KEGG ORTHOLOGY: K14579

ORTHOLOGY: K14579

Entry

K14579 KO

Name

nahAc, ndoB, nbzAc, dntAc

Definition

naphthalene 1,2-dioxygenase subunit alpha [EC:1.14.12.12 1.14.12.23 1.14.12.24]

Pathway

ko00624	Polycyclic aromatic hydrocarbon degradation
ko00626	Naphthalene degradation
ko00627	Aminobenzoate degradation
ko00633	Nitrotoluene degradation
ko00642	Ethylbenzene degradation
ko01220	Degradation of aromatic compounds

Module

M00534

Naphthalene degradation, naphthalene => salicylate

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K14579  nahAc, ndoB, nbzAc, dntAc; naphthalene 1,2-dioxygenase subunit alpha
  Xenobiotics biodegradation and metabolism
   00627 Aminobenzoate degradation
    K14579  nahAc, ndoB, nbzAc, dntAc; naphthalene 1,2-dioxygenase subunit alpha
   00633 Nitrotoluene degradation
    K14579  nahAc, ndoB, nbzAc, dntAc; naphthalene 1,2-dioxygenase subunit alpha
   00642 Ethylbenzene degradation
    K14579  nahAc, ndoB, nbzAc, dntAc; naphthalene 1,2-dioxygenase subunit alpha
   00626 Naphthalene degradation
    K14579  nahAc, ndoB, nbzAc, dntAc; naphthalene 1,2-dioxygenase subunit alpha
   00624 Polycyclic aromatic hydrocarbon degradation
    K14579  nahAc, ndoB, nbzAc, dntAc; naphthalene 1,2-dioxygenase subunit alpha
KEGG modules [BR:ko00002]
Pathway module
  Secondary metabolism
   Aromatics degradation
    M00534  Naphthalene degradation, naphthalene => salicylate
     K14579  nahAc, ndoB, nbzAc, dntAc; naphthalene 1,2-dioxygenase subunit alpha
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.12  With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
    1.14.12.12  naphthalene 1,2-dioxygenase
     K14579  nahAc, ndoB, nbzAc, dntAc; naphthalene 1,2-dioxygenase subunit alpha
    1.14.12.23  nitroarene dioxygenase
     K14579  nahAc, ndoB, nbzAc, dntAc; naphthalene 1,2-dioxygenase subunit alpha
    1.14.12.24  2,4-dinitrotoluene dioxygenase
     K14579  nahAc, ndoB, nbzAc, dntAc; naphthalene 1,2-dioxygenase subunit alpha

Other DBs

RN:

R02968 R05422 R05423 R05424 R05425 R05426 R05427 R06909 R06930 R06937 R07704 R07706 R09159 R09233

GO:

0018625

Genes

PSC:	A458_06725
PSTU:	UIB01_22625
PBM:	CL52_14610
ALT:	ambt_17895
BMK:	DM80_1443(ndoB)
PNA:	Pnap_2485
AJS:	Ajs_3092
AG:	AAB09766(dntAc) AAL76202(nbzAc) AAO64274(nahAc) ADQ90222(cnbAc) AGH09226(mntAc)

Reference

PMID:8486285

Authors

Simon MJ, Osslund TD, Saunders R, Ensley BD, Suggs S, Harcourt A, Suen WC, Cruden DL, Gibson DT, Zylstra GJ

Title

Sequences of genes encoding naphthalene dioxygenase in Pseudomonas putida strains G7 and NCIB 9816-4.

Journal

Gene 127:31-7 (1993)
DOI:10.1016/0378-1119(93)90613-8

Reference

PMID:15288784

Authors

Dennis JJ, Zylstra GJ

Title

Complete sequence and genetic organization of pDTG1, the 83 kilobase naphthalene degradation plasmid from Pseudomonas putida strain NCIB 9816-4.

Journal

J Mol Biol 341:753-68 (2004)
DOI:10.1016/j.jmb.2004.06.034

Sequence

[ag:AAO64274]

Reference

PMID:11823201

Authors

Lessner DJ, Johnson GR, Parales RE, Spain JC, Gibson DT

Title

Molecular characterization and substrate specificity of nitrobenzene dioxygenase from Comamonas sp. strain JS765.

Journal

Appl Environ Microbiol 68:634-41 (2002)
DOI:10.1128/AEM.68.2.634-641.2002

Sequence

[ag:AAL76202]

Reference

PMID:8759857

Authors

Suen WC, Haigler BE, Spain JC

Title

2,4-Dinitrotoluene dioxygenase from Burkholderia sp. strain DNT: similarity to naphthalene dioxygenase.

