| Entry |
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| Name |
3-methyl-L-tyrosine peroxygenase;
SfmD;
SacD;
3-methyltyrosine peroxidase;
3-methyl-L-tyrosine peroxidase
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| Class |
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxygenases
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| Sysname |
3-methyl-L-tyrosine:hydrogen-peroxide oxidoreductase (3-hydroxy-5-methyl-L-tyrosine-forming)
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| Reaction(IUBMB) |
3-methyl-L-tyrosine + H2O2 = 3-hydroxy-5-methyl-L-tyrosine + H2O [RN: R10721]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
3-hydroxy-5-methyl-L-tyrosine [CPD: C20801];
H2O [CPD: C00001]
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| Comment |
The heme-containing peroxygenase from the bacterium Streptomyces lavendulae is involved in biosynthesis of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family.
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| History |
EC 1.11.2.5 created 2014
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| Orthology |
| 3-methyl-L-tyrosine peroxygenase |
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| Reference |
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| Authors |
Tang MC, Fu CY, Tang GL |
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| Title |
Characterization of SfmD as a Heme peroxidase that catalyzes the regioselective hydroxylation of 3-methyltyrosine to 3-hydroxy-5-methyltyrosine in saframycin A biosynthesis. |
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| Journal |
J. Biol. Chem. 287 (2012) 5112-21. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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