KEGG   DISEASE: Parathyroid carcinomaHelp
Entry
H01558                      Disease                                

Name
Parathyroid carcinoma
Description
Parathyroid carcinoma (PC) is a highly aggressive endocrine tumor, with an annual incidence of less than 1 per million. Over 90% of patients present with excess parathyroid hormone (PTH), representing <1-5% of all patients with primary hyperparathyroidism. PC is associated with mutations in the HRPT2/CDC73 gene and with decreased parafibromin and calcium-sensing receptor (CASR) expression. Negative parafibromin staining together with a CDC73 gene mutation increases the likelihood of malignancy and also predicts the clinical outcome, namely local invasion and/or metastases and mortality. An increased mortality is predicted by either of these abnormality combined with down regulation of the calcium-sensing receptor (CaSR) expression.
Category
Cancer
Brite
Human diseases [BR:br08402]
 Cancers
  Cancers of endocrine organs
   H01558  Parathyroid carcinoma
Human diseases in ICD-10 classification [BR:br08403]
 2. Neoplasms (C00-D48)
  D00-D09  In situ neoplasms
   D09  Carcinoma in situ of other and unspecified sites
    H01558  Parathyroid carcinoma
BRITE hierarchy
Gene
CDC73/HRPT2 (mutation) [HSA:79577] [KO:K15175]
CASR [HSA:846] [KO:K04612]
Marker
CDC73/HRPT2 (Loss of nuclear and/or nucleolar expression) [HSA:79577] [KO:K15175]
PGP9.5 [HSA:7345] [KO:K05611]
Galectin-3 [HSA:3958] [KO:K06831]
Ki67 [HSA:4288] [KO:K17582]
Drug
Dacarbazine [DG:DG00680]
Fluorouracil [DG:DG00687]
Cyclophosphamide [DG:DG00675]
Other DBs
ICD-10: 
MeSH: 
Reference
PMID:26177319 (description, gene, marker)
  Authors
Duan K, Mete O
  Title
Parathyroid Carcinoma: Diagnosis and Clinical Implications.
  Journal
Turk Patoloji Derg 31 Suppl 1:80-97 (2015)
DOI:10.5146/tjpath.2015.01316
Reference
PMID:26312219 (drug)
  Authors
McClenaghan F, Qureshi YA
  Title
Parathyroid cancer.
  Journal
Gland Surg 4:329-38 (2015)
DOI:10.3978/j.issn.2227-684X.2015.05.09
Reference
PMID:24035866 (gene)
  Authors
Costa-Guda J, Arnold A
  Title
Genetic and epigenetic changes in sporadic endocrine tumors: parathyroid tumors.
  Journal
Mol Cell Endocrinol 386:46-54 (2014)
DOI:10.1016/j.mce.2013.09.005
Reference
PMID:20510594 (gene)
  Authors
Givi B, Shah JP
  Title
Parathyroid carcinoma.
  Journal
Clin Oncol (R Coll Radiol) 22:498-507 (2010)
DOI:10.1016/j.clon.2010.04.007
Reference
PMID:25002250 (marker)
  Authors
Truran PP, Johnson SJ, Bliss RD, Lennard TW, Aspinall SR
  Title
Parafibromin, galectin-3, PGP9.5, Ki67, and cyclin D1: using an immunohistochemical panel to aid in the diagnosis of parathyroid cancer.
  Journal
World J Surg 38:2845-54 (2014)
DOI:10.1007/s00268-014-2700-2
Reference
PMID:26675091 (marker)
  Authors
Karaarslan S, Yurum FN, Kumbaraci BS, Pala EE, Sivrikoz ON, Akyildiz M, Bugdayci MH
  Title
The Role of Parafibromin, Galectin-3, HBME-1, and Ki-67 in the Differential Diagnosis of Parathyroid Tumors.
  Journal
Oman Med J 30:421-7 (2015)
DOI:10.5001/omj.2015.84
Reference
PMID:27001435 (description, gene)
  Authors
Cetani F, Pardi E, Marcocci C
  Title
Update on parathyroid carcinoma.
  Journal
J Endocrinol Invest 39:595-606 (2016)
DOI:10.1007/s40618-016-0447-3
Reference
PMID:21240254 (description, gene)
  Authors
Witteveen JE, Hamdy NA, Dekkers OM, Kievit J, van Wezel T, Teh BT, Romijn JA, Morreau H
  Title
Downregulation of CASR expression and global loss of parafibromin staining are strong negative determinants of prognosis in parathyroid carcinoma.
  Journal
Mod Pathol 24:688-97 (2011)
DOI:10.1038/modpathol.2010.236
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