KEGG   ORTHOLOGY: K20986Help
Entry
K20986                      KO                                     

Name
NUDX1
Definition
geranyl diphosphate phosphohydrolase [EC:3.6.1.68]
Pathway
Monoterpenoid biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Metabolism of terpenoids and polyketides
   00902 Monoterpenoid biosynthesis
    K20986  NUDX1; geranyl diphosphate phosphohydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.1  In phosphorus-containing anhydrides
    3.6.1.68  geranyl diphosphate phosphohydrolase
     K20986  NUDX1; geranyl diphosphate phosphohydrolase
BRITE hierarchy
Other DBs
RN: 
Genes
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
AG: 
AFW17224(NUDX1)
TaxonomyKoalaUniProt
Reference
  Authors
Magnard JL, Roccia A, Caissard JC, Vergne P, Sun P, Hecquet R, Dubois A, Hibrand-Saint Oyant L, Jullien F, Nicole F, Raymond O, Huguet S, Baltenweck R, Meyer S, Claudel P, Jeauffre J, Rohmer M, Foucher F, Hugueney P, Bendahmane M, Baudino S
  Title
PLANT VOLATILES. Biosynthesis of monoterpene scent compounds in roses.
  Journal
Science 349:81-3 (2015)
DOI:10.1126/science.aab0696
  Sequence
LinkDB All DBs

KEGG   ENZYME: 3.1.7.11Help
Entry
EC 3.1.7.11                 Enzyme                                 

Name
geranyl diphosphate diphosphatase;
geraniol synthase;
geranyl pyrophosphate pyrophosphatase;
GES;
CtGES
Class
Hydrolases;
Acting on ester bonds;
Diphosphoric-monoester hydrolases
BRITE hierarchy
Sysname
geranyl-diphosphate diphosphohydrolase
Reaction(IUBMB)
geranyl diphosphate + H2O = geraniol + diphosphate [RN:R08396]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341];
H2O [CPD:C00001]
Product
geraniol [CPD:C01500];
diphosphate [CPD:C00013]
Comment
Isolated from Ocimum basilicum (basil) and Cinnamomum tenuipile (camphor tree). Requires Mg2+ or Mn2+. Geraniol is labelled when formed in the presence of [18O]H2O. Thus mechanism involves a geranyl cation [1]. Neryl diphosphate is hydrolysed more slowly. May be the same as EC 3.1.7.3 monoterpenyl-diphosphatase.
History
EC 3.1.7.11 created 2012
Pathway
Monoterpenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
Orthology
K20979  
geranyl diphosphate diphosphatase
Genes
CIT: 
TCC: 
GMX: 
PVU: 
VRA: 
VAR: 
CCAJ: 
MTR: 
CAM: 
ADU: 
AIP: 
107610456
LJA: 
Lj0g3v0315869.1(Lj0g3v0315869.1)
LANG: 
109351126
FVE: 
101307148
MDM: 
103417108
RCU: 
8287610(RcSeTPS11)
JCU: 
105631123 105631124 105639515
POP: 
POPTR_0007s02810g(POPTRDRAFT_763916)
VVI: 
100261928 100265373(GER)
SIND: 
105163844 105178600
EGU: 
105034750
MUS: 
103972569
ATR: 
18431529 18435272 18448640
 » show all
Taxonomy
Reference
1  [PMID:14657409]
  Authors
Iijima Y, Gang DR, Fridman E, Lewinsohn E, Pichersky E
  Title
Characterization of geraniol synthase from the peltate glands of sweet basil.
  Journal
Plant. Physiol. 134 (2004) 370-9.
  Sequence
Reference
2  [PMID:15680985]
  Authors
Yang T, Li J, Wang HX, Zeng Y
  Title
A geraniol-synthase gene from Cinnamomum tenuipilum.
  Journal
Phytochemistry. 66 (2005) 285-93.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
LinkDB All DBs

KEGG   REACTION: R11551Help
Entry
R11551                      Reaction                               

Name
geranyl-diphosphate phosphohydrolase
Definition
Geranyl diphosphate + H2O <=> Geranyl phosphate + Orthophosphate
Equation
Reaction class
C00341_C21203
Enzyme
Pathway
Monoterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K20986  
geranyl diphosphate phosphohydrolase [EC:3.6.1.68]
LinkDB All DBs

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