen DB. |
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| Title |
Substrate specificity and enantioselectivity of 4-hydroxyacetophenone monooxygenase. |
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| Journal |
Appl. Environ. Microbiol. 69 (2003) 419-26. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 156621-13-5 |
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| LinkDB |
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