KEGG   DRUG: Letermovir
Entry
D10801                      Drug                                   
Name
Letermovir (JAN/USAN/INN);
Prevymis (TN)
Product
PREVYMIS (Merck Sharp & Dohme LLC)
Formula
C29H28F4N4O4
Exact mass
572.2047
Mol weight
572.5506
Structure
Class
Antiviral
 DG01937  Anti-cytomegalovirus agent
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
Metabolizing enzyme inducer
 DG02886  CYP2C9 inducer
 DG02885  CYP2C19 inducer
Transporter substrate
 DG02856  SLCO1B1 substrate
 DG02932  SLCO1B3 substrate
Transporter inhibitor
 DG02862  ABCG2 inhibitor
 DG02865  SLCO1B1 inhibitor
 DG02907  SLCO1B3 inhibitor
Remark
Therapeutic category: 6250
ATC code: J05AX18
Product: D10801<JP/US>
Efficacy
Antiviral
  Disease
Cytomegalovirus infection [DS:H00368]
Comment
Treatment of human cytomegalovirus infection
Target
HCMV DNA terminase complex [KO:K26103 K26104 K26105]
Metabolism
Transporter: SLCO1B1 [HSA:10599], SLCO1B3 [HSA:28234]
Interaction
CYP induction: CYP2C9 [HSA:1559], CYP2C19 [HSA:1557]
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Transporter inhibition: ABCG2 [HSA:9429], SLCO1B1 [HSA:10599], SLCO1B3 [HSA:28234]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AX Other antivirals
     J05AX18 Letermovir
      D10801  Letermovir (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-cytomegalovirus (CMV) Agents
   Letermovir
    D10801  Letermovir (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D10801  Letermovir (JAN/USAN/INN)
Drug groups [BR:br08330]
 Antiviral
  DG01937  Anti-cytomegalovirus agent
   D10801  Letermovir
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   D10801  Letermovir
 Metabolizing enzyme inducer
  DG02886  CYP2C9 inducer
   D10801  Letermovir
  DG02885  CYP2C19 inducer
   D10801  Letermovir
 Transporter substrate
  DG02856  SLCO1B1 substrate
   D10801  Letermovir
  DG02932  SLCO1B3 substrate
   D10801  Letermovir
 Transporter inhibitor
  DG02862  ABCG2 inhibitor
   D10801  Letermovir
  DG02865  SLCO1B1 inhibitor
   D10801  Letermovir
  DG02907  SLCO1B3 inhibitor
   D10801  Letermovir
Drug classes [BR:br08332]
 Antiviral
  DG01937  Anti-cytomegalovirus agent
   D10801  Letermovir
Antimicrobials [BR:br08307]
 Antivirals
  Genome replication inhibitor
   Other inhibitor
    D10801  Letermovir (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10801
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10801
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10801
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10801
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10801
 Drug transporters
  D10801
Other DBs
PubChem: 316933537
LinkDB
KCF data

ATOM        41
            1   C8x C     4.3400  -15.4700
            2   C8x C     4.3400  -16.8700
            3   C8x C     5.5524  -17.5700
            4   C8y C     6.7649  -16.8700
            5   C8y C     6.7649  -15.4700
            6   C8y C     5.5524  -14.7700
            7   C1y C     7.9773  -17.5700
            8   N1y N     9.1897  -16.8700
            9   C2y C     9.1897  -15.4700
            10  N2x N     7.9773  -14.7700
            11  N1y N    10.3873  -14.7785
            12  C1x C    11.5756  -15.4645
            13  C1x C    12.7880  -14.7645
            14  N1y N    12.7880  -13.3645
            15  C1x C    11.5997  -12.6785
            16  C1x C    10.3873  -13.3785
            17  C8y C    14.0144  -12.6563
            18  C8x C    15.2219  -13.3533
            19  C8y C    16.4343  -12.6532
            20  C8x C    16.4342  -11.2532
            21  C8x C    15.2267  -10.5562
            22  C8x C    14.0143  -11.2563
            23  O2a O    17.6659  -13.3640
            24  C1a C    18.8561  -12.6764
            25  C8y C    10.3873  -17.5615
            26  C1b C     7.9773  -18.9700
            27  C6a C     6.7599  -19.6565
            28  C8y C    10.3873  -18.9697
            29  C8x C    11.5998  -19.6697
            30  C8x C    12.8122  -18.9697
            31  C8y C    12.8122  -17.5615
            32  C8x C    11.5997  -16.8615
            33  O2a O     9.1545  -19.6818
            34  C1a C     9.1545  -21.0818
            35  O6a O     5.5829  -18.9609
            36  O6a O     6.8152  -21.0693
            37  X   F     5.5524  -13.3702
            38  C1d C    14.0193  -16.8645
            39  X   F    15.2317  -16.1645
            40  X   F    13.3193  -15.6521
            41  X   F    14.7193  -18.0770
BOND        45
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   11  16 1
            19   14  17 1
            20   17  18 2
            21   18  19 1
            22   19  20 2
            23   20  21 1
            24   21  22 2
            25   17  22 1
            26   19  23 1
            27   23  24 1
            28    8  25 1
            29    7  26 1 #Up
            30   26  27 1
            31   25  28 2
            32   28  29 1
            33   29  30 2
            34   30  31 1
            35   31  32 2
            36   25  32 1
            37   28  33 1
            38   33  34 1
            39   27  35 1
            40   27  36 2
            41    6  37 1
            42   31  38 1
            43   38  39 1
            44   38  40 1
            45   38  41 1

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