KEGG   ORTHOLOGY: K16305Help
Entry
K16305                      KO                                     

Name
K16305
Definition
fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase [EC:4.1.2.13 2.2.1.11]
Pathway
Glycolysis / Gluconeogenesis
Pentose phosphate pathway
Fructose and mannose metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
Methane metabolism
Carbon metabolism
Biosynthesis of amino acids
Module
M00001  
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01200 Carbon metabolism
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
   01230 Biosynthesis of amino acids
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
  Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
   00030 Pentose phosphate pathway
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
   00051 Fructose and mannose metabolism
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
  Energy metabolism
   00680 Methane metabolism
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
  Amino acid metabolism
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Central carbohydrate metabolism
    M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
     K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.2  Transferring aldehyde or ketonic groups
   2.2.1  Transketolases and transaldolases
    2.2.1.11  6-deoxy-5-ketofructose 1-phosphate synthase
     K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.13  fructose-bisphosphate aldolase
     K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
BRITE hierarchy
Other DBs
Genes
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MmarC7_1296
MMD: 
GYY_01500
MMAK: 
MMKA1_03000(fba)
MMAO: 
MMOS7_03270(fba)
MAE: 
Maeo_0690
MVN: 
Mevan_1304
MVO: 
Mvol_1341
MOK: 
Metok_1121
MAC: 
MA_2666 MA_3889
MBA: 
Mbar_A0176 Mbar_A2224
MBY: 
MSBRM_2208 MSBRM_2781
MBW: 
MSBRW_0821 MSBRW_2524
MBAR: 
MSBR2_0203 MSBR2_0204 MSBR2_2738
MBAK: 
MSBR3_2683
MMA: 
MM_0714
MMAZ: 
MmTuc01_0735
MMJ: 
MSMAS_0603
MMAC: 
MSMAC_0605
MVC: 
MSVAZ_0963
MEK: 
MSKOL_0932
MLS: 
MSLAZ_0625
METM: 
MSMTP_0658
MEF: 
MSWH1_0770
MEQ: 
MSWHS_0822
MSJ: 
MSSAC_1781 MSSAC_3626
MSZ: 
MSSIH_3164
MSW: 
MSSIT_3238
MTHE: 
MSTHC_0965
MTHR: 
MSTHT_2315
MHOR: 
MSHOH_0711
MPY: 
Mpsy_1203
MHZ: 
Metho_0427
MTP: 
Mthe_0380
MHI: 
Mhar_2267
MHU: 
Mhun_1466
MLA: 
Mlab_1135
MEM: 
Memar_1367
MBG: 
BN140_2246
MEMA: 
MMAB1_2969
MPI: 
Mpet_1339
MPL: 
Mpal_0799
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
White RH, Xu H
  Title
Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii.
  Journal
Biochemistry 45:12366-79 (2006)
DOI:10.1021/bi061018a
  Sequence
[mja:MJ_1585]
LinkDB All DBs

KEGG   ENZYME: 2.2.1.11Help
Entry
EC 2.2.1.11                 Enzyme                                 

Name
6-deoxy-5-ketofructose 1-phosphate synthase;
DKFP synthase
Class
Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases
BRITE hierarchy
Sysname
2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase
Reaction(IUBMB)
(1) 2-oxopropanal + D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [RN:R10049];
(2) 2-oxopropanal + D-fructose 1-phosphate = D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [RN:R10050]
Reaction(KEGG)
Substrate
2-oxopropanal [CPD:C00546];
D-fructose 1,6-bisphosphate [CPD:C00354];
D-fructose 1-phosphate [CPD:C01094]
Product
D-glyceraldehyde 3-phosphate [CPD:C00118];
1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [CPD:C16848];
D-glyceraldehyde [CPD:C00577]
Comment
The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.
History
EC 2.2.1.11 created 2012
Pathway
Phenylalanine, tyrosine and tryptophan biosynthesis
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
Orthology
K16305  
fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
Genes
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MmarC7_1296
MMD: 
GYY_01500
MMAK: 
MMKA1_03000(fba)
MMAO: 
MMOS7_03270(fba)
MAE: 
Maeo_0690
MVN: 
Mevan_1304
MVO: 
Mvol_1341
MOK: 
Metok_1121
MAC: 
MA_2666 MA_3889
MBA: 
Mbar_A0176 Mbar_A2224
MBY: 
MSBRM_2208 MSBRM_2781
MBW: 
MSBRW_0821 MSBRW_2524
MBAR: 
MSBR2_0203 MSBR2_0204 MSBR2_2738
MBAK: 
MSBR3_2683
MMA: 
MM_0714
MMAZ: 
MmTuc01_0735
MMJ: 
MSMAS_0603
MMAC: 
MSMAC_0605
MVC: 
MSVAZ_0963
MEK: 
MSKOL_0932
MLS: 
MSLAZ_0625
METM: 
MSMTP_0658
MEF: 
MSWH1_0770
MEQ: 
MSWHS_0822
MSJ: 
MSSAC_1781 MSSAC_3626
MSZ: 
MSSIH_3164
MSW: 
MSSIT_3238
MTHE: 
MSTHC_0965
MTHR: 
MSTHT_2315
MHOR: 
MSHOH_0711
MPY: 
Mpsy_1203
MHZ: 
Metho_0427
MTP: 
Mthe_0380
MHI: 
Mhar_2267
MHU: 
Mhun_1466
MLA: 
Mlab_1135
MEM: 
Memar_1367
MBG: 
BN140_2246
MEMA: 
MMAB1_2969
MPI: 
Mpet_1339
MPL: 
Mpal_0799
 » show all
Taxonomy
Reference
1  [PMID:17014089]
  Authors
White RH, Xu H
  Title
Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii.
  Journal
Biochemistry. 45 (2006) 12366-79.
  Sequence
[mja:MJ_1585]
Reference
2  [PMID:18318840]
  Authors
Samland AK, Wang M, Sprenger GA
  Title
MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity.
  Journal
FEMS. Microbiol. Lett. 281 (2008) 36-41.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
LinkDB All DBs

KEGG   REACTION: R10049Help
Entry
R10049                      Reaction                               

Name
2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase
Definition
Methylglyoxal + D-Fructose 1,6-bisphosphate <=> D-Glyceraldehyde 3-phosphate + 6-Deoxy-5-ketofructose 1-phosphate
Equation
Reaction class
C00118_C00354
C00546_C16848
C00354_C16848
Enzyme
Pathway
Phenylalanine, tyrosine and tryptophan biosynthesis
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
Orthology
K16305  
fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase [EC:4.1.2.13 2.2.1.11]
LinkDB All DBs

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