KEGG   DGROUP: ImatinibHelp
Entry
DG00710           Chemical  DGroup                                 

Name
Imatinib
Member
D08066  
Imatinib (INN)
D01441  
Imatinib mesylate (USAN); Imatinib mesilate (JAN)  <JP/US>
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
Cyp substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
 DG01522  CYP3A4 inhibitor
Transporter substrate
 DG01665  P-glycoprotein substrate
 DG01913  BCRP substrate
Remark
ATC code: 
Comment
Antineoplastics
Target
BCR-ABL [HSA:25] [KO:K06619]
PDGFRA [HSA:5156] [KO:K04363]
PDGFRB [HSA:5159] [KO:K05089]
KIT (CD117) [HSA:3815] [KO:K05091]
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP2D6 [HSA:1565], CYP2C9 [HSA:1559]
Transporter: ABCB1 [HSA:5243], ABCG2 [HSA:9429]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551], CYP2D6 [HSA:1565]
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