KEGG   ORTHOLOGY: K20979Help
Entry
K20979                      KO                                     

Name
GES
Definition
geranyl diphosphate diphosphatase [EC:3.1.7.11]
Pathway
Monoterpenoid biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of terpenoids and polyketides
   00902 Monoterpenoid biosynthesis
    K20979  GES; geranyl diphosphate diphosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.7  Diphosphoric-monoester hydrolases
    3.1.7.11  geranyl diphosphate diphosphatase
     K20979  GES; geranyl diphosphate diphosphatase
BRITE hierarchy
Other DBs
RN: 
Genes
CIT: 
TCC: 
GMX: 
PVU: 
VRA: 
VAR: 
CCAJ: 
MTR: 
CAM: 
ADU: 
AIP: 
107610456
LJA: 
Lj0g3v0315869.1(Lj0g3v0315869.1)
LANG: 
109351126
FVE: 
101307148
MDM: 
103417108
RCU: 
8287610(RcSeTPS11)
JCU: 
105631123 105631124 105639515
POP: 
POPTR_0007s02810g(POPTRDRAFT_763916)
VVI: 
100261928 100265373(GER)
SIND: 
105163844 105178600
EGU: 
105034750
MUS: 
103972569
ATR: 
18431529 18435272 18448640
AG: 
AAR11765(GES) CAD29734(GES)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Iijima Y, Gang DR, Fridman E, Lewinsohn E, Pichersky E
  Title
Characterization of geraniol synthase from the peltate glands of sweet basil.
  Journal
Plant Physiol 134:370-9 (2004)
DOI:10.1104/pp.103.032946
  Sequence
Reference
  Authors
Yang T, Li J, Wang HX, Zeng Y
  Title
A geraniol-synthase gene from Cinnamomum tenuipilum.
  Journal
Phytochemistry 66:285-93 (2005)
DOI:10.1016/j.phytochem.2004.12.004
  Sequence
LinkDB All DBs

KEGG   ENZYME: 3.1.7.3Help
Entry
EC 3.1.7.3                  Enzyme                                 

Name
monoterpenyl-diphosphatase;
bornyl pyrophosphate hydrolase;
monoterpenyl-pyrophosphatase
Class
Hydrolases;
Acting on ester bonds;
Diphosphoric-monoester hydrolases
BRITE hierarchy
Sysname
monoterpenyl-diphosphate diphosphohydrolase
Reaction(IUBMB)
a monoterpenyl diphosphate + H2O = a monoterpenol + diphosphate [RN:R03016]
Reaction(KEGG)
Substrate
monoterpenyl diphosphate [CPD:C03517];
H2O [CPD:C00001]
Product
monoterpenol [CPD:C00863];
diphosphate [CPD:C00013]
Comment
A group of enzymes with varying specificity for the monoterpenol moiety. One has the highest activity on sterically hindered compounds such as (+)-bornyl diphosphate; another has highest activity on the diphosphates of primary allylic alcohols such as geraniol.
History
EC 3.1.7.3 created 1984
Pathway
Monoterpenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
Reference
1  [PMID:42357]
  Authors
Croteau R, Karp F.
  Title
Biosynthesis of monoterpenes: hydrolysis of bornyl pyrophosphate, an essential step in camphor biosynthesis, and hydrolysis of geranyl pyrophosphate, the acyclic precursor of camphor, by enzymes from sage (Salvia officinalis).
  Journal
Arch. Biochem. Biophys. 198 (1979) 523-32.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
LinkDB All DBs

KEGG   ENZYME: 3.1.7.11Help
Entry
EC 3.1.7.11                 Enzyme                                 

Name
geranyl diphosphate diphosphatase;
geraniol synthase;
geranyl pyrophosphate pyrophosphatase;
GES;
CtGES
Class
Hydrolases;
Acting on ester bonds;
Diphosphoric-monoester hydrolases
BRITE hierarchy
Sysname
geranyl-diphosphate diphosphohydrolase
Reaction(IUBMB)
geranyl diphosphate + H2O = geraniol + diphosphate [RN:R08396]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341];
H2O [CPD:C00001]
Product
geraniol [CPD:C01500];
diphosphate [CPD:C00013]
Comment
Isolated from Ocimum basilicum (basil) and Cinnamomum tenuipile (camphor tree). Requires Mg2+ or Mn2+. Geraniol is labelled when formed in the presence of [18O]H2O. Thus mechanism involves a geranyl cation [1]. Neryl diphosphate is hydrolysed more slowly. May be the same as EC 3.1.7.3 monoterpenyl-diphosphatase.
History
EC 3.1.7.11 created 2012
Pathway
Monoterpenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
Orthology
K20979  
geranyl diphosphate diphosphatase
Genes
CIT: 
TCC: 
GMX: 
PVU: 
VRA: 
VAR: 
CCAJ: 
MTR: 
CAM: 
ADU: 
AIP: 
107610456
LJA: 
Lj0g3v0315869.1(Lj0g3v0315869.1)
LANG: 
109351126
FVE: 
101307148
MDM: 
103417108
RCU: 
8287610(RcSeTPS11)
JCU: 
105631123 105631124 105639515
POP: 
POPTR_0007s02810g(POPTRDRAFT_763916)
VVI: 
100261928 100265373(GER)
SIND: 
105163844 105178600
EGU: 
105034750
MUS: 
103972569
ATR: 
18431529 18435272 18448640
 » show all
Taxonomy
Reference
1  [PMID:14657409]
  Authors
Iijima Y, Gang DR, Fridman E, Lewinsohn E, Pichersky E
  Title
Characterization of geraniol synthase from the peltate glands of sweet basil.
  Journal
Plant. Physiol. 134 (2004) 370-9.
  Sequence
Reference
2  [PMID:15680985]
  Authors
Yang T, Li J, Wang HX, Zeng Y
  Title
A geraniol-synthase gene from Cinnamomum tenuipilum.
  Journal
Phytochemistry. 66 (2005) 285-93.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
LinkDB All DBs

KEGG   REACTION: R08396Help
Entry
R08396                      Reaction                               

Name
geranyl-diphosphate diphosphohydrolase
Definition
Geranyl diphosphate + H2O <=> Geraniol + Diphosphate
Equation
Reaction class
C00341_C01500
Enzyme
3.1.7.3         3.1.7.11
Pathway
Monoterpenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
Orthology
K20979  
geranyl diphosphate diphosphatase [EC:3.1.7.11]
LinkDB All DBs

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