Journal

J Bacteriol 178:4926-34 (1996)
DOI:10.1128/JB.178.16.4926-4934.1996

Sequence

[ag:AAB09766]

LinkDB

ORTHOLOGY: K14580

Entry

K14580 KO

Name

nahAd, ndoC, nbzAd, dntAd

Definition

naphthalene 1,2-dioxygenase subunit beta [EC:1.14.12.12 1.14.12.23 1.14.12.24]

Pathway

ko00624	Polycyclic aromatic hydrocarbon degradation
ko00626	Naphthalene degradation
ko00627	Aminobenzoate degradation
ko00633	Nitrotoluene degradation
ko00642	Ethylbenzene degradation
ko01220	Degradation of aromatic compounds

Module

M00534

Naphthalene degradation, naphthalene => salicylate

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K14580  nahAd, ndoC, nbzAd, dntAd; naphthalene 1,2-dioxygenase subunit beta
  Xenobiotics biodegradation and metabolism
   00627 Aminobenzoate degradation
    K14580  nahAd, ndoC, nbzAd, dntAd; naphthalene 1,2-dioxygenase subunit beta
   00633 Nitrotoluene degradation
    K14580  nahAd, ndoC, nbzAd, dntAd; naphthalene 1,2-dioxygenase subunit beta
   00642 Ethylbenzene degradation
    K14580  nahAd, ndoC, nbzAd, dntAd; naphthalene 1,2-dioxygenase subunit beta
   00626 Naphthalene degradation
    K14580  nahAd, ndoC, nbzAd, dntAd; naphthalene 1,2-dioxygenase subunit beta
   00624 Polycyclic aromatic hydrocarbon degradation
    K14580  nahAd, ndoC, nbzAd, dntAd; naphthalene 1,2-dioxygenase subunit beta
KEGG modules [BR:ko00002]
Pathway module
  Secondary metabolism
   Aromatics degradation
    M00534  Naphthalene degradation, naphthalene => salicylate
     K14580  nahAd, ndoC, nbzAd, dntAd; naphthalene 1,2-dioxygenase subunit beta
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.12  With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
    1.14.12.12  naphthalene 1,2-dioxygenase
     K14580  nahAd, ndoC, nbzAd, dntAd; naphthalene 1,2-dioxygenase subunit beta
    1.14.12.23  nitroarene dioxygenase
     K14580  nahAd, ndoC, nbzAd, dntAd; naphthalene 1,2-dioxygenase subunit beta
    1.14.12.24  2,4-dinitrotoluene dioxygenase
     K14580  nahAd, ndoC, nbzAd, dntAd; naphthalene 1,2-dioxygenase subunit beta

Other DBs

RN:

R02968 R05422 R05423 R05424 R05425 R05426 R05427 R06909 R06930 R06937 R07704 R07706 R09159 R09233

GO:

0018625

Genes

PSC:	A458_06720
PSTU:	UIB01_22630
PBM:	CL52_14615
ALT:	ambt_17890
RMN:	TK49_07955
BMK:	DM80_1444(ndoC)
PNA:	Pnap_2484
AJS:	Ajs_3093
AG:	AAB09767(dntAd) AAL76203(nbzAd) AAO64275(nahAd) ADQ90223(cnbAd) AGH09227(mntAd)

Reference

PMID:8486285

Authors

Simon MJ, Osslund TD, Saunders R, Ensley BD, Suggs S, Harcourt A, Suen WC, Cruden DL, Gibson DT, Zylstra GJ

Title

Sequences of genes encoding naphthalene dioxygenase in Pseudomonas putida strains G7 and NCIB 9816-4.

Journal

Gene 127:31-7 (1993)
DOI:10.1016/0378-1119(93)90613-8

Reference

PMID:15288784

Authors

Dennis JJ, Zylstra GJ

Title

Complete sequence and genetic organization of pDTG1, the 83 kilobase naphthalene degradation plasmid from Pseudomonas putida strain NCIB 9816-4.

Journal

J Mol Biol 341:753-68 (2004)
DOI:10.1016/j.jmb.2004.06.034

Sequence

[ag:AAO64275]

Reference

PMID:11823201

Authors

Lessner DJ, Johnson GR, Parales RE, Spain JC, Gibson DT

Title

Molecular characterization and substrate specificity of nitrobenzene dioxygenase from Comamonas sp. strain JS765.

