KEGG   ENZYME: 1.1.1.39Help
Entry
EC 1.1.1.39                 Enzyme                                 
Name
malate dehydrogenase (decarboxylating);
'malic' enzyme;
pyruvic-malic carboxylase;
NAD-specific malic enzyme;
NAD-malic enzyme
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(S)-malate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(S)-malate + NAD+ = pyruvate + CO2 + NADH [RN:R00214]
Reaction(KEGG)
Substrate
(S)-malate [CPD:C00149];
NAD+ [CPD:C00003]
Product
pyruvate [CPD:C00022];
CO2 [CPD:C00011];
NADH [CPD:C00004]
Comment
Does not decarboxylate added oxaloacetate.
Pathway
Pyruvate metabolism
Carbon fixation in photosynthetic organisms
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K00028  
malate dehydrogenase (decarboxylating)
Genes
ATH: 
AT2G13560(NAD-ME1) AT4G00570(NAD-ME2)
ALY: 
GMX: 
MTR: 
RCU: 
POP: 
VVI: 
OSA: 
DOSA: 
Os07t0496200-01(Os07g0496200) Os10t0503500-01(Os10g0503500)
BDI: 
SBI: 
SORBI_01g017790(SORBIDRAFT_01g017790) SORBI_02g033920(SORBIDRAFT_02g033920)
ZMA: 
100501486
SMO: 
SELMODRAFT_110809
PPP: 
PHYPADRAFT_198570
CRE: 
CHLREDRAFT_196833(MME1)
OLU: 
OSTLU_26919
OTA: 
Ot12g02700
SPY: 
SPy_1110
SPG: 
SpyM3_0771
SPS: 
SPs0971
SPH: 
MGAS10270_Spy0949
SPI: 
MGAS10750_Spy0984
SPJ: 
MGAS2096_Spy0908
SPK: 
MGAS9429_Spy0952
SPF: 
SpyM50955
LCA: 
LSEI_2866
EFA: 
EF1206
 » show all
Taxonomy
Reference
1  [PMID:13416294]
  Authors
SAZ HJ, HUBBARD JA.
  Title
The oxidative decarboxylation of malate by Ascaris lumbricoides.
  Journal
J. Biol. Chem. 225 (1957) 921-33.
  Organism
Ascaris lumbricoides
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-46-0
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