KEGG   DISEASE: Endometrial cancerHelp
Entry
H00026                      Disease                                

Name
Endometrial cancer
Description
Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification.
Category
Cancer
Brite
Human diseases [BR:br08402]
 Cancers
  Cancers of the breast and female genital organs
   H00026  Endometrial cancer
Human diseases in ICD-10 classification [BR:br08403]
 2. Neoplasms (C00-D48)
  C51-C58  Malignant neoplasms of female genital organs
   C54  Malignant neoplasm of corpus uteri
    H00026  Endometrial Cancer
Cancer-accociated carbohydrates [br08441.html]
 H00026
BRITE hierarchy
Pathway
Endometrial cancer
Network
N00012  
Mutation-activated KRAS/NRAS to ERK signaling pathway
N00052  
Mutation-inactivated PTEN to PI3K signaling pathway
N00058  
Mutation-activated CTNNB1 to Wnt signaling pathway
N00115  
Mutation-inactivated TP53 to transcription
Gene
K-ras (mutational activation) [HSA:3845] [KO:K07827]
beta-Catenin (mutation) [HSA:1499] [KO:K02105]
ERBB2 (amplification) [HSA:2064] [KO:K05083]
PTEN (mutation, deletions, methylation) [HSA:5728] [KO:K01110]
p53 (mutation) [HSA:7157] [KO:K04451]
MLH1 (mutation, methylation) [HSA:4292] [KO:K08734]
Carcinogen
Estrogen therapy, postmenopausal
Tamoxifen [CPD:C07108]
Comment
ICD-O: 9380/3, Tumor type: Endometrioid adenocarcinoma
ICD-O: 8441/3, Tumor type: Serous adenocarcinoma
Other DBs
ICD-10: 
MeSH: 
Reference
PMID:17028294 (gene, tumor type)
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
PMID:15947972 (tumor type)
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
PMID:12583434 (gene)
  Authors
Salvesen HB, Akslen LA.
  Title
Molecular pathogenesis and prognostic factors in endometrial carcinoma.
  Journal
APMIS 110:673-89 (2002)
DOI:10.1034/j.1600-0463.2002.1101001.x
Reference
PMID:16508724 (gene)
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
PMID:17464097 (carcinogen)
  Authors
Ito K.
  Title
Hormone replacement therapy and cancers: the biological roles of estrogen and progestin in tumorigenesis are different between the endometrium and breast.
  Journal
Tohoku J Exp Med 212:1-12 (2007)
DOI:10.1620/tjem.212.1
Reference
PMID:17198307 (carcinogen)
  Authors
Yeh IT.
  Title
Postmenopausal hormone replacement therapy: endometrial and breast effects.
  Journal
Adv Anat Pathol 14:17-24 (2007)
DOI:10.1097/PAP.0b013e31802ef00f
Reference
PMID:10383884 (carcinogen)
  Authors
White IN.
  Title
The tamoxifen dilemma.
  Journal
Carcinogenesis 20:1153-60 (1999)
DOI:10.1093/carcin/20.7.1153
Reference
PMID:15203746 (marker)
  Authors
Marjoniemi VM.
  Title
Immunohistochemistry in gynaecological pathology: a review.
  Journal
Pathology 36:109-19 (2004)
DOI:10.1080/00313020410001671948
Reference
PMID:15188130 (marker)
  Authors
Prat J.
  Title
Prognostic parameters of endometrial carcinoma.
  Journal
Hum Pathol 35:649-62 (2004)
DOI:10.1016/j.humpath.2004.02.007
Reference
PMID:14739059 (marker)
  Authors
Gadducci A, Cosio S, Carpi A, Nicolini A, Genazzani AR.
  Title
Serum tumor markers in the management of ovarian, endometrial and cervical cancer.
  Journal
Biomed Pharmacother 58:24-38 (2004)
DOI:10.1016/j.biopha.2003.11.003
Reference
(drug)
  Authors
Papadakis MA and McPhee SJ |(ed)
  Title
Current Medical Diagnosis & Treatment 2015, Fifty-Fourth Edition
  Journal
McGraw Hill Education
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