Journal

Appl Environ Microbiol 68:634-41 (2002)
DOI:10.1128/AEM.68.2.634-641.2002

Sequence

[ag:AAL76203]

Reference

PMID:8759857

Authors

Suen WC, Haigler BE, Spain JC

Title

2,4-Dinitrotoluene dioxygenase from Burkholderia sp. strain DNT: similarity to naphthalene dioxygenase.

Journal

J Bacteriol 178:4926-34 (1996)
DOI:10.1128/JB.178.16.4926-4934.1996

Sequence

[ag:AAB09767]

LinkDB

ORTHOLOGY: K14578

Entry

K14578 KO

Name

nahAb, nagAb, ndoA, nbzAb, dntAb

Definition

naphthalene 1,2-dioxygenase ferredoxin component

Pathway

ko00624	Polycyclic aromatic hydrocarbon degradation
ko00626	Naphthalene degradation
ko00627	Aminobenzoate degradation
ko00633	Nitrotoluene degradation
ko00642	Ethylbenzene degradation
ko01220	Degradation of aromatic compounds

Module

M00534	Naphthalene degradation, naphthalene => salicylate
M00638	Salicylate degradation, salicylate => gentisate

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K14578  nahAb, nagAb, ndoA, nbzAb, dntAb; naphthalene 1,2-dioxygenase ferredoxin component
  Xenobiotics biodegradation and metabolism
   00627 Aminobenzoate degradation
    K14578  nahAb, nagAb, ndoA, nbzAb, dntAb; naphthalene 1,2-dioxygenase ferredoxin component
   00633 Nitrotoluene degradation
    K14578  nahAb, nagAb, ndoA, nbzAb, dntAb; naphthalene 1,2-dioxygenase ferredoxin component
   00642 Ethylbenzene degradation
    K14578  nahAb, nagAb, ndoA, nbzAb, dntAb; naphthalene 1,2-dioxygenase ferredoxin component
   00626 Naphthalene degradation
    K14578  nahAb, nagAb, ndoA, nbzAb, dntAb; naphthalene 1,2-dioxygenase ferredoxin component
   00624 Polycyclic aromatic hydrocarbon degradation
    K14578  nahAb, nagAb, ndoA, nbzAb, dntAb; naphthalene 1,2-dioxygenase ferredoxin component
KEGG modules [BR:ko00002]
Pathway module
  Secondary metabolism
   Aromatics degradation
    M00534  Naphthalene degradation, naphthalene => salicylate
     K14578  nahAb, nagAb, ndoA, nbzAb, dntAb; naphthalene 1,2-dioxygenase ferredoxin component
    M00638  Salicylate degradation, salicylate => gentisate
     K14578  nahAb, nagAb, ndoA, nbzAb, dntAb; naphthalene 1,2-dioxygenase ferredoxin component

Other DBs

RN:

R02968 R05422 R05423 R05424 R05425 R05426 R05427 R06909 R06930 R06937 R07704 R07706 R07709 R07710 R09159 R09233

COG:

