| Entry |
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| Name |
glutathione amide-dependent peroxidase
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| Class |
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
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| Sysname |
glutathione amide:hydrogen-peroxide oxidoreductase
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| Reaction(IUBMB) |
2 glutathione amide + H2O2 = glutathione amide disulfide + 2 H2O [RN: R09563]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
This enzyme, which has been characterized from the proteobacterium Marichromatium gracile, is a chimeric protein, containing a peroxiredoxin-like N-terminus and a glutaredoxin-like C terminus. The enzyme has peroxidase activity towards hydrogen peroxide and several small alkyl hydroperoxides, and is thought to represent an early adaptation for fighting oxidative stress [1]. The glutathione amide disulfide produced by this enzyme can be restored to glutathione amide by EC 1.8.1.16 (glutathione amide reductase).
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| History |
EC 1.11.1.17 created 2010
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| Reference |
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| Authors |
Vergauwen B, Pauwels F, Jacquemotte F, Meyer TE, Cusanovich MA, Bartsch RG, Van Beeumen JJ |
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| Title |
Characterization of clutathione amide reductase from Chromatium gracile. Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling. |
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| Journal |
J. Biol. Chem. 276 (2001) 20890-7. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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