| Entry |
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| Name |
4-hydroxymandelate synthase;
4-hydroxyphenylpyruvate dioxygenase II
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| Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
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| Sysname |
(S)-4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)
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| Reaction(IUBMB) |
4-hydroxyphenylpyruvate + O2 = (S)-4-hydroxymandelate + CO2 [RN: R06632]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Requires Fe2+. Involved in the biosynthesis of the vancomycin group of glycopeptide antibiotics.
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| History |
EC 1.13.11.46 created 2001
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| Pathway |
| Monobactam biosynthesis | | Biosynthesis of vancomycin group antibiotics | | Biosynthesis of antibiotics |
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| Orthology |
| 4-hydroxymandelate synthase |
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| Genes |
MSD: | | AGE: | | SCO: | | SVL: | | SBH: | | SRC: | | SALU: | | SALL: | | SLV: | | SVT: | | STRE: | | STRC: | | SAMB: | | SRW: | | SPAV: | | SLC: | | STSI: | | SNR: | | SPLU: | | KSK: | | KFL: | | SRO: | | NOA: | | FRA: | | AOI: | | AJA: | | ALU: | | AMI: | | KAL: | | ACTI: | | ACAD: | | STP: | | SAQ: | | MAU: | | MIL: | | VMA: | | CAI: | | HAU: | |
» show all
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| Reference |
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| Authors |
Hubbard BK, Thomas MG, Walsh CT |
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| Title |
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics. |
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| Journal |
Chem. Biol. 7 (2000) 931-42. |
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| Sequence |
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| Reference |
2 |
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| Authors |
Choroba, O.W., Williams, D.H. and Spencer, J.B. |
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| Title |
Biosynthesis of the vancomycin group of antibiotics: involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine. |
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| Journal |
J. Am. Chem. Soc. 122 (2000) 5389-5390. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 280566-04-3 |
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| LinkDB |
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