Canis lupus familiaris (dog): 490425 Help Entry 490425            CDS       T01007                                  Symbol PKLR Name (RefSeq) pyruvate kinase PKLR isoform 1   KO K12406   pyruvate kinase isozymes R/L [EC:2.7.1.40] Organism cfa  Canis lupus familiaris (dog) Pathway cfa00010   Glycolysis / Gluconeogenesis cfa00620   Pyruvate metabolism cfa01100   Metabolic pathways cfa01200   Carbon metabolism cfa01230   Biosynthesis of amino acids cfa04910   Insulin signaling pathway cfa04930   Type II diabetes mellitus cfa04932   Non-alcoholic fatty liver disease cfa04950   Maturity onset diabetes of the young Module cfa_M00001   Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate cfa_M00002   Glycolysis, core module involving three-carbon compounds Brite KEGG Orthology (KO) [BR:cfa00001]  09100 Metabolism   09101 Carbohydrate metabolism    00010 Glycolysis / Gluconeogenesis     490425 (PKLR)    00620 Pyruvate metabolism     490425 (PKLR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     490425 (PKLR)  09160 Human Diseases   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     490425 (PKLR)    04950 Maturity onset diabetes of the young     490425 (PKLR)    04932 Non-alcoholic fatty liver disease     490425 (PKLR)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:cfa04147]     490425 (PKLR) Enzymes [BR:cfa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.40  pyruvate kinase      490425 (PKLR) Exosome [BR:cfa04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    490425 (PKLR) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK PK_C IMPDH HpcH_HpaI Motif Other DBs NCBI-GeneID:  490425 NCBI-ProteinID:  NP_001243191 Ensembl:  ENSCAFG00000016959 VGNC:  44609 UniProt:  Q29536 LinkDB All DBs Position 7:41754768..41762716 Genome browser AA seq 574 aa AA seqDB search MSSQENIQPQELWSRISKSQRDLAKSILIGAPGGPAGYLRRASVAQLTLELGTAFFQQQQ LSAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASHSVERLKEMIKAGMNIARLNFS HGSHEYHAQSIANIREAVESFATSPLGYRPVAIALDTKGPEIRTGVLKGGPETEVELVKG SWVLVTVDPAFRTLGDAHTVWVDYPNIVKVVPVGGRIFIDDGLISLQVKKIDRKGLETQV ENGGLLGSRKGVNLPGAEVDLPGLSEQDAQDLRFGVEHNVDIVFASFVRKASDVAAIRAA LGPEGRTIKIISKIENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRC NLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGKFPVEAVKM QHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTKTGRS AQLLSRYRPRAAVIAVTRSAQAARQAHLCRGVFPLLYSEPPEAIWADDVDRRVQFGIESG KLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS NT seq 1725 nt NT seq  +upstreamnt  +downstreamnt atgtccagtcaggagaacatacaaccccaggagctttggtcaaggatctctaagtcccaa agggacttagcaaagtccatcttgattggggctccaggaggaccggcgggctacctgagg cgggccagtgtggcccagctgaccctagagctgggcaccgccttcttccagcagcagcag ctgtcagctgctatggcagacaccttcctggagcacctgtgcctgctggacatcgactcg gagcctgtggccgcccgcagtaccagcatcattgccaccatcgggccagcctctcattcg gtggagcgcctcaaggagatgatcaaggccgggatgaacattgcgcgcctcaacttctcc cacggctcccatgagtaccatgctcagtccatcgccaacatccgggaggccgtggagagc tttgcaacttctccgctcggctatcgccccgtggccattgccctggacaccaagggaccg gagatacggaccggggtcctgaaggggggccctgagaccgaagtggagctagtgaagggc tcctgggtcctggtgaccgtggacccggcgttccggacgctgggggacgcacacaccgtg tgggtggactatcccaatatcgtcaaggtcgtgccggtgggaggccgcatcttcatagac gacgggctcatctccctgcaggtcaagaaaatagaccggaaggggctggagacccaagtg gagaatggaggtctcctgggcagccggaaaggcgtaaacctgccaggcgccgaggtggac ttgccggggctgtctgagcaagacgcccaggacctacgcttcggggtggagcataatgtg gacatcgtctttgcctcctttgtgaggaaagccagtgatgtggctgccatccgggctgct ctggggccggaaggacggaccatcaagatcattagcaaaattgagaaccacgaaggcgtg aagaagtttgatgaaatcctggaggtgagtgacggcatcatggtggcacggggcgaccta ggcatcgagatccctgctgagaaggttttcctggcccagaagatgatgattggtcggtgc aacttggcgggcaagcctgtcgtctgtgccacacagatgctggagagcatgatcactaag ccccggccaacccgggcagagacgagtgatgtagccaatgctgtgctggatggagcagat tgcatcatgctatcaggggagaccgccaagggcaaatttcctgtggaggctgtaaagatg cagcatgcgattgccagggaggcagaggctgctgtgtaccaccggcagctgtttgaggaa ctgcgccgggcagcgccactgagccgcgatcccacggaggtcactgccataggcgcggtg gaggccgccttcaagtgctgtgctgctgccatcatcgtgctgaccaagaccggccgttca gcacagctgctatctcggtaccggcctcgggcagcggtcattgctgtcacccgctctgcc caggctgcccggcaggcccacctgtgccgaggggtcttccccttgctctacagtgaacct ccagaggccatctgggcagacgatgtggatcgccgggtccaatttggcattgaaagtgga aagctccgtggcttcctccgtgtgggggacctggtgattgtggtgacaggctggcgacct ggctctggctataccaacatcatgcgagtgctcagcatatcctga

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