KEGG   ORTHOLOGY: K16306Help
Entry
K16306                      KO                                     

Name
K16306
Definition
fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase [EC:4.1.2.13 2.2.1.10]
Pathway
Glycolysis / Gluconeogenesis
Pentose phosphate pathway
Fructose and mannose metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
Methane metabolism
Carbon metabolism
Biosynthesis of amino acids
Module
M00001  
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01200 Carbon metabolism
    K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
   01230 Biosynthesis of amino acids
    K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
  Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
   00030 Pentose phosphate pathway
    K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
   00051 Fructose and mannose metabolism
    K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
  Energy metabolism
   00680 Methane metabolism
    K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
  Amino acid metabolism
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Central carbohydrate metabolism
    M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
     K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.2  Transferring aldehyde or ketonic groups
   2.2.1  Transketolases and transaldolases
    2.2.1.10  2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
     K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.13  fructose-bisphosphate aldolase
     K16306  K16306; fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
BRITE hierarchy
Other DBs
Genes
MRM: 
BMET: 
SRW: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMP0686
MMQ: 
MmarC5_0890
MMX: 
MmarC6_0201
MMZ: 
MmarC7_1710
MMD: 
GYY_02835
MMAK: 
MMKA1_07380
MMAO: 
MMOS7_07320
MAE: 
Maeo_0316
MVN: 
Mevan_1506
MVO: 
Mvol_0365
MOK: 
Metok_1495
MAC: 
MA_0439 MA_4591(deoC)
MBA: 
Mbar_A0753 Mbar_A0920
MBY: 
MSBRM_0075 MSBRM_0291
MBW: 
MSBRW_0078 MSBRW_0247
MBAR: 
MSBR2_2087 MSBR2_2305
MBAK: 
MSBR3_2087 MSBR3_2364
MMA: 
MM_1271 MM_1627
MMAZ: 
MmTuc01_1317 MmTuc01_1701
MMJ: 
MSMAS_0045 MSMAS_3044
MMAC: 
MSMAC_0045 MSMAC_1391
MVC: 
MSVAZ_0309 MSVAZ_3439
MEK: 
MSKOL_0292 MSKOL_3399
MLS: 
MSLAZ_0044 MSLAZ_0176
METM: 
MSMTP_0060 MSMTP_2943
MEF: 
MSWH1_0053 MSWH1_0299
MEQ: 
MSWHS_0056 MSWHS_0301
MSJ: 
MSSAC_0062 MSSAC_0390
MSZ: 
MSSIH_0055 MSSIH_0359
MSW: 
MSSIT_0055 MSSIT_0365
MTHE: 
MSTHC_1138 MSTHC_1506
MTHR: 
MSTHT_1780 MSTHT_2145
MHOR: 
MSHOH_0050 MSHOH_3760
MBU: 
Mbur_0917 Mbur_2001
MMET: 
MCMEM_0229 MCMEM_1419
MMH: 
Mmah_0241 Mmah_0691
MHAZ: 
BHR79_02305 BHR79_10150
MEV: 
Metev_1692 Metev_1714
MZH: 
Mzhil_0254 Mzhil_0268
MPY: 
Mpsy_1418 Mpsy_1446
MHZ: 
Metho_0254 Metho_0268
MTP: 
Mthe_0532 Mthe_0617
MCJ: 
MCON_1478 MCON_3321
MHI: 
Mhar_1906 Mhar_2111
MHU: 
Mhun_1035 Mhun_1036
MLA: 
Mlab_0600 Mlab_1654
MEM: 
Memar_1302 Memar_1303
MBG: 
BN140_2035(fbaA1) BN140_2036(fbaA3)
MEMA: 
MMAB1_2640 MMAB1_2641
MPI: 
Mpet_2705 Mpet_2706
MBN: 
Mboo_1557 Mboo_1558
MFO: 
Metfor_1589 Metfor_1590
MPL: 
Mpal_2610 Mpal_2611
MPD: 
MCP_1367 MCP_1669
MEZ: 
Mtc_1383(aroF) Mtc_1667
RCI: 
RRC153(aroF)
MTH: 
MTH_579
MMG: 