COG2146

Genes

EBT:	EBL_c34290(ndoA)
PSD:	DSC_14870
PSC:	A458_06730
PSTU:	UIB01_22620
PBM:	CL52_14605
PFK:	PFAS1_28605
ALT:	ambt_17920 ambt_18015
MMW:	Mmwyl1_2671
MME:	Marme_2406
MPC:	Mar181_2359
RSO:	RSc1088(nagAb)
RSL:	RPSI07_2303(doxA)
RSN:	RSPO_c02276
RSM:	CMR15_20207(doxA)
RSE:	F504_1059
RPJ:	N234_28715
RMN:	TK49_07940
REU:	Reut_B4721
REH:	H16_A1631(nagI)
CNC:	CNE_1c16390(ndoA) CNE_1c17590 CNE_BB1p12680(ndoA)
CBW:	RR42_s2753
CCUP:	BKK81_31205
BMK:	DM80_1442(ndoA)
BCEP:	APZ15_32860
BPYR:	ABD05_24790
BUB:	BW23_5817(ndoA)
BGL:	bglu_2g20100
BGU:	KS03_3915(ndoA)
BUG:	BC1001_0578
BUQ:	AC233_10895
BXE:	Bxe_C0940
BXB:	DR64_7510(ndoA) DR64_8472
BPX:	BUPH_04468
BFN:	OI25_3048(ndoA)
PSPW:	BJG93_04745
PPK:	U875_04305
PPNO:	DA70_21380
PPNM:	LV28_08940
PRB:	X636_05140
PPUL:	RO07_03170
PSPU:	NA29_24080
PAPI:	SG18_03360
PVE:	UC34_07200 UC34_19325
POX:	MB84_24080
PFG:	AB870_06320
PNR:	AT302_02755
BPA:	BPP2189(ndoA)
BPAR:	BN117_1348(ndoA)
BBR:	BB1586(ndoA)
BBM:	BN115_1540(ndoA)
BBH:	BN112_1870(ndoA)
BBX:	BBS798_1545(ndoA)
BPT:	Bpet2806
AXY:	AXYL_00937 AXYL_06577
AXO:	NH44784_011931
AXN:	AX27061_0964
AXS:	LH59_04745
AXX:	ERS451415_00955(ndoA_1)
ADT:	APT56_05005
AIS:	BUW96_21025
POL:	Bpro_0985
PNA:	Pnap_2461 Pnap_2486
AAV:	Aave_0167
AJS:	Ajs_3091
AAA:	Acav_0198
ACK:	C380_09990
VAP:	Vapar_5347
VPE:	Varpa_2937
VPD:	VAPA_1c07020 VAPA_1c20390
CTES:	O987_21885
LIM:	L103DPR2_01956(ndoA)
LIH:	L63ED372_02713(ndoA)
HYB:	Q5W_18510
HYL:	LPB072_20435
MASW:	AM586_27400
LCH:	Lcho_0795
AZO:	azo2514(nagAb)
MSL:	Msil_1467
JAN:	Jann_3956
SPAN:	AWL63_16080
AZL:	AZL_a09190
ALI:	AZOLI_p20647
TMO:	TMO_a0552(doxA)
NVN:	NVIE_028160
TAA:	NMY3_03310(nagAb_4)
AG:	AAA25905(nahAb) AAB09765(dntAb) AAL76201(nbzAb) AGH09225(mntAb)

» show all

Reference

PMID:8486285

Authors

Simon MJ, Osslund TD, Saunders R, Ensley BD, Suggs S, Harcourt A, Suen WC, Cruden DL, Gibson DT, Zylstra GJ

Title

Sequences of genes encoding naphthalene dioxygenase in Pseudomonas putida strains G7 and NCIB 9816-4.

Journal

Gene 127:31-7 (1993)
DOI:10.1016/0378-1119(93)90613-8

Reference

PMID:15288784

Authors

Dennis JJ, Zylstra GJ

Title

Complete sequence and genetic organization of pDTG1, the 83 kilobase naphthalene degradation plasmid from Pseudomonas putida strain NCIB 9816-4.

Journal

J Mol Biol 341:753-68 (2004)
DOI:10.1016/j.jmb.2004.06.034

Sequence

[ag:AAA25905]

LinkDB

ORTHOLOGY: K14581

Entry

K14581 KO

Name

nahAa, nagAa, ndoR, nbzAa, dntAa

Definition

naphthalene 1,2-dioxygenase ferredoxin reductase component [EC:1.18.1.7]

Pathway

ko00624	Polycyclic aromatic hydrocarbon degradation
ko00626	Naphthalene degradation
ko00627	Aminobenzoate degradation
ko00633	Nitrotoluene degradation
ko00642	Ethylbenzene degradation
ko01220	Degradation of aromatic compounds

Module

M00534	Naphthalene degradation, naphthalene => salicylate
M00638	Salicylate degradation, salicylate => gentisate

