KEGG   ENZYME: 1.1.1.39Help
Entry
EC 1.1.1.39                 Enzyme                                 

Name
malate dehydrogenase (decarboxylating);
'malic' enzyme;
pyruvic-malic carboxylase;
NAD-specific malic enzyme;
NAD-malic enzyme
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(S)-malate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(S)-malate + NAD+ = pyruvate + CO2 + NADH [RN:R00214]
Reaction(KEGG)
Substrate
(S)-malate [CPD:C00149];
NAD+ [CPD:C00003]
Product
pyruvate [CPD:C00022];
CO2 [CPD:C00011];
NADH [CPD:C00004]
Comment
Does not decarboxylate added oxaloacetate.
History
EC 1.1.1.39 created 1961
Pathway
Pyruvate metabolism
Carbon fixation in photosynthetic organisms
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K00028  
malate dehydrogenase (decarboxylating)
Genes
ATH: 
AT2G13560(NAD-ME1) AT4G00570(NAD-ME2)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
POPTR_0002s13630g(POPTRDRAFT_816506) POPTR_0002s15740g(POPTRDRAFT_552135) POPTR_0014s04320g POPTR_0014s07570g(POPTRDRAFT_731028)
VVI: 
SLY: 
SOT: 
102581802(NAD-ME) 102598070(NAD-ME)
OSA: 
DOSA: 
Os07t0496200-01(Os07g0496200) Os10t0503500-01(Os10g0503500)
OBR: 
BDI: 
SBI: 
SORBI_01g017790(SORBIDRAFT_01g017790) SORBI_02g033920(SORBIDRAFT_02g033920)
ZMA: 
SITA: 
ATR: 
s00002p00145340(AMTR_s00002p00145340) s00009p00262080(AMTR_s00009p00262080)
SMO: 
PPP: 
CRE: 
OLU: 
OTA: 
MIS: 
MICPUN_55180(NAD-ME)
CSL: 
CVR: 
SPY: 
SPG: 
SPS: 
SPH: 
SPI: 
SPJ: 
SPK: 
SPF: 
LCA: 
EFA: 
 » show all
Taxonomy
Reference
1  [PMID:13416294]
  Authors
SAZ HJ, HUBBARD JA.
  Title
The oxidative decarboxylation of malate by Ascaris lumbricoides.
  Journal
J. Biol. Chem. 225 (1957) 921-33.
  Organism
Ascaris lumbricoides
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-46-0
LinkDB All DBs

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