| Entry |
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| Name |
Axitinib (JAN/USAN);
Inlyta (TN)
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| Product |
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| Formula |
C22H18N4OS
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| Exact mass |
386.1201
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| Mol weight |
386.4695
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| Structure |
     |
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| Activity |
Antineoplastic, inhibitor of VEGF/PDGF tyrosine kinases [DS: H00021]
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| Remark |
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| Target |
PDGFRB tyrosine kinase inhibitor [HSA: 5159] [KO: K05089]; VEGFR1 tyrosine kinase inhibitor [HSA: 2321] [KO: K05096]; VEGFR2 tyrosine kinase inhibitor [HSA: 3791] [KO: K05098]; VEGFR3 tyrosine kinase inhibitor [HSA: 2324] [KO: K05097]; c-KIT tyrosine kinase inhibitor [HSA: 3815] [KO: K05091] |
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| Pathway |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP3A5 [HSA: 1577]
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| Interaction |
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| Structure map |
| Antineoplastics - protein kinases inhibitors |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01X OTHER ANTINEOPLASTIC AGENTS
L01XE Protein kinase inhibitors
L01XE17 Axitinib
D03218 Axitinib (JAN/USAN)
Target-based classification of drugs [BR:br08310]
Cytokine receptors
Receptor tyrosine kinase
RTK class III (PDGF receptor family)
PDGFRB tyrosine kinase [HSA:5159] [KO:K05089]
Axitinib
D03218 Axitinib (JAN/USAN)
c-KIT tyrosine kinase [HSA:3815] [KO:K05091]
Axitinib
D03218 Axitinib (JAN/USAN)
RTK class V (VEGF receptor family)
VEGFR1 tyrosine kinase [HSA:2321] [KO:K05096]
Axitinib
D03218 Axitinib (JAN/USAN)
VEGFR2 tyrosine kinase [HSA:3791] [KO:K05098]
Axitinib
D03218 Axitinib (JAN/USAN)
VEGFR3 tyrosine kinase [HSA:2324] [KO:K05097]
Axitinib
D03218 Axitinib (JAN/USAN)
Antineoplastics [BR:br08308]
Molecularly targeted agents
Receptor tyrosine kinase inhibitors
Axitinib [ATC:L01XE17]
D03218 Axitinib (JAN/USAN)
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| Other DBs |
CAS: 319460-85-0 PubChem: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 28
1 C8y C 24.4171 -16.0231
2 C8x C 24.4171 -17.4283
3 C8x C 25.6340 -18.1309
4 C8y C 26.8510 -17.4283
5 C8y C 26.8510 -16.0231
6 C8x C 25.6340 -15.3205
7 C8y C 28.1874 -17.8625
8 N5x N 29.0134 -16.7257
9 N4x N 28.1874 -15.5889
10 S2a S 23.2002 -15.3205
11 C8y C 22.0003 -16.0134
12 C8y C 20.8085 -15.3254
13 C8x C 19.5916 -16.0281
14 C8x C 19.5917 -17.4333
15 C8x C 20.7834 -18.1212
16 C8x C 22.0003 -17.4186
17 C5a C 20.8084 -13.9155
18 N1b N 19.6105 -13.2238
19 O5a O 22.0443 -13.2016
20 C1a C 18.4201 -13.9112
21 C2b C 28.1874 -19.2625
22 C2b C 29.4111 -19.9692
23 C8y C 30.6235 -19.2695
24 N5x N 31.8023 -19.9503
25 C8x C 33.0148 -19.2505
26 C8x C 33.0150 -17.8505
27 C8x C 31.8362 -17.1697
28 C8x C 30.6237 -17.8695
BOND 31
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 2
9 8 9 1
10 5 9 1
11 1 10 1
12 10 11 1
13 11 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 15 16 2
18 11 16 1
19 12 17 1
20 17 18 1
21 17 19 2
22 18 20 1
23 7 21 1
24 21 22 2
25 22 23 1
26 23 24 2
27 24 25 1
28 25 26 2
29 26 27 1
30 27 28 2
31 23 28 1
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