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Overview
   01220 Degradation of aromatic compounds
    K14581  nahAa, nagAa, ndoR, nbzAa, dntAa; naphthalene 1,2-dioxygenase ferredoxin reductase component
  Xenobiotics biodegradation and metabolism
   00627 Aminobenzoate degradation
    K14581  nahAa, nagAa, ndoR, nbzAa, dntAa; naphthalene 1,2-dioxygenase ferredoxin reductase component
   00633 Nitrotoluene degradation
    K14581  nahAa, nagAa, ndoR, nbzAa, dntAa; naphthalene 1,2-dioxygenase ferredoxin reductase component
   00642 Ethylbenzene degradation
    K14581  nahAa, nagAa, ndoR, nbzAa, dntAa; naphthalene 1,2-dioxygenase ferredoxin reductase component
   00626 Naphthalene degradation
    K14581  nahAa, nagAa, ndoR, nbzAa, dntAa; naphthalene 1,2-dioxygenase ferredoxin reductase component
   00624 Polycyclic aromatic hydrocarbon degradation
    K14581  nahAa, nagAa, ndoR, nbzAa, dntAa; naphthalene 1,2-dioxygenase ferredoxin reductase component
KEGG modules [BR:ko00002]
Pathway module
  Secondary metabolism
   Aromatics degradation
    M00534  Naphthalene degradation, naphthalene => salicylate
     K14581  nahAa, nagAa, ndoR, nbzAa, dntAa; naphthalene 1,2-dioxygenase ferredoxin reductase component
    M00638  Salicylate degradation, salicylate => gentisate
     K14581  nahAa, nagAa, ndoR, nbzAa, dntAa; naphthalene 1,2-dioxygenase ferredoxin reductase component
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.18  Acting on iron-sulfur proteins as donors
   1.18.1  With NAD+ or NADP+ as acceptor
    1.18.1.7  ferredoxin---NAD(P)+ reductase (naphthalene dioxygenase ferredoxin-specific)
     K14581  nahAa, nagAa, ndoR, nbzAa, dntAa; naphthalene 1,2-dioxygenase ferredoxin reductase component

Other DBs

RN:

R02968 R05422 R05423 R05424 R05425 R05426 R05427 R06909 R06930 R06937 R07704 R07706 R07709 R07710 R09159 R09233

Genes

EBT:	EBL_c34260(ndoR)
PSC:	A458_06735
PSTU:	UIB01_22615
PBM:	CL52_14600
PFK:	PFAS1_28600
ALT:	ambt_18035
MMW:	Mmwyl1_2668
MME:	Marme_2403
MPC:	Mar181_2356
RSO:	RSc1091(nagAa)
RSL:	RPSI07_2300(ndoR)
RSN:	RSPO_c02273
RSM:	CMR15_20210(ndoR)
RSE:	F504_1062
RPJ:	N234_28700
RMN:	TK49_07925
CBW:	RR42_s2750
CCUP:	BKK81_31190
BMK:	DM80_1434(ndoR) DM80_1439(ndoR)
BUG:	BC1001_0575
BUQ:	AC233_10920
BPX:	BUPH_04465
BFN:	OI25_3043(ndoR)
PPK:	U875_04290
PPNO:	DA70_21365
PPNM:	LV28_08955
PRB:	X636_05155
PPUL:	RO07_03185
PSPU:	NA29_24095
PAPI:	SG18_03375
PVE:	UC34_19340
POX:	MB84_24095
PFG:	AB870_06335
PNR:	AT302_02770
AXY:	AXYL_06582
POL:	Bpro_0980
PNA:	Pnap_2489
AAV:	Aave_0164
AJS:	Ajs_3089
AAA:	Acav_0195
ACK:	C380_10005
VPE:	Varpa_2932
LCH:	Lcho_0800
THI:	THI_2205
AZO:	azo2517(nagAa)
SIX:	BSY16_5589
OAH:	DR92_4202
RBM:	TEF_01260
PYE:	A6J80_03590
SGI:	SGRAN_2805(thnY)
TMO:	TMO_2240(ndoR)
AG:	AAA25904(nahAa) AAB09763(dntAa) AAD12606(nagAa) AAL76199(nbzAa) AGH09224(mntAa)

» show all

Reference

PMID:8486285

Authors

Simon MJ, Osslund TD, Saunders R, Ensley BD, Suggs S, Harcourt A, Suen WC, Cruden DL, Gibson DT, Zylstra GJ

Title

Sequences of genes encoding naphthalene dioxygenase in Pseudomonas putida strains G7 and NCIB 9816-4.

Journal

Gene 127:31-7 (1993)
DOI:10.1016/0378-1119(93)90613-8

Reference

PMID:15288784

Authors

Dennis JJ, Zylstra GJ

Title

Complete sequence and genetic organization of pDTG1, the 83 kilobase naphthalene degradation plasmid from Pseudomonas putida strain NCIB 9816-4.

