| Entry |
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| Name |
bromide peroxidase;
bromoperoxidase;
haloperoxidase (ambiguous);
eosinophil peroxidase
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| Class |
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
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| Sysname |
bromide:hydrogen-peroxide oxidoreductase
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| Reaction(IUBMB) |
RH + HBr + H2O2 = RBr + 2 H2O [RN: R09505]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Bromoperoxidases of red and brown marine algae (Rhodophyta and Phaeophyta) contain vanadate. They catalyse the bromination of a range of organic molecules such as sesquiterpenes, forming stable C-Br bonds. Bromoperoxidases also oxidize iodides.
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| History |
EC 1.11.1.18 created 2010
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| Orthology |
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| Reference |
1 |
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| Authors |
De Boer, E., Tromp, M.G.M., Plat, H., Krenn, G.E. and Wever, R |
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| Title |
Vanadium(v) as an essential element for haloperoxidase activity in marine brown-algae - purification and characterization of a vanadium(V)-containing bromoperoxidase from Laminaria saccharina. |
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| Journal |
Biochim. Biophys. Acta 872 (1986) 104-115. |
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| Reference |
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| Authors |
Tromp MG, Olafsson G, Krenn BE, Wever R |
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| Title |
Some structural aspects of vanadium bromoperoxidase from Ascophyllum nodosum. |
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| Journal |
Biochim. Biophys. Acta. 1040 (1990) 192-8. |
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| Reference |
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| Authors |
Isupov MN, Dalby AR, Brindley AA, Izumi Y, Tanabe T, Murshudov GN, Littlechild JA |
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| Title |
Crystal structure of dodecameric vanadium-dependent bromoperoxidase from the red algae Corallina officinalis. |
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| Journal |
J. Mol. Biol. 299 (2000) 1035-49. |
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| Sequence |
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| Reference |
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| Authors |
Carter-Franklin JN, Butler A |
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| Title |
Vanadium bromoperoxidase-catalyzed biosynthesis of halogenated marine natural products. |
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| Journal |
J. Am. Chem. Soc. 126 (2004) 15060-6. |
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| Reference |
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| Authors |
Ohshiro T, Littlechild J, Garcia-Rodriguez E, Isupov MN, Iida Y, Kobayashi T, Izumi Y |
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| Title |
Modification of halogen specificity of a vanadium-dependent bromoperoxidase. |
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| Journal |
Protein. Sci. 13 (2004) 1566-71. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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