MTBMA_c09600(fbaB)
METC: 
MTCT_0503
MWO: 
MWSIV6_0939(aroA')
MST: 
Msp_0091
MSI: 
Msm_0056
MRU: 
mru_0997
MEB: 
Abm4_0656
MMIL: 
sm9_1016
MEYE: 
TL18_05340
MOL: 
YLM1_0540
MEL: 
Metbo_1361
MEW: 
MSWAN_0907
METH: 
MBMB1_1070
MFC: 
BRM9_1272
MFI: 
DSM1535_1956
MCUB: 
MCBB_0939(aroA')
MFV: 
Mfer_0600
MKA: 
MK1409(fbaB)
AFU: 
AF_0108
AFG: 
AFULGI_00001050
APO: 
Arcpr_0817
AVE: 
Arcve_1168
AST: 
Asulf_00941
FPL: 
Ferp_0600
GAC: 
GACE_1261
GAH: 
GAH_01502
HAL: 
VNG_0309C
HSL: 
OE_1472F(fba2)
HDL: 
HALDL1_05725
HHB: 
Hhub_1454
HJE: 
HacjB3_14310
HALH: 
HTSR_1439(fba2)
HHSR: 
HSR6_1511(fba2)
HMA: 
rrnAC1881(deoC2)
HHI: 
HAH_2396(fbaB2)
HHN: 
HISP_12200
HAB: 
SG26_04510
NPH: 
NP_3160A(fba2)
NMO: 
Nmlp_1197(fba2)
HUT: 
Huta_1178
HTI: 
HTIA_1098
HMU: 
Hmuk_3036
HALI: 
BV210_04645
HSU: 
HLASF_0623(fba1)
HSF: 
HLASA_0619(fba1)
HWA: 
HQ_1156A(fba2)
HWC: 
Hqrw_1193(fba2)
HVO: 
HVO_0790(fba2)
HME: 
HFX_0749(fbaB)
HGI: 
ABY42_03765
HBO: 
Hbor_24270
HLA: 
Hlac_1274
HTU: 
Htur_0853
HDA: 
BB347_01155
NMG: 
Nmag_2815
HXA: 
Halxa_4013
NAT: 
NJ7G_4134
NPE: 
Natpe_3297
NGE: 
Natgr_0761
HRU: 
Halru_2303
NOU: 
Natoc_0637
SALI: 
L593_00075
HLR: 
HALLA_07800
HLC: 
CHINAEXTREME00240
TAR: 
TALC_00560 TALC_00670
MAX: 
MMALV_05100
MER: 
MMINT_14400
MEAR: 
Mpt1_c09850(aroA'1) Mpt1_c10430(aroA'2)
MARC: 
AR505_0508
THB: 
N186_00460
TCB: 
TCARB_0208 TCARB_1172
THF: 
MA03_02210 MA03_05420
NMR: 
Nmar_0553
NIR: 
NSED_02805
NID: 
NPIRD3C_1721(aroA)
NIN: 
NADRNF5_1625(aroA)
NKR: 
NKOR_02865
NCT: 
NMSP_1118(aroA'_2)
CSY: 
CENSYa_0200
NGA: 
Ngar_c16210(aroGFH)
NVN: 
NVIE_005850(aroGFH)
NEV: 
NTE_01960
TAA: 
NMY3_02544(griI)
CSU: 
CSUB_C0867 CSUB_C0895
NBV: 
T478_0480
TAH: 
SU86_003320
NDV: 
NDEV_0554(aroA)
BARB: 
AOA66_0830(aroA')
LOKI: 
Lokiarch_06380(aroA'_1) Lokiarch_41970(aroA'_2)
HAH: 
Halar_3168
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Samland AK, Wang M, Sprenger GA
  Title
MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity.
  Journal
FEMS Microbiol Lett 281:36-41 (2008)
DOI:10.1111/j.1574-6968.2008.01079.x
  Sequence
[mja:MJ_0400]
Reference
  Authors
White RH
  Title
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.
  Journal
Biochemistry 43:7618-27 (2004)
DOI:10.1021/bi0495127
  Sequence
[mja:MJ_0400]
LinkDB All DBs

KEGG   ENZYME: 2.2.1.10Help
Entry
EC 2.2.1.10                 Enzyme                                 

Name
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase;
ADH synthase;
ADHS;
MJ0400 (gene name)
Class
Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases
BRITE hierarchy
Sysname
L-aspartate 4-semialdehyde:1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate methylglyoxaltransferase
Reaction(IUBMB)
L-aspartate 4-semialdehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate = 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + 2,3-dioxopropyl phosphate [RN:R08568]
Reaction(KEGG)
Substrate
L-aspartate 4-semialdehyde [CPD:C00441];
1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [CPD:C16848]
Product
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate;
2,3-dioxopropyl phosphate [CPD:C16849]
Comment
The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.
