naphthalene 1,2-dioxygenase subunit alpha [EC:1.14.12.12 1.14.12.23 1.14.12.24]

PMID:8486285

Simon MJ, Osslund TD, Saunders R, Ensley BD, Suggs S, Harcourt A, Suen WC, Cruden DL, Gibson DT, Zylstra GJ

Sequences of genes encoding naphthalene dioxygenase in Pseudomonas putida strains G7 and NCIB 9816-4.

Gene 127:31-7 (1993)
DOI:10.1016/0378-1119(93)90613-8

PMID:15288784

Dennis JJ, Zylstra GJ

Complete sequence and genetic organization of pDTG1, the 83 kilobase naphthalene  degradation plasmid from Pseudomonas putida strain NCIB 9816-4.

J Mol Biol 341:753-68 (2004)
DOI:10.1016/j.jmb.2004.06.034

[ag:AAO64274]

PMID:11823201

Lessner DJ, Johnson GR, Parales RE, Spain JC, Gibson DT

Molecular characterization and substrate specificity of nitrobenzene dioxygenase  from Comamonas sp. strain JS765.

Appl Environ Microbiol 68:634-41 (2002)
DOI:10.1128/AEM.68.2.634-641.2002

[ag:AAL76202]

PMID:8759857

Suen WC, Haigler BE, Spain JC

2,4-Dinitrotoluene dioxygenase from Burkholderia sp. strain DNT: similarity to naphthalene dioxygenase.

J Bacteriol 178:4926-34 (1996)
DOI:10.1128/JB.178.16.4926-4934.1996

[ag:AAB09766]

naphthalene 1,2-dioxygenase subunit beta [EC:1.14.12.12 1.14.12.23 1.14.12.24]

PMID:8486285

Simon MJ, Osslund TD, Saunders R, Ensley BD, Suggs S, Harcourt A, Suen WC, Cruden DL, Gibson DT, Zylstra GJ

Sequences of genes encoding naphthalene dioxygenase in Pseudomonas putida strains G7 and NCIB 9816-4.

Gene 127:31-7 (1993)
DOI:10.1016/0378-1119(93)90613-8

PMID:15288784

Dennis JJ, Zylstra GJ

Complete sequence and genetic organization of pDTG1, the 83 kilobase naphthalene  degradation plasmid from Pseudomonas putida strain NCIB 9816-4.

J Mol Biol 341:753-68 (2004)
DOI:10.1016/j.jmb.2004.06.034

[ag:AAO64275]

PMID:11823201

Lessner DJ, Johnson GR, Parales RE, Spain JC, Gibson DT

Molecular characterization and substrate specificity of nitrobenzene dioxygenase  from Comamonas sp. strain JS765.

Appl Environ Microbiol 68:634-41 (2002)
DOI:10.1128/AEM.68.2.634-641.2002

[ag:AAL76203]

PMID:8759857

Suen WC, Haigler BE, Spain JC

2,4-Dinitrotoluene dioxygenase from Burkholderia sp. strain DNT: similarity to naphthalene dioxygenase.

J Bacteriol 178:4926-34 (1996)
DOI:10.1128/JB.178.16.4926-4934.1996

[ag:AAB09767]

naphthalene 1,2-dioxygenase ferredoxin component

PMID:8486285

Simon MJ, Osslund TD, Saunders R, Ensley BD, Suggs S, Harcourt A, Suen WC, Cruden DL, Gibson DT, Zylstra GJ

Sequences of genes encoding naphthalene dioxygenase in Pseudomonas putida strains G7 and NCIB 9816-4.

Gene 127:31-7 (1993)
DOI:10.1016/0378-1119(93)90613-8

PMID:15288784

Dennis JJ, Zylstra GJ

Complete sequence and genetic organization of pDTG1, the 83 kilobase naphthalene  degradation plasmid from Pseudomonas putida strain NCIB 9816-4.

J Mol Biol 341:753-68 (2004)
DOI:10.1016/j.jmb.2004.06.034

[ag:AAA25905]

effector protein LidA

PMID:20375353

Newton HJ, Ang DK, van Driel IR, Hartland EL

Molecular pathogenesis of infections caused by Legionella pneumophila.

Clin Microbiol Rev 23:274-98 (2010)
DOI:10.1128/CMR.00052-09

PMID:16824952

Machner MP, Isberg RR

Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila.

Dev Cell 11:47-56 (2006)
DOI:10.1016/j.devcel.2006.05.013

PMID:20929312

Hubber A, Roy CR

Modulation of host cell function by Legionella pneumophila type IV effectors.

Annu Rev Cell Dev Biol 26:261-83 (2010)
DOI:10.1146/annurev-cellbio-100109-104034

[lpn:lpg0940]

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor

nitrobenzene,NADH:oxygen oxidoreductase (1,2-hydroxylating, nitrite-releasing)

nitrobenzene + NADH + O2 = catechol + nitrite + NAD+ [RN:R07706]

R07706

nitrobenzene [CPD:C06813];
NADH [CPD:C00004];
O2 [CPD:C00007]

This enzyme is a member of the naphthalene family of bacterial Rieske non-heme iron dioxygenases. It comprises a multicomponent system, containing a Rieske [2Fe-2S] ferredoxin, an NADH-dependent flavoprotein reductase (EC 1.18.1.3, ferredoxin---NAD+ reductase), and an alpha3beta3 oxygenase. The enzyme forms of a cis-dihydroxylated product that spontaneously rearranges to form a catechol with accompanying release of nitrite. It can typically act on many different nitroaromatic compounds, including chlorinated species. Enzymes found in different strains may have different substrate preferences. Requires Fe2+.

EC 1.14.12.23 created 2015

1  [PMID:9495758]

Parales JV, Parales RE, Resnick SM, Gibson DT

Enzyme specificity of 2-nitrotoluene 2,3-dioxygenase from Pseudomonas sp. strain  JS42 is determined by the C-terminal region of the alpha subunit of the oxygenase component.

J. Bacteriol. 180 (1998) 1194-9.

2  [PMID:11823201]

Lessner DJ, Johnson GR, Parales RE, Spain JC, Gibson DT

Molecular characterization and substrate specificity of nitrobenzene dioxygenase  from Comamonas sp. strain JS765.

Appl. Environ. Microbiol. 68 (2002) 634-41.

[ag:AAL76202 AAL76203]

3  [PMID:21602392]

Liu H, Wang SJ, Zhang JJ, Dai H, Tang H, Zhou NY

Patchwork assembly of nag-like nitroarene dioxygenase genes and the 3-chlorocatechol degradation cluster for evolution of the 2-chloronitrobenzene catabolism pathway in Pseudomonas stutzeri ZWLR2-1.

Appl. Environ. Microbiol. 77 (2011) 4547-52.

[ag:ADQ90222 ADQ90223]

4  [PMID:24491551]

Singh D, Kumari A, Ramaswamy S, Ramanathan G

Expression, purification and substrate specificities of 3-nitrotoluene dioxygenase from Diaphorobacter sp. strain DS2.

Biochem. Biophys. Res. Commun. 445 (2014) 36-42.

[ag:AGH09226 AGH09227]