| Entry |
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| Name |
tryptophan 2'-dioxygenase;
indole-3-alkane alpha-hydroxylase;
tryptophan side-chain alpha,beta-oxidase;
tryptophan side chain oxidase II;
tryptophan side-chain oxidase;
TSO;
indolyl-3-alkan alpha-hydroxylase;
tryptophan side chain oxidase type I;
TSO I ;
TSO II;
tryptophan side chain oxidase
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| Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
Miscellaneous
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| Sysname |
L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)
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| Reaction(IUBMB) |
L-tryptophan + O2 = (indol-3-yl)glycolaldehyde + CO2 + NH3 [RN: R00681]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A hemoprotein. Acts on a number of indole-3-alkane derivatives, oxidizing the 3-side-chain in the 2'-position. Best substrates were L-tryptophan and 5-hydroxy-L-tryptophan.
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| History |
EC 1.13.99.3 created 1984
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| Pathway |
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| Reference |
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| Authors |
Roberts J, Rosenfeld HJ. |
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| Title |
Isolation, crystallization, and properties of indolyl-3-alkane alpha-hydroxylase. A novel tryptophan-metabolizing enzyme. |
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| Journal |
J. Biol. Chem. 252 (1977) 2640-7. |
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| Reference |
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| Authors |
Takai K, Ushiro H, Noda Y, Narumiya S, Tokuyama T. |
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| Title |
Crystalline hemoprotein from Pseudomonas that catalyzes oxidation of side chain of tryptophan and other indole derivatives. |
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| Journal |
J. Biol. Chem. 252 (1977) 2648-56. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 64295-81-4 |
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| LinkDB |
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