Amycolatopsis mediterranei RB: B737_5113
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Entry
B737_5113 CDS
T02804
Symbol
metH
Name
(GenBank) 5-methyltetrahydrofolate--homocysteine methyltransferase
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
amz
Amycolatopsis mediterranei RB
Pathway
amz00270
Cysteine and methionine metabolism
amz00450
Selenocompound metabolism
amz00670
One carbon pool by folate
amz01100
Metabolic pathways
amz01110
Biosynthesis of secondary metabolites
amz01230
Biosynthesis of amino acids
amz04980
Cobalamin transport and metabolism
Module
amz_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
amz00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
B737_5113 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
B737_5113 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
B737_5113 (metH)
09150 Organismal Systems
09154 Digestive system
04980 Cobalamin transport and metabolism
B737_5113 (metH)
Enzymes [BR:
amz01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
B737_5113 (metH)
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Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
AGT85777
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Position
complement(5745822..5749451)
Genome browser
AA seq
1209 aa
AA seq
DB search
MNTPSESEARLRELLDQRVAVLDGAWGTMLQGAGLTPADYRGDRFGDHFHDVTGDPDLLN
LTRPDVILDVHRQYLAAGADITTTNTFTATSIGQADYGLQAYVHEMNVRGAQLARQAADE
AGGKFVAGSIGPLNVTLSLSPKVDDPAYRAVTFEQVKASYAEQIAGLAEGGVDLLLIETI
FDTLNCKAAIAAAREVAPQLPLWISVTIVDLSGRTLSGQTVEAFWSSIEHAKPLVVGVNC
SLGAEEMRPHVEELSRIAGTYVACHPNAGLPNAFGGYDQTPEETAGLIGGFARDGLVNLV
GGCCGTTPAHIAKIAAAAKEAGPREVPAPRTHMRFSGLEPFGIGADTGFVMIGERTNVTG
SKRFRRLIESGDHQGAVDVALEQVRGGANLLDVNMDADLLESEQAMTTFLNLIATEPEVA
RIPVMVDSSKWSVLEAGLRCLQGKGVVNSISLKEGEEPFLAQARTIRNYGAGVVVMAFDE
QGQADTADRKVAICGRAYDLLTQKAGFAGEDIIFDPNVLAVATGISEHNGYAKAFIEALP
RIKERCPGARTSGGISNLSFSFRGNDVVREAMHSAFLFHAVQAGLDMGIVNAGQLAVYED
IPKDLLELVEDVLFDRREDATDRLVSFAENVKGSGTKRVVDLSWREGTVGERLSHALVHG
IVDYIEDDTEEARQQLARPLDVIEGPLMDGMKIVGDLFGSGKMFLPQVVKSARVMKRSVA
YLEPYMEAEKEKARQEGRLASTGGQGKIVLATVKGDVHDIGKNIVGVVLGCNNYEVIDLG
VMVPAAKILDTAVTEGADAVGLSGLITPSLDEMVAVATEMQRRGLKLPLLIGGATTSRQH
TAVKIAPAYDNVTVHVLDASRVVGVVSDLLDADRSIALAEKNRADQEVLREQHASKQRRP
MLTLEQARANPEKVAFDGLPTPEFTGVRVLEPSIAELREMVDWQFLFLAWELKGKYPAIL
QQPVARELFDDANTLLDQIIADGSFTAKGAYAFWPAHREGDDILLDGEFAHVKFPMLRQQ
TAKPADRANRCLADYIAPVGDHLGGFAVAIHGAEALAKRFEAEQDDYRAIMVKALADRLA
EAFAEHIHLRARRDWFEPDAQPKLEDLHAERFRGIRPALGYPASPDHSQKRELFELLEAD
ELGMALTESYAMTPAASVSGLIFAHPDSRYFTVGRLGRDQVEDYARRKGVEIAEVEQWLR
PNLAYDPEA
NT seq
3630 nt
NT seq
+upstream
nt +downstream
nt
gtgaacaccccatccgagtccgaagcacgcttgcgtgagctgctcgaccagcgcgtggcg
gtcctggacggcgcctggggcaccatgttgcagggcgccgggctgaccccggccgactac
cgcggcgaccgcttcggcgaccacttccacgacgtcaccggcgaccccgacctgctgaac
ctcacccgcccggacgtcatcctcgacgtccaccgccagtacctggccgcgggcgcggac
atcaccacgaccaacacgttcaccgcgaccagcatcggccaggccgactacggcctgcag
gcctacgtccacgagatgaacgtccgcggcgcgcagctggcccgccaagccgccgacgaa
gcgggcggcaagttcgtcgccgggtcgatcggcccgctcaacgtcaccctcagcctgtcg
ccgaaggtcgatgacccggcgtaccgggcggtcacgttcgagcaggtcaaggcgtcctac
gccgagcagatcgccgggctcgccgaaggtggcgtcgacctgctgctgatcgagacgatc
ttcgacacgctgaactgcaaggccgcgatcgccgccgcgcgcgaggtcgcgccgcagctg
