| Entry |
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| Name |
aminodeoxyfutalosine synthase;
MqnE;
AFL synthase;
aminofutalosine synthase;
S-adenosyl-L-methionine:3-[(1-carboxyvinyl)-oxy]benzoate adenosyltransferase (bicarbonate-hydrolysing, 6-amino-6-deoxyfutalosine-forming)
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
S-adenosyl-L-methionine:3-[(1-carboxyvinyl)-oxy]benzoate adenosyltransferase (HCO3--hydrolysing, 6-amino-6-deoxyfutalosine-forming)
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + 3-[(1-carboxyvinyl)oxy]benzoate + H2O = 6-amino-6-deoxyfutalosine + L-methionine + HCO3- [RN: R10667]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
3-[(1-carboxyvinyl)oxy]benzoate [CPD: C20772];
H2O [CPD: C00001]
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| Product |
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| Comment |
This enzyme is a member of the 'AdoMet radical' (radical SAM) family. S-Adenosyl-L-methionine acts as both a radical generator and as the source of the transferred adenosyl group. The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.
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| History |
EC 2.5.1.120 created 2014
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| Pathway |
| Ubiquinone and other terpenoid-quinone biosynthesis | | Biosynthesis of secondary metabolites |
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| Orthology |
| aminodeoxyfutalosine synthase |
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| Genes |
HPY: | | HEO: | | HPJ: | | HPA: | | HPS: | | HHP: | | HHQ: | | HHR: | | HPG: | | HPP: | | HPB: | | HPL: | | HPC: | | HCA: | | HPM: | | HPE: | | HPO: | | HPI: | | HPQ: | | HPW: | | HPU: | | HEF: | | HPF: | | HEQ: | | HEX: | | HPT: | | HPZ: | | HPV: | | HPX: | | HEN: | | HPH: | | HEG: | | HPN: | | HEP: | | HEU: | | HES: | | HPYS: | | HCN: | | HPD: | | HEY: | | HER: | | HEI: | | HPYA: | | HPYK: | | HPYO: | | HPYL: | | HPYB: | | HPYC: | | HPYD: | | HPYE: | | HPYF: | | HPYG: | | HPYH: | | HPYJ: | | HPYR: | | HPYI: | | HPYU: | | HPYM: | | HEM: | | HEB: | | HEZ: | | HHE: | | HAC: | | HMS: | | HFE: | | HBI: | | HCE: | | HCM: | | HCP: | | HCB: | | HHM: | | HTY: | | HBL: | | WSU: | | TDN: | | SUA: | | SKU: | | SULR: | | CJE: | | CJB: | | CJJ: | | CJU: | | CJN: | | CJI: | | CJM: | | CJS: | | CJP: | | CJEJ: | | CJEU: | | CJEN: | | CJEI: | | CJER: | | CJV: | | CJY: | | CJQ: | | CJL: | | CJW: | | CJR: | | CJD: | | CJZ: | | CJX: | | CFF: | | CFT: | | CFV: | | CFX: | | CFZ: | | CAMP: | | CFP: | | CCV: | | CHA: | | CCO: | | CCOC: | | CLA: | | CLR: | | CLM: | | CLQ: | | CLN: | | CLL: | | CCOL: | | CCC: | | CCQ: | | CCF: | | CCY: | | CCOI: | | CCOF: | | CCOO: | | CAJ: | | CIS: | | CVO: | | CPEL: | | CAMR: | | CSM: | | CSF: | | CGRA: | | CURE: | | CHYO: | | CHV: | | ABU: | | ABT: | | ABL: | | ANT: | | ARC: | | ALP: | | SDL: | | SBA: | | SMUL: | | SHAL: | | SULS: | | NSA: | | NIS: | | SUN: | | SLH: | | NAM: | | GSU: | | GSK: | | GME: | | GUR: | | GLO: | | GBM: | | GEO: | | GEM: | | GEB: | | GPI: | | GAO: | | GSB: | | PCA: | | PPD: | | PACE: | | PEF: | | DES: | | DEU: | | DVU: | | DVL: | | DVM: | | DVG: | | DDE: | | DDS: | | DDN: | | DMA: | | DSA: | | DAS: | | DAF: | | DHY: | | DPI: | | DGG: | | DFI: | | DPG: | | DBA: | | DOA: | | DRT: | | DAK: | | DPR: | | DSF: | | DOL: | | DML: | | DTO: | | ADE: | | ACP: | | AFW: | | ANK: | | VIN: | | LLU: | | DAO: | | SFU: | | DBR: | | HMR: | | DAV: | | BHA: | | BCL: | | BPF: | | BCO: | | BLE: | | FPN: | | FAR: | | BSE: | | BBE: | | BLR: | | PJD: | | GYM: | | PPY: | | PPM: | | PPO: | | PPOL: | | PPQ: | | PPOY: | | PMS: | | PMQ: | | PMW: | | PTA: | | PLV: | | PSAB: | | PDU: | | PBD: | | PGM: | | POD: | | PAEN: | | PAEF: | | PAEQ: | | PSTE: | | PAEA: | | PAEE: | | PAEH: | | PAEJ: | | PBJ: | | PIH: | | PRI: | | PPEO: | | PNP: | | POW: | | PBV: | | PXL: | | PYG: | | PSWU: | | TCO: | | ANX: | | BTS: | | TUM: | | STH: | | SWO: | | SLP: | | DRM: | | DAE: | | DCA: | | DKU: | | DRU: | | DGI: | | PTH: | | DAU: | | TJR: | | SGY: | | DOR: | | DAI: | | DMI: | | HMO: | | CHY: | | MTA: | | ADG: | | AAR: | | SSG: | | SRI: | | SELE: | | SELO: | | SELT: | | MHG: | | PUF: | | PFT: | | SCO: | | SMA: | | SGR: | | SGB: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SHO: | | SVE: | | SDV: | | SALB: | | SALS: | | STRP: | | SFI: | | SCI: | | SRC: | | SALU: | | SALL: | | SLV: | | SGU: | | SVT: | | STRE: | | SCW: | | SLD: | | SXI: | | STRM: | | STRC: | | SAMB: | | SPRI: | | SCZ: | | SCX: | | SRW: | | STRF: | | SLE: | | SRN: | | SPAV: | | SLC: | | STRT: | | SCLF: | | SGS: | | STSI: | | SLS: | | SNR: | | SPLU: | | STRD: | | SNW: | | KSK: | | FRA: | | FRE: | | FRI: | | FAL: | | FSY: | | ACE: | | STP: | | SAQ: | | MAU: | | MIL: | | VMA: | | AMS: | | ASE: | | ACTN: | | AFS: | | CAI: | | SNA: | | HAU: | | DRA: | | DGE: | | DDR: | | DMR: | | DPT: | | DGO: | | DPD: | | DSW: | | DCH: | | DAB: | | DPU: | | TRA: | | TTH: | | TTJ: | | TTS: | | TTL: | | TSC: | | THC: | | TOS: | | TAQ: | | TPAR: | | TBC: | | MRB: | | MRE: | | MSV: | | OPR: | | MHD: | | CCZ: | | FGI: | | XII: | | MIN: | | RBA: | | PSL: | | PIR: | | PLM: | | PBS: | | PLS: | | PLH: | | FMR: | | GES: | | IPA: | | SACI: | | PBOR: | | PHM: | | ACA: | | ACM: | | GMA: | | TRS: | | SUS: | | CTM: | | ABAC: | | FSU: | | FSC: | | GAU: | | GBA: | | BACC: | | AFD: | | RBC: | | BLQ: | | CPI: | | NKO: | | NSO: | | NIA: | | FLA: | | ARB: | | HHY: | | SGN: | | PHE: | | PEP: | | PCM: | | PSTY: | | PSN: | | SHG: | | SHT: | | SPHN: | | SCN: | | MUP: | | AAE: | | HYA: | | HHO: | | HYS: | | HTH: | | HTE: | | TAL: | | TRD: | | SUL: | | SAF: | | PMX: | | TTK: | | TAM: | | DTE: | | DIN: | | DDF: | | DAP: | | CNI: | | FSI: | | CABY: | | TYE: | | TID: | | TOP: | | TCM: | | CTHI: | | MOX: | | AFG: | | APO: | | AVE: | | AST: | | GAC: | | GAH: | | NMR: | | NIR: | | NID: | | NIN: | | NKR: | | NCT: | | CSY: | | TAA: | | NBV: | | TAH: | | NDV: | |
» show all
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| Reference |
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| Authors |
Mahanta N, Fedoseyenko D, Dairi T, Begley TP |
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| Title |
Menaquinone biosynthesis: formation of aminofutalosine requires a unique radical SAM enzyme. |
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| Journal |
J. Am. Chem. Soc. 135 (2013) 15318-21. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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