Canis lupus familiaris (dog): 489690
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Entry
489690 CDS
T01007
Symbol
HSD17B2
Name
(RefSeq) 17-beta-hydroxysteroid dehydrogenase type 2 isoform X2
KO
K13368
17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:
1.1.1.62
1.1.1.239
]
Organism
cfa
Canis lupus familiaris (dog)
Pathway
cfa00140
Steroid hormone biosynthesis
cfa01100
Metabolic pathways
cfa04913
Ovarian steroidogenesis
Module
cfa_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
cfa00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
489690 (HSD17B2)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
489690 (HSD17B2)
Enzymes [BR:
cfa01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.62 17beta-estradiol 17-dehydrogenase
489690 (HSD17B2)
1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
489690 (HSD17B2)
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Gene cluster
GFIT
Motif
Pfam:
adh_short
adh_short_C2
KR
DUF1776
Epimerase
IcmF-related
Motif
Other DBs
NCBI-GeneID:
489690
NCBI-ProteinID:
XP_005620709
Ensembl:
ENSCAFG00000019977
VGNC:
41805
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Position
5:complement(69936380..70023461)
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AA seq
443 aa
AA seq
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MTHQEICACMSVLNPRSFEVGRCCFLPLPPRLSVHITGLPPDSLCPLASPVLSTQRCSTS
LRMSTFSETVWLCLAVTVVLGGLALGNLRKIPGQMRRKVVCLAGLWGGAYLLFSLSLSWG
LILFFLSCVLTYTYLSGQELLPVDQKAVLITGGDSGFGHALSKYLDELGFTVFVGVLDEK
GSGAEELRRTCSKRLSVLQMDITDQQQIKDAHSKVVEKLQDRGLWAVVNNAGIICLPADG
ELIPMTDYKKCMAVNFFGAVEVTKAFLPLLRKSKGRLVNISSMAGVPMEKLAAYSSSKAA
LTMFSAVMRQELSKWGVKVSVIQPGGFRTNIAGTSEMWSKLEKNILDHLSSDVEEDYGKD
YILQQRNYLKSINIKTNTDISPVLQDIRHAVSAKSPFAFYAPGALAYCLLFFVSFSPTGI
FDYFSKKLCEVRGSMPRALIKQP
NT seq
1332 nt
NT seq
+upstream
nt +downstream
nt
atgacccatcaggaaatatgtgcttgtatgagtgtgcttaatccacgctcatttgaagtg
ggccggtgctgctttctccccctccctcctcgtctctctgttcatataaccgggctgcct
ccagacagcctttgcccacttgcctcgccggtcctgagcacacaaaggtgcagcacgtct
ctgagaatgagtaccttctcggagacggtgtggctctgcctggctgtcaccgtagtgctg
ggaggactagctcttggcaatctcagaaagatcccagggcagatgaggagaaaggtggtc
tgcctggcgggcctctggggaggggcttacctgctgttcagcctgtccctctcctggggc
ttgatcctcttcttcctgtcctgtgtcctcacctacacttacttgtctggtcaagagttg
ttacctgtggatcaaaaggcggtgctcatcacaggtggcgattccggatttggtcatgct
ctatctaaatatctagatgagcttggcttcacggtatttgtgggagttctggatgaaaag
ggatcaggagcagaggaattgcgaagaacctgctccaagcgcctctctgtgctccagatg
gacatcaccgaccagcaacagataaaagacgcccacagcaaagtggtggaaaagttgcag
gacagaggattgtgggctgtggtcaacaatgctgggatcatttgcttaccagccgacgga
gagctcattcccatgactgactacaaaaaatgcatggctgtgaacttcttcggggctgtg
gaggtcacaaaggcatttttgcctcttcttaggaaatcgaagggcaggctggtaaacatc
agcagcatggcaggggtcccaatggaaaagctggcagcctatagctcatccaaggcggct
ctgaccatgttttcagcagtcatgagacaagagctttccaaatggggagttaaagtctct
gtcatccagcctggaggcttcagaacaaatatcgcaggcacaagtgaaatgtggagtaag
ctggaaaagaacatcctggaccaccttagctctgacgtggaggaggactatggcaaggat
tatatcctccagcagcggaattatctgaagtcaatcaatataaaaaccaacacggatata
tcccctgtgctccaggacatccgacatgccgtgtctgctaagagcccctttgccttttat
gcaccgggggcattggcttattgtttgctcttttttgtttcctttagtcctactggcata
tttgattattttagcaaaaaattgtgtgaagttagagggagtatgcccagagcactcatt
aagcagccctaa
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