| Entry |
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| Name |
hydroquinone 1,2-dioxygenase;
hydroquinone dioxygenase;
benzene-1,4-diol:oxygen 1,2-oxidoreductase (decyclizing)
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| Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
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| Sysname |
benzene-1,4-diol:oxygen 1,2-oxidoreductase (ring-opening)
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| Reaction(IUBMB) |
benzene-1,4-diol + O2 = (2Z,4E)-4-hydroxy-6-oxohexa-2,4-dienoate [RN: R05246]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
(2Z,4E)-4-hydroxy-6-oxohexa-2,4-dienoate
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| Comment |
The enzyme is an extradiol-type dioxygenase, and is a member of the nonheme-iron(II)-dependent dioxygenase family. It catalyses the ring cleavage of a wide range of hydroquinone substrates to produce the corresponding 4-hydroxymuconic semialdehydes.
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| History |
EC 1.13.11.66 created 2012
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| Pathway |
| Chlorocyclohexane and chlorobenzene degradation | | Microbial metabolism in diverse environments |
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| Orthology |
| hydroquinone 1,2-dioxygenase |
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| Genes |
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| Reference |
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| Authors |
Miyauchi K, Adachi Y, Nagata Y, Takagi M |
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| Title |
Cloning and sequencing of a novel meta-cleavage dioxygenase gene whose product is involved in degradation of gamma-hexachlorocyclohexane in Sphingomonas paucimobilis. |
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| Journal |
J. Bacteriol. 181 (1999) 6712-9. |
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| Sequence |
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| Reference |
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| Authors |
Moonen MJ, Synowsky SA, van den Berg WA, Westphal AH, Heck AJ, van den Heuvel RH, Fraaije MW, van Berkel WJ |
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| Title |
Hydroquinone dioxygenase from pseudomonas fluorescens ACB: a novel member of the family of nonheme-iron(II)-dependent dioxygenases. |
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| Journal |
J. Bacteriol. 190 (2008) 5199-209. |
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| Reference |
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| Authors |
Shen W, Liu W, Zhang J, Tao J, Deng H, Cao H, Cui Z |
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| Title |
Cloning and characterization of a gene cluster involved in the catabolism of p-nitrophenol from Pseudomonas putida DLL-E4. |
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| Journal |
Bioresour. Technol. 101 (2010) 7516-22. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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