History
EC 2.2.1.10 created 2012
Pathway
Phenylalanine, tyrosine and tryptophan biosynthesis
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
Orthology
K16306  
fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
Genes
MRM: 
BMET: 
SRW: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMP0686
MMQ: 
MmarC5_0890
MMX: 
MmarC6_0201
MMZ: 
MmarC7_1710
MMD: 
GYY_02835
MMAK: 
MMKA1_07380
MMAO: 
MMOS7_07320
MAE: 
Maeo_0316
MVN: 
Mevan_1506
MVO: 
Mvol_0365
MOK: 
Metok_1495
MAC: 
MA_0439 MA_4591(deoC)
MBA: 
Mbar_A0753 Mbar_A0920
MBY: 
MSBRM_0075 MSBRM_0291
MBW: 
MSBRW_0078 MSBRW_0247
MBAR: 
MSBR2_2087 MSBR2_2305
MBAK: 
MSBR3_2087 MSBR3_2364
MMA: 
MM_1271 MM_1627
MMAZ: 
MmTuc01_1317 MmTuc01_1701
MMJ: 
MSMAS_0045 MSMAS_3044
MMAC: 
MSMAC_0045 MSMAC_1391
MVC: 
MSVAZ_0309 MSVAZ_3439
MEK: 
MSKOL_0292 MSKOL_3399
MLS: 
MSLAZ_0044 MSLAZ_0176
METM: 
MSMTP_0060 MSMTP_2943
MEF: 
MSWH1_0053 MSWH1_0299
MEQ: 
MSWHS_0056 MSWHS_0301
MSJ: 
MSSAC_0062 MSSAC_0390
MSZ: 
MSSIH_0055 MSSIH_0359
MSW: 
MSSIT_0055 MSSIT_0365
MTHE: 
MSTHC_1138 MSTHC_1506
MTHR: 
MSTHT_1780 MSTHT_2145
MHOR: 
MSHOH_0050 MSHOH_3760
MBU: 
Mbur_0917 Mbur_2001
MMET: 
MCMEM_0229 MCMEM_1419
MMH: 
Mmah_0241 Mmah_0691
MHAZ: 
BHR79_02305 BHR79_10150
MEV: 
Metev_1692 Metev_1714
MZH: 
Mzhil_0254 Mzhil_0268
MPY: 
Mpsy_1418 Mpsy_1446
MHZ: 
Metho_0254 Metho_0268
MTP: 
Mthe_0532 Mthe_0617
MCJ: 
MCON_1478 MCON_3321
MHI: 
Mhar_1906 Mhar_2111
MHU: 
Mhun_1035 Mhun_1036
MLA: 
Mlab_0600 Mlab_1654
MEM: 
Memar_1302 Memar_1303
MBG: 
BN140_2035(fbaA1) BN140_2036(fbaA3)
MEMA: 
MMAB1_2640 MMAB1_2641
MPI: 
Mpet_2705 Mpet_2706
MBN: 
Mboo_1557 Mboo_1558
MFO: 
Metfor_1589 Metfor_1590
MPL: 
Mpal_2610 Mpal_2611
MPD: 
MCP_1367 MCP_1669
MEZ: 
Mtc_1383(aroF) Mtc_1667
RCI: 
RRC153(aroF)
MTH: 
MTH_579
MMG: 
MTBMA_c09600(fbaB)
METC: 
MTCT_0503
MWO: 
MWSIV6_0939(aroA')
MST: 
Msp_0091
MSI: 
Msm_0056
MRU: 
mru_0997
MEB: 
Abm4_0656
MMIL: 
sm9_1016
MEYE: 
TL18_05340
MOL: 
YLM1_0540
MEL: 
Metbo_1361
MEW: 
MSWAN_0907
METH: 
MBMB1_1070
MFC: 
BRM9_1272
MFI: 
DSM1535_1956
MCUB: 
MCBB_0939(aroA')
MFV: 
Mfer_0600
MKA: 
MK1409(fbaB)
AFU: 
AF_0108
AFG: 
AFULGI_00001050
APO: 
Arcpr_0817
AVE: 
Arcve_1168
AST: 
Asulf_00941
FPL: 
Ferp_0600
GAC: 
GACE_1261
GAH: 
GAH_01502
HAL: 
VNG_0309C
HSL: 
OE_1472F(fba2)
HDL: 
HALDL1_05725
HHB: 
Hhub_1454
HJE: 
HacjB3_14310
HALH: 
HTSR_1439(fba2)
HHSR: 
HSR6_1511(fba2)
HMA: 
rrnAC1881(deoC2)
HHI: 
HAH_2396(fbaB2)
HHN: 
HISP_12200
HAB: 
SG26_04510
NPH: 
NP_3160A(fba2)
NMO: 
Nmlp_1197(fba2)
HUT: 
Huta_1178
HTI: 
HTIA_1098
HMU: 
Hmuk_3036
HALI: 
BV210_04645
HSU: 
HLASF_0623(fba1)
HSF: 
HLASA_0619(fba1)