ccgctgtggatctcggtgacgatcgtcgacctgagcggccggacgctgtcggggcagacc
gtcgaggcgttctggagctcgatcgagcacgcgaagccgctggtcgtcggcgtgaactgc
tcgctcggcgccgaagagatgcgcccgcacgtcgaggagctctcgcggatcgccggcacc
tacgtggcctgccaccccaatgccggcctgccgaacgcgttcggcggctacgaccagacg
cccgaggagaccgctgggctgatcggcgggttcgcccgcgacggcctggtcaacctggtc
ggcggctgttgcggcaccaccccggcgcacatcgcgaagatcgccgcggcggcgaaggag
gccggcccgcgggaggtgccggcgccccgcacgcacatgcgcttcagcggcctggagccg
ttcggcatcggcgccgacacgggattcgtgatgatcggcgagcgcaccaacgtcaccggc
tccaagcggttccggcggctcatcgaatccggcgaccaccagggcgccgtcgacgtcgcg
ctggagcaggtccgcggcggggccaacctgctcgacgtcaacatggacgccgacctgctc
gaatccgagcaggcgatgacgacgttcctcaacctgatcgccaccgagcccgaggtggcc
cggatcccggtgatggtcgacagctccaagtggagcgtgctcgaagccgggctgcgctgc
ctgcagggcaaaggcgtggtcaactcgatcagcctcaaggagggcgaagagccgttcctc
gcccaggcccgcacgatccggaactacggcgccggcgtcgtcgtgatggcgttcgacgaa
cagggccaggccgacaccgccgaccgcaaggtggcgatctgcggccgcgcgtacgacctg
ctgacgcagaaggcgggcttcgcgggcgaggacatcatcttcgacccgaacgtcctcgcc
gtcgccaccggcatctccgagcacaacggctacgcgaaggccttcatcgaggcgctgccc
cggatcaaggagcgctgccccggcgcgcggaccagcggcggcatctcgaacctgtcgttc
tccttccgcggcaacgacgtggtgcgcgaggcgatgcactcggcgttcctgttccacgcc
gtgcaggccgggctggacatgggcatcgtcaacgccggccagctcgccgtctacgaagac
atcccgaaggacctcctcgagctggtcgaggacgtgctcttcgaccggcgcgaagacgcc
accgaccggctggtgagcttcgcggagaacgtcaagggcagcggcaccaagcgcgtcgtc
gacctctcctggcgcgaaggcacggtcggcgaacggctgtcccacgcgctggtgcacggg
atcgtcgactacatcgaggacgacaccgaagaggcgcggcagcagctggcgcggcccctc
gacgtcatcgagggtccgctgatggacggcatgaagatcgtcggcgacctgttcggctcc
ggcaagatgttcctgccgcaggtggtcaagagcgcgcgcgtgatgaagcggtccgtcgcc
tacctcgagccgtacatggaggcggagaaggagaaggcgcgccaggaggggcgcctggcc
tccaccggcggccagggcaagatcgtgctcgccacggtcaagggcgacgtccacgacatc
ggcaagaacatcgtcggcgtcgtgctcggctgcaacaactacgaggtgatcgacctcggc
gtgatggtgccggcggccaagatcctcgacaccgcggtgaccgaaggcgccgacgcggtc
gggctgtccggcctgatcacgccgtcgctggacgagatggtcgcggtcgccaccgagatg
cagcggcgcgggctgaaactgccgctgctcatcggcggcgcgacgacgtcccgccagcac
acggcggtcaagatcgccccggcctacgacaacgtcacggtgcacgtgctcgacgcgtcg
cgcgtggtcggcgtcgtgtccgacctgctcgacgcggaccgctcgatcgcgctggcggaa
aagaaccgagccgaccaggaggtgctgcgcgagcagcacgcgagcaagcagcgccgcccg
atgctcaccctcgagcaggcccgcgcgaaccccgagaaggtcgcgttcgacggcctgccg
acgccggagttcaccggcgtccgcgtgctcgagccgagcatcgcggaactgcgcgagatg
gtcgactggcagttcctgttcctggcctgggagctcaagggcaagtacccggccatcctg
cagcagccggtcgcccgcgagctgttcgacgacgcgaacaccctgctcgaccagatcatc
gccgacggcagcttcaccgcgaagggcgcgtacgcgttctggccggcgcaccgcgaaggc
gacgacatcctgctcgacggcgagttcgcgcacgtcaagttcccgatgctgcggcagcag
acggcgaagcccgccgaccgcgcgaaccgctgcctggccgactacatcgccccggtcggc
gaccacctcggcggcttcgcggtggccatccacggcgccgaggcgctggcgaagcggttc
gaagccgagcaggacgactaccgcgcgatcatggtcaaggcgctggccgaccggctcgcc
gaggcgttcgccgagcacatccacctgcgggcccgccgcgactggttcgagccggacgcg
cagccgaagctggaagacctgcacgcggagcgcttccgcggcatccgcccggcgctcggc
tacccggccagccccgaccacagccagaagcgcgagctgttcgagctcctggaagcggac
gagctgggcatggccctgaccgagtcgtacgcgatgacgccggcggcgagtgtgtccggg
ctgatcttcgcccacccggactcccgctacttcaccgtcggccggctcggccgcgaccag
gtcgaggactacgcccgccgcaagggcgtcgagatcgccgaggtcgagcagtggctgcgg
ccgaacctggcctacgaccccgaggcgtag
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