Journal

J Mol Biol 341:753-68 (2004)
DOI:10.1016/j.jmb.2004.06.034

Sequence

[ag:AAA25904]

LinkDB

ENZYME: 1.14.12.12

Entry

EC 1.14.12.12 Enzyme

Name

naphthalene 1,2-dioxygenase;
naphthalene dioxygenase;
naphthalene oxygenase;
NDO

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor

Sysname

naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)

Reaction(IUBMB)

naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+ [RN:R02968]

Reaction(KEGG)

R02968;
(other) R05422 R05423 R05424 R05425 R05426 R05427 R06909 R06930 R06937 R07704 R09159

Substrate

naphthalene [CPD:C00829];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]

Product

(1R,2S)-1,2-dihydronaphthalene-1,2-diol [CPD:C04314];
NAD+ [CPD:C00003]

Comment

This enzyme is a member of the ring-hydroxylating dioxygenase (RHD) family of bacterial enzymes that play a critical role in the degradation of aromatic compounds, such as polycyclic aromatic hydrocarbons [5]. This enzyme comprises a multicomponent system, containing a reductase that is an iron-sulfur flavoprotein (FAD; EC 1.18.1.3, ferredoxin---NAD+ reductase), an iron-sulfur oxygenase, and ferredoxin. Requires Fe2+.

History

EC 1.14.12.12 created 1992

Pathway

ec00624	Polycyclic aromatic hydrocarbon degradation
ec00626	Naphthalene degradation
ec00642	Ethylbenzene degradation
ec01100	Metabolic pathways
ec01120	Microbial metabolism in diverse environments

Orthology

K14579	naphthalene 1,2-dioxygenase subunit alpha
K14580	naphthalene 1,2-dioxygenase subunit beta

Genes

PSC:	A458_06720 A458_06725
PSTU:	UIB01_22625 UIB01_22630
PBM:	CL52_14610 CL52_14615
ALT:	ambt_17890 ambt_17895
RMN:	TK49_07955
BMK:	DM80_1443(ndoB) DM80_1444(ndoC)
PNA:	Pnap_2484 Pnap_2485
AJS:	Ajs_3092 Ajs_3093

Reference

1 [PMID:6874638]

Authors

Ensley BD, Gibson DT.

Title

Naphthalene dioxygenase: purification and properties of a terminal oxygenase component.

Journal

J. Bacteriol. 155 (1983) 505-11.

Reference

2 [PMID:234247]

Authors

Jeffrey AM, Yeh HJ, Jerina DM, Patel TR, Davey JF, Gibson DT.

Title

Initial reactions in the oxidation of naphthalene by Pseudomonas putida.

Journal

Biochemistry. 14 (1975) 575-84.

Reference

3 [PMID:9634695]

Authors

Kauppi B, Lee K, Carredano E, Parales RE, Gibson DT, Eklund H, Ramaswamy S

Title

Structure of an aromatic-ring-hydroxylating dioxygenase-naphthalene 1,2-dioxygenase.

Journal

Structure. 6 (1998) 571-86.

Reference

4 [PMID:10692370]

Authors

Parales RE, Lee K, Resnick SM, Jiang H, Lessner DJ, Gibson DT

Title

Substrate specificity of naphthalene dioxygenase: effect of specific amino acids at the active site of the enzyme.

Journal

J. Bacteriol. 182 (2000) 1641-9.

Reference

5 [PMID:17014090]

Authors

Jouanneau Y, Meyer C, Jakoncic J, Stojanoff V, Gaillard J

Title

Characterization of a naphthalene dioxygenase endowed with an exceptionally broad substrate specificity toward polycyclic aromatic hydrocarbons.

Journal

Biochemistry. 45 (2006) 12380-91.

Other DBs

ExplorEnz - The Enzyme Database:

1.14.12.12

IUBMB Enzyme Nomenclature:

1.14.12.12

ExPASy - ENZYME nomenclature database:

1.14.12.12

UM-BBD (Biocatalysis/Biodegradation Database):

1.14.12.12

BRENDA, the Enzyme Database:

1.14.12.12

CAS:

9074-04-8

LinkDB

REACTION: R05427

Entry

R05427 Reaction

Definition

2 Acetophenone + Oxygen <=> 2 2-Hydroxyacetophenone

Equation

2 C07113 + C00007 <=> 2 C07189

Reaction class

RC00157

C07113_C07189

Enzyme

1.14.12.12

Pathway

rn00642	Ethylbenzene degradation
rn01120	Microbial metabolism in diverse environments

Orthology

K14578	naphthalene 1,2-dioxygenase ferredoxin component
K14579	naphthalene 1,2-dioxygenase subunit alpha [EC:1.14.12.12 1.14.12.23 1.14.12.24]
K14580	naphthalene 1,2-dioxygenase subunit beta [EC:1.14.12.12 1.14.12.23 1.14.12.24]
K14581	naphthalene 1,2-dioxygenase ferredoxin reductase component [EC:1.18.1.7]

LinkDB

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