HWA: 
HQ_1156A(fba2)
HWC: 
Hqrw_1193(fba2)
HVO: 
HVO_0790(fba2)
HME: 
HFX_0749(fbaB)
HGI: 
ABY42_03765
HBO: 
Hbor_24270
HLA: 
Hlac_1274
HTU: 
Htur_0853
HDA: 
BB347_01155
NMG: 
Nmag_2815
HXA: 
Halxa_4013
NAT: 
NJ7G_4134
NPE: 
Natpe_3297
NGE: 
Natgr_0761
HRU: 
Halru_2303
NOU: 
Natoc_0637
SALI: 
L593_00075
HLR: 
HALLA_07800
HLC: 
CHINAEXTREME00240
TAR: 
TALC_00560 TALC_00670
MAX: 
MMALV_05100
MER: 
MMINT_14400
MEAR: 
Mpt1_c09850(aroA'1) Mpt1_c10430(aroA'2)
MARC: 
AR505_0508
THB: 
N186_00460
TCB: 
TCARB_0208 TCARB_1172
THF: 
MA03_02210 MA03_05420
NMR: 
Nmar_0553
NIR: 
NSED_02805
NID: 
NPIRD3C_1721(aroA)
NIN: 
NADRNF5_1625(aroA)
NKR: 
NKOR_02865
NCT: 
NMSP_1118(aroA'_2)
CSY: 
CENSYa_0200
NGA: 
Ngar_c16210(aroGFH)
NVN: 
NVIE_005850(aroGFH)
NEV: 
NTE_01960
TAA: 
NMY3_02544(griI)
CSU: 
CSUB_C0867 CSUB_C0895
NBV: 
T478_0480
TAH: 
SU86_003320
NDV: 
NDEV_0554(aroA)
BARB: 
AOA66_0830(aroA')
LOKI: 
Lokiarch_06380(aroA'_1) Lokiarch_41970(aroA'_2)
HAH: 
Halar_3168
 » show all
Taxonomy
Reference
1  [PMID:15182204]
  Authors
White RH.
  Title
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.
  Journal
Biochemistry. 43 (2004) 7618-27.
  Sequence
[mja:MJ_0400]
Reference
2  [PMID:18318840]
  Authors
Samland AK, Wang M, Sprenger GA
  Title
MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity.
  Journal
FEMS. Microbiol. Lett. 281 (2008) 36-41.
  Sequence
[mja:MJ_0400]
Reference
3  [PMID:17713928]
  Authors
Morar M, White RH, Ealick SE.
  Title
Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
  Journal
Biochemistry. 46 (2007) 10562-71.
  Sequence
[mja:MJ_0400]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
LinkDB All DBs

KEGG   REACTION: R08568Help
Entry
R08568                      Reaction                               

Name
L-aspartate 4-semialdehyde:1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate methylglyoxaltransferase
Definition
L-Aspartate 4-semialdehyde + 6-Deoxy-5-ketofructose 1-phosphate <=> 2-Amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid + Hydroxypyruvaldehyde phosphate
Equation
Comment
possibly two-step reaction (aldehyde-lyase x2)
Reaction class
C00441_C16850
C16848_C16849
Enzyme
Pathway
Phenylalanine, tyrosine and tryptophan biosynthesis
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
Orthology
K16306  
fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase [EC:4.1.2.13 2.2.1.10]
Reference
1  [PMID:17713928]
Morar M, White RH, Ealick SE.
Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
Biochemistry. 46 (2007) 10562-71.
LinkDB All DBs

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