| Entry |
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| Name |
aminodeoxyfutalosine nucleosidase;
AFL nucleosidase;
aminofutalosine nucleosidase;
methylthioadenosine nucleosidase;
MqnB
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| Class |
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
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| Sysname |
6-amino-6-deoxyfutalosine ribohydrolase
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| Reaction(IUBMB) |
6-amino-6-deoxyfutalosine + H2O = dehypoxanthine futalosine + adenine [RN: R10668]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
dehypoxanthine futalosine [CPD: C17010];
adenine [CPD: C00147]
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| Comment |
The enzyme, found in several bacterial species, catalyses a step in a modified futalosine pathway for menaquinone biosynthesis. While the enzyme from some organisms also has the activity of EC 3.2.2.9, adenosylhomocysteine nucleosidase, the enzyme from Chlamydia trachomatis is specific for 6-amino-6-deoxyfutalosine [7].
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| History |
EC 3.2.2.30 created 2014
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| Pathway |
| Ubiquinone and other terpenoid-quinone biosynthesis | | Biosynthesis of secondary metabolites |
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| Orthology |
| adenosylhomocysteine/aminodeoxyfutalosine nucleosidase |
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| Genes |
FTU: | | FTQ: | | FTF: | | FTW: | | FTR: | | FTT: | | FTY: | | FTG: | | FTL: | | FTH: | | FTA: | | FTS: | | FTI: | | FTO: | | FTC: | | FTV: | | FTZ: | | FTM: | | FTN: | | FTX: | | FTD: | | FCF: | | FCN: | | FPH: | | FPT: | | FPI: | | FPM: | | FPX: | | FPZ: | | FPJ: | | FRT: | | FNA: | | FNL: | | FRF: | | FPER: | | FHI: | | HPY: | | HEO: | | HPJ: | | HPA: | | HPS: | | HHP: | | HHQ: | | HHR: | | HPG: | | HPP: | | HPB: | | HPL: | | HPC: | | HCA: | | HPM: | | HPE: | | HPO: | | HPI: | | HPQ: | | HPW: | | HPU: | | HEF: | | HPF: | | HEQ: | | HEX: | | HPT: | | HPZ: | | HPV: | | HPX: | | HEN: | | HPH: | | HEG: | | HPN: | | HEP: | | HEU: | | HES: | | HPYS: | | HCN: | | HPD: | | HEY: | | HER: | | HEI: | | HPYA: | | HPYK: | | HPYO: | | HPYL: | | HPYB: | | HPYC: | | HPYD: | | HPYE: | | HPYF: | | HPYG: | | HPYH: | | HPYJ: | | HPYR: | | HPYI: | | HPYU: | | HPYM: | | HEM: | | HEB: | | HEZ: | | HHE: | | HAC: | | HMS: | | HFE: | | HBI: | | HCE: | | HCM: | | HCP: | | HCB: | | HHM: | | HTY: | | HBL: | | WSU: | | TDN: | | SUA: | | SKU: | | SULR: | | CJE: | | CJB: | | CJJ: | | CJU: | | CJN: | | CJI: | | CJM: | | CJS: | | CJP: | | CJEJ: | | CJEU: | | CJEN: | | CJEI: | | CJER: | | CJV: | | CJY: | | CJQ: | | CJL: | | CJW: | | CJR: | | CJD: | | CJZ: | | CJX: | | CFF: | | CFT: | | CFV: | | CFX: | | CFZ: | | CAMP: | | CFP: | | CCV: | | CHA: | | CCO: | | CCOC: | | CLA: | | CLR: | | CLM: | | CLQ: | | CLN: | | CLL: | | CCOL: | | CCC: | | CCQ: | | CCF: | | CCY: | | CCOI: | | CCOF: | | CCOO: | | CAJ: | | CIS: | | CVO: | | CPEL: | | CAMR: | | CSM: | | CSF: | | CGRA: | | CURE: | | CHYO: | | CHV: | | ABU: | | ABT: | | ABL: | | ANT: | | ARC: | | ALP: | | SDL: | | SBA: | | SMUL: | | SHAL: | | SULS: | | NSA: | | NIS: | | SUN: | | SLH: | | NAM: | | VIR: | | STA: | |
» show all
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| Reference |
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| Authors |
Hiratsuka T, Furihata K, Ishikawa J, Yamashita H, Itoh N, Seto H, Dairi T |
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| Title |
An alternative menaquinone biosynthetic pathway operating in microorganisms. |
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| Journal |
Science. 321 (2008) 1670-3. |
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| Reference |
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| Authors |
Li X, Apel D, Gaynor EC, Tanner ME |
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| Title |
5'-methylthioadenosine nucleosidase is implicated in playing a key role in a modified futalosine pathway for menaquinone biosynthesis in Campylobacter jejuni. |
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| Journal |
J. Biol. Chem. 286 (2011) 19392-8. |
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| Sequence |
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| Reference |
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| Authors |
Arakawa C, Kuratsu M, Furihata K, Hiratsuka T, Itoh N, Seto H, Dairi T |
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| Title |
Diversity of the early step of the futalosine pathway. |
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| Journal |
Antimicrob. Agents. Chemother. 55 (2011) 913-6. |
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| Sequence |
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| Reference |
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| Authors |
Wang S, Haapalainen AM, Yan F, Du Q, Tyler PC, Evans GB, Rinaldo-Matthis A, Brown RL, Norris GE, Almo SC, Schramm VL |
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| Title |
A picomolar transition state analogue inhibitor of MTAN as a specific antibiotic for Helicobacter pylori. |
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| Journal |
Biochemistry. 51 (2012) 6892-4. |
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| Sequence |
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| Reference |
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| Authors |
Mishra V, Ronning DR |
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| Title |
Crystal structures of the Helicobacter pylori MTAN enzyme reveal specific interactions between S-adenosylhomocysteine and the 5'-alkylthio binding subsite. |
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| Journal |
Biochemistry. 51 (2012) 9763-72. |
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| Sequence |
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| Reference |
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| Authors |
Kim RQ, Offen WA, Davies GJ, Stubbs KA |
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| Title |
Structural enzymology of Helicobacter pylori methylthioadenosine nucleosidase in the futalosine pathway. |
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| Journal |
Acta. Crystallogr. D. Biol. Crystallogr. 70 (2014) 177-85. |
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| Sequence |
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| Reference |
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| Authors |
Barta ML, Thomas K, Yuan H, Lovell S, Battaile KP, Schramm VL, Hefty PS |
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| Title |
Structural and biochemical characterization of Chlamydia trachomatis hypothetical protein CT263 supports that menaquinone synthesis occurs through the futalosine pathway. |
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| Journal |
J. Biol. Chem. 289 (2014) 32214-29. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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