KEGG ORTHOLOGY: K15245

ORTHOLOGY: K15245

Entry

K15245 KO

Name

tftC

Definition

chlorophenol-4-monooxygenase component 1 [EC:1.5.1.37]

Pathway

ko00361	Chlorocyclohexane and chlorobenzene degradation
ko00740	Riboflavin metabolism

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Metabolism of cofactors and vitamins
   00740 Riboflavin metabolism
    K15245  tftC; chlorophenol-4-monooxygenase component 1
  Xenobiotics biodegradation and metabolism
   00361 Chlorocyclohexane and chlorobenzene degradation
    K15245  tftC; chlorophenol-4-monooxygenase component 1
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.37  FAD reductase (NADH)
     K15245  tftC; chlorophenol-4-monooxygenase component 1

Other DBs

RN:

R05446 R05447 R05449 R09748

GO:

0018642

Genes

AG:	AAC23547(tftC)

Reference

PMID:19915006

Authors

Webb BN, Ballinger JW, Kim E, Belchik SM, Lam KS, Youn B, Nissen MS, Xun L, Kang C

Title

Characterization of chlorophenol 4-monooxygenase (TftD) and NADH:FAD oxidoreductase (TftC) of Burkholderia cepacia AC1100.

Journal

J Biol Chem 285:2014-27 (2010)
DOI:10.1074/jbc.M109.056135

Sequence

[ag:AAC23547]

LinkDB

ORTHOLOGY: K15246

Entry

K15246 KO

Name

tftD

Definition

chlorophenol-4-monooxygenase component 2 [EC:1.14.14.-]

Pathway

ko00361

Chlorocyclohexane and chlorobenzene degradation

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Xenobiotics biodegradation and metabolism
   00361 Chlorocyclohexane and chlorobenzene degradation
    K15246  tftD; chlorophenol-4-monooxygenase component 2
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.-
     K15246  tftD; chlorophenol-4-monooxygenase component 2

Other DBs

RN:

R05446 R05447 R05449

GO:

0018642

Genes

AG:	AAC23548(tftD)

Reference

PMID:19915006

Authors

Webb BN, Ballinger JW, Kim E, Belchik SM, Lam KS, Youn B, Nissen MS, Xun L, Kang C

Title

Characterization of chlorophenol 4-monooxygenase (TftD) and NADH:FAD oxidoreductase (TftC) of Burkholderia cepacia AC1100.

Journal

J Biol Chem 285:2014-27 (2010)
DOI:10.1074/jbc.M109.056135

LinkDB

ENZYME: 1.5.1.37

Entry

EC 1.5.1.37 Enzyme

Name

FAD reductase (NADH);
NADH-FAD reductase;
NADH-dependent FAD reductase;
NADH:FAD oxidoreductase;
NADH:flavin adenine dinucleotide oxidoreductase

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

FADH2:NAD+ oxidoreductase

Reaction(IUBMB)

FADH2 + NAD+ = FAD + NADH + H+ [RN:R09748]

Reaction(KEGG)

R09748

Substrate

FADH2 [CPD:C01352];
NAD+ [CPD:C00003]

Product

FAD [CPD:C00016];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme from Burkholderia phenoliruptrix can reduce either FAD or flavin mononucleotide (FMN) but prefers FAD. Unlike EC 1.5.1.36, flavin reductase (NADH), the enzyme can not reduce riboflavin. The enzyme does not use NADPH as acceptor.

History

EC 1.5.1.37 created 2011

Pathway