| Entry |
|
|---|
| Name |
Dihydrocodeine phosphate (JP18);
Dihydro (TN) |
|---|
| Formula |
C18H23NO3. H3PO4
|
|---|
| Exact mass |
399.1447
|
|---|
| Mol weight |
399.3753
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
|
|---|
| Remark |
| Product (DG00814): | D01481<JP> |
| Product (mixture): | D04313<JP> D04338<JP> D08695<JP> D08697<JP> |
|
|---|
| Efficacy |
Antitussive, Narcotic, Opioid receptor agonist |
|---|
| Comment |
Opium alkaloid
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: UGT2B7 [HSA: 7364], UGT2B4 [HSA: 7363]; CYP3A4 [HSA: 1576], CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02A OPIOIDS
N02AA Natural opium alkaloids
N02AA08 Dihydrocodeine
D01481 Dihydrocodeine phosphate (JP18) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
22 Respiratory organ agents
224 Antitussives and expectorants
2242 Codeines
D01481 Dihydrocodeine phosphate (JP18)
8 Narcotics
81 Alkaloidal narcotics
811 Opium alkaloids
8115 Codeines
D01481 Dihydrocodeine phosphate (JP18)
Classification of Japanese OTC drugs [BR:br08313]
Agents for respiratory organs
26 Antitussives and expectorants
D01481 Dihydrocodeine phosphate (JP18)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Dihydrocodeine
D01481 Dihydrocodeine phosphate (JP18)
Second-class OTC drugs
Inorganic and organic chemicals
Dihydrocodeine
D01481 Dihydrocodeine phosphate (JP18)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00814 Dihydrocodeine
D01481 Dihydrocodeine phosphate
Analgesic
DG01984 Opioid analgesics
DG00814 Dihydrocodeine
D01481 Dihydrocodeine phosphate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00814 Dihydrocodeine
D01481 Dihydrocodeine phosphate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00814 Dihydrocodeine
D01481 Dihydrocodeine phosphate
DG02924 UGT substrate
DG03189 UGT2B4 substrate
DG00814 Dihydrocodeine
D01481 Dihydrocodeine phosphate
DG03190 UGT2B7 substrate
DG00814 Dihydrocodeine
D01481 Dihydrocodeine phosphate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D01481 Dihydrocodeine phosphate (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01481 Dihydrocodeine phosphate
D01481 1% dihydrocodeine phosphate powder
D01481 10% dihydrocodeine phosphate powder
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01481
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00814 Dihydrocodeine
Analgesic
DG01984 Opioid analgesics
DG00814 Dihydrocodeine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00814 Dihydrocodeine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00814 Dihydrocodeine
DG02924 UGT substrate
DG03189 UGT2B4 substrate
DG00814 Dihydrocodeine
DG03190 UGT2B7 substrate
DG00814 Dihydrocodeine
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 27
1 C1z C 7.1291 -11.7332
2 C8y C 7.1349 -10.4399
3 C1y C 8.2478 -12.3917
4 C1y C 6.0047 -12.3917
5 C1x C 8.0556 -10.8244
6 C8y C 6.0280 -9.7816
7 C8y C 8.2653 -9.8049
8 C1y C 9.3839 -11.7507
9 C1x C 8.2536 -13.6910
10 O2x O 4.7521 -11.0749
11 C1y C 6.0047 -13.6910
12 C1x C 10.4850 -10.8127
13 C8y C 6.0337 -8.4881
14 C1x C 9.3897 -10.4516
15 C8x C 8.2768 -8.5112
16 N1y N 10.5084 -12.4091
17 C1x C 7.1291 -14.3376
18 C8x C 7.1641 -7.8471
19 O2a O 4.9151 -7.8298
20 O1a O 4.8799 -14.3415
21 C1a C 3.7063 -8.5145
22 C1a C 11.9044 -12.4091
23 P1b P 16.2129 -11.4022
24 O1c O 17.5248 -11.4141
25 O1c O 14.9839 -11.4141
26 O1c O 16.2720 -12.8330
27 O1c O 16.2482 -9.7756
BOND 30
1 4 10 1 #Down
2 4 11 1
3 5 12 1
4 6 13 2
5 7 14 1
6 7 15 1
7 8 16 1 #Up
8 9 17 1
9 13 18 1
10 13 19 1
11 6 10 1
12 8 14 1
13 11 17 1
14 12 16 1
15 15 18 2
16 11 20 1 #Down
17 1 2 1
18 1 3 1
19 1 4 1
20 1 5 1 #Up
21 2 6 1
22 2 7 2
23 3 8 1
24 3 9 1
25 19 21 1
26 16 22 1
27 23 24 1
28 23 25 1
29 23 26 1
30 23 27 2
|
|---|
