KEGG   ENZYME: 1.1.1.291Help
Entry
EC 1.1.1.291                Enzyme                                 

Name
2-hydroxymethylglutarate dehydrogenase;
HgD
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(S)-2-hydroxymethylglutarate:NAD+ oxidoreductase
Reaction(IUBMB)
(S)-2-hydroxymethylglutarate + NAD+ = 2-formylglutarate + NADH + H+ [RN:R07985]
Reaction(KEGG)
Substrate
(S)-2-hydroxymethylglutarate;
NAD+ [CPD:C00003]
Product
2-formylglutarate [CPD:C16159];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
NADP+ cannot replace NAD+. Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC 1.17.1.5 (nicotinate dehydrogenase), EC 1.3.7.1 (6-hydroxynicotinate reductase), EC 3.5.2.18 (enamidase), EC 5.4.99.4 (2-methyleneglutarate mutase), EC 5.3.3.6 (methylitaconate Delta-isomerase), EC 4.2.1.85 (dimethylmaleate hydratase) and EC 4.1.3.32 (2,3-dimethylmalate lyase).
History
EC 1.1.1.291 created 2006
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K19647  2-hydroxymethylglutarate dehydrogenase
Genes
CPAT: CLPA_c02850(hgd)
CPAE: CPAST_c02850(hgd)
DOR: Desor_0451
TEP: TepRe1_0398
TAE: TepiRe1_0442(Hgd)
NTH: Nther_2161
IPO: Ilyop_0116
Taxonomy
Reference
1  [PMID:16894175]
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 12341-6.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.291
IUBMB Enzyme Nomenclature: 1.1.1.291
ExPASy - ENZYME nomenclature database: 1.1.1.291
BRENDA, the Enzyme Database: 1.1.1.291
CAS: 1073478-76-8
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