KEGG ORTHOLOGY: K16266

ORTHOLOGY: K16266

Entry

K16266 KO

Name

UGT85K

Definition

cyanohydrin UDP-glucosyltransferase [EC:2.4.1.-]

Pathway

ko00460

Cyanoamino acid metabolism

Brite

KEGG Orthology (KO) [BR:ko00001]
Metabolism
  Metabolism of other amino acids
   00460 Cyanoamino acid metabolism
    K16266  UGT85K; cyanohydrin UDP-glucosyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.-
     K16266  UGT85K; cyanohydrin UDP-glucosyltransferase

Other DBs

RN:

R03625 R10037

Genes

AG:	AEO45781(UGT85K4) AEO45782(UGT85K5)

Reference

PMID:21736650

Authors

Kannangara R, Motawia MS, Hansen NK, Paquette SM, Olsen CE, Moller BL, Jorgensen K

Title

Characterization and expression profile of two UDP-glucosyltransferases, UGT85K4 and UGT85K5, catalyzing the last step in cyanogenic glucoside biosynthesis in cassava.

Journal

Plant J 68:287-301 (2011)
DOI:10.1111/j.1365-313X.2011.04695.x

Sequence

[ag:AEO45781 AEO45782]

LinkDB

ENZYME: 2.4.1.63

Entry

EC 2.4.1.63 Enzyme

Name

linamarin synthase;
uridine diphosphoglucose-ketone glucosyltransferase;
uridine diphosphate-glucose-ketone cyanohydrin beta-glucosyltransferase;
UDP glucose ketone cyanohydrin glucosyltransferase;
UDP-glucose:ketone cyanohydrin beta-glucosyltransferase;
uridine diphosphoglucose-ketone cyanohydrin glucosyltransferase

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-glucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase

Reaction(IUBMB)

UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin [RN:R03625]

Reaction(KEGG)

R03625;
(other) R04948 R10037

Substrate

UDP-glucose [CPD:C00029];
2-hydroxy-2-methylpropanenitrile [CPD:C02659]

Product

UDP [CPD:C00015];
linamarin [CPD:C01594]

Comment

The enzyme glucosylates the cyanohydrins of butanone and pentan-3-one as well as that of acetone.

History

EC 2.4.1.63 created 1972

Pathway

ec00460	Cyanoamino acid metabolism
ec01110	Biosynthesis of secondary metabolites

Reference

1 [PMID:5417265]

Authors

Hahlbrock K, Conn EE.

Title

The biosynthesis of cyanogenic glycosides in higher plants. I. Purification and properties of a uridine diphosphate-glucose-ketone cyanohydrin beta-glucosyltransferase from Linum usitatissimum L.

Journal

J. Biol. Chem. 245 (1970) 917-22.

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.63

IUBMB Enzyme Nomenclature:

2.4.1.63

ExPASy - ENZYME nomenclature database:

2.4.1.63

BRENDA, the Enzyme Database:

2.4.1.63

CAS: