KEGG   ENZYME: 1.14.11.1Help
Entry
EC 1.14.11.1                Enzyme                                 

Name
gamma-butyrobetaine dioxygenase;
alpha-butyrobetaine hydroxylase;
gamma-butyrobetaine hydroxylase;
butyrobetaine hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2 [RN:R02397]
Reaction(KEGG)
Substrate
4-trimethylammoniobutanoate [CPD:C01181];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
3-hydroxy-4-trimethylammoniobutanoate [CPD:C00487];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and ascorbate.
History
EC 1.14.11.1 created 1972
Pathway
Lysine degradation
Orthology
K00471  
gamma-butyrobetaine dioxygenase
Genes
HSA: 
8424(BBOX1)
PTR: 
466474(BBOX1)
PPS: 
100987653(BBOX1)
GGO: 
101131986(BBOX1)
PON: 
100173794(BBOX1)
NLE: 
100592137(BBOX1)
MCC: 
100425366(BBOX1) 699465(BBOX1)
MCF: 
101864912(BBOX1)
CSAB: 
103238580(BBOX1)
RRO: 
104671120(BBOX1)
CJC: 
100394422(BBOX1)
SBQ: 
101035393(BBOX1)
MMU: 
170442(Bbox1)
RNO: 
64564(Bbox1)
CGE: 
100759730(Bbox1)
NGI: 
103741027(Bbox1)
HGL: 
101702765(Bbox1)
CCAN: 
109680391(Bbox1)
OCU: 
100356171(BBOX1)
TUP: 
102477622(BBOX1)
CFA: 
476894(BBOX1)
AML: 
100467920(BBOX1)
UMR: 
103659370(BBOX1)
FCA: 
101082182(BBOX1)
PTG: 
102966727(BBOX1)
AJU: 
106970275(BBOX1)
BTA: 
507159(BBOX1)
BOM: 
102278682(BBOX1)
BIU: 
109569931(BBOX1)
PHD: 
102315518(BBOX1)
CHX: 
102179499(BBOX1)
OAS: 
101115823(BBOX1)
SSC: 
100519353(BBOX1)
CFR: 
102512431(BBOX1)
BACU: 
103016705(BBOX1)
LVE: 
103082783(BBOX1)
ECB: 
100072253(BBOX1)
MYB: 
102248153(BBOX1)
MYD: 
102755785(BBOX1)
HAI: 
109373324(BBOX1)
RSS: 
109456738(BBOX1)
PALE: 
102894724(BBOX1)
LAV: 
100668456(BBOX1)
MDO: 
100030745(BBOX1)
SHR: 
100933762(BBOX1)
OAA: 
100080259(BBOX1)
GGA: 
426932(BBOX1)
MGP: 
100548089(BBOX1)
CJO: 
107314364(BBOX1)
APLA: 
101793349(BBOX1)
TGU: 
100222550(BBOX1)
GFR: 
102042420(BBOX1)
FAB: 
101821064(BBOX1)
PHI: 
102106518(BBOX1) 106628479
CCW: 
104692930(BBOX1)
FPG: 
101921157(BBOX1)
FCH: 
102053623(BBOX1)
CLV: 
102092334(BBOX1)
AAM: 
106498227(BBOX1)
ASN: 
102382469(BBOX1)
AMJ: 
102567742(BBOX1)
PSS: 
102444784(BBOX1)
CMY: 
102936607(BBOX1)
CPIC: 
101940563(BBOX1)
ACS: 
100561261(bbox1)
PBI: 
103066330(BBOX1)
GJA: 
107122568(BBOX1)
XLA: 
108715211(bbox1.S)
XTR: 
100145728(bbox1)
DRE: 
572649(bbox1)
IPU: 
108259295(bbox1)
TRU: 
101071219(bbox1)
TNG: 
GSTEN00018177G001
LCO: 
104920628(bbox1)
MZE: 
101466552(bbox1)
OLA: 
101162990(bbox1)
XMA: 
102227274(bbox1)
CSEM: 
103378801(bbox1)
SASA: 
106561934 106587091
LCM: 
102355837(BBOX1)
CMK: 
103174979(bbox1)
BFO: 
BRAFLDRAFT_212201 BRAFLDRAFT_219801 BRAFLDRAFT_78941 BRAFLDRAFT_87944
CIN: 
100180618
SPU: 
577198
SKO: 
100369969 100370368 100372811 100375284 100375436
DME: 
Dmel_CG10814(CG10814) Dmel_CG4335 Dmel_CG5321
DPO: 
Dpse_GA10576 Dpse_GA18803 Dpse_GA22704
DAN: 
Dana_GF11192 Dana_GF19297 Dana_GF22125
DER: 
Dere_GG12825 Dere_GG17850 Dere_GG22499
DPE: 
Dper_GL11099 Dper_GL14222 Dper_GL20147
DSE: 
Dsec_GM12042 Dsec_GM19110 Dsec_GM20285
DSI: 
Dsimw501_GD16541(Dsim_GD16541) Dsimw501_GD17176(Dsim_GD17176) Dsimw501_GD25765(Dsim_GD25765)
DWI: 
Dwil_GK14708 Dwil_GK16355 Dwil_GK17984
DYA: 
Dyak_GE13368 Dyak_GE16657 Dyak_GE17150
DGR: 
Dgri_GH11991 Dgri_GH12513 Dgri_GH20273
DMO: 
Dmoj_GI14867 Dmoj_GI15613 Dmoj_GI19441
DVI: 
Dvir_GJ15218 Dvir_GJ19528 Dvir_GJ21194
MDE: 
101891259 101893754 101894750
AGA: 
AgaP_AGAP008246 AgaP_AGAP012477
AAG: 
AaeL_AAEL001707
CQU: 
CpipJ_CPIJ017090 CpipJ_CPIJ017091
BMOR: 
101743493
PXY: 
105390519
API: 
100568468 100575304
PHU: 
Phum_PHUM477100
DPX: 
DAPPUDRAFT_207173
ISC: 
IscW_ISCW012479 IscW_ISCW012481 IscW_ISCW024731
CEL: 
CELE_D2089.5(gbh-1) CELE_M05D6.7(gbh-2)
CBR: 
CBG03032(Cbr-gbh-1)
LGI: 
LOTGIDRAFT_233281
NVE: 
NEMVE_v1g167335 NEMVE_v1g243354
ADF: 
107327306 107327319 107327320 107327321 107331124
HMG: 
101238208
TAD: 
TRIADDRAFT_38529
AQU: 
100633264 100633736 105312168
PIC: 
PICST_33061(GBO1)
SRE: 
PTSG_07142
SMIN: 
v1.2.003014.t1(symbB.v1.2.003014.t1) v1.2.010310.t1(symbB.v1.2.010310.t1) v1.2.041171.t1(symbB.v1.2.041171.t1)
AAF: 
AURANDRAFT_62370
GTT: 
GUITHDRAFT_164324
PMY: 
Pmen_0503
PFL: 
PFL_5756
PPRC: 
PFLCHA0_c57090
PPRO: 
PPC_5702
PFO: 
Pfl01_5234
PFS: 
PFLU_4654
PFE: 
PSF113_5458
PFN: 
HZ99_05555
PFW: 
PF1751_v1c51000
PFF: 
PFLUOLIPICF710490
PFX: 
A7318_25085
PMAN: 
OU5_3943
PCG: 
AXG94_13180
PAZO: 
AYR47_04540 AYR47_20405
PBA: 
PSEBR_a5239
PBC: 
CD58_27505
PPUU: 
PputUW4_05037
PSV: 
PVLB_12435
PSK: 
U771_29385
PCH: 
EY04_31840
PCZ: 
PCL1606_05050
PCP: 
JM49_02635
PSEM: 
TO66_29120
PSOS: 
POS17_5690
PKR: 
AYO71_28035
PFK: 
PFAS1_13510
PANR: 
A7J50_5402
ALT: 
ambt_12790
ASP: 
AOR13_2361
ASQ: 
AVL57_10495
AAW: 
AVL56_09635
CSA: 
Csal_0540 Csal_2770 Csal_3171
HEL: 
HELO_1569 HELO_2757
HAK: 
KO116_01623
HAM: 
HALO1690
HHU: 
AR456_09255 AR456_09265
HALO: 
BWR19_14955
CMAI: 
BFX80_03010 BFX80_06240 BFX80_09875 BFX80_16080
MARS: 
A8C75_09130 A8C75_16655 A8C75_21935
TSN: 
W908_07695
BPS: 
BPSS1110
BPM: 
BURPS1710b_A0070 BURPS1710b_A1680(pvcB)
BPL: 
BURPS1106A_A1481
BPD: 
BURPS668_A1569
BPSE: 
BDL_4396
BPSM: 
BBQ_5061
BPSU: 
BBN_4535
BPSD: 
BBX_3561
BPZ: 
BP1026B_II1173
BPQ: 
BPC006_II1485
BPK: 
BBK_6001
BPSH: 
DR55_4217
BPSA: 
BBU_4952
BPSO: 
X996_4311
BUT: 
X994_6047
BOK: 
DM82_5272 DM82_5369
BOC: 
BG90_5239 BG90_5337
BVI: 
Bcep1808_3389
BVE: 
AK36_3372
BUR: 
Bcep18194_B0616
BCN: 
Bcen_3320
BCH: 
Bcen2424_5047
BCM: 
Bcenmc03_5237
BCJ: 
BCAM2290
BCEW: 
DM40_4990
BCEO: 
I35_6181
BAM: 
Bamb_4455
BAC: 
BamMC406_4975
BCT: 
GEM_3400 GEM_4721
BCED: 
DM42_5701
BCEP: 
APZ15_27665
BDL: 
AK34_3509
BPYR: 
ABD05_24135
BCON: 
NL30_01110
BUB: 
BW23_3453
BDF: 
WI26_24135
BLAT: 
WK25_27430
BTEI: 
WS51_08470
BSEM: 
WJ12_31340
BMEC: 
WJ16_29790
BSTG: 
WT74_30165
BGL: 
bglu_2g17560
BGP: 
BGL_2c23480
BGU: 
KS03_4173
BGD: 
bgla_2g05780
BGO: 
BM43_4216
BUK: 
MYA_3007
BPLA: 
bpln_2g23760
ALP: 
LPB137_05315
MYM: 
A176_001848
SUR: 
STAUR_2090
CCRO: 
CMC5_014140
SAMY: 
DB32_002785
MRM: 
A7982_09697
HOH: 
Hoch_4369
MLO: 
mll1440
MLN: 
A9174_18900
MCI: 
Mesci_3237
MOP: 
Mesop_3629
MAM: 
Mesau_03502
MAMO: 
A6B35_22570
MESW: 
A9K65_017530
HOE: 
IMCC20628_01348 IMCC20628_01439
AVI: 
Avi_3411
AGC: 
BSY240_950
RLB: 
RLEG3_03455
RBM: 
TEF_17550
SIL: 
SPO3380
SIT: 
TM1040_0052 TM1040_0333 TM1040_2006
RMB: 
K529_000315
PGA: 
PGA1_c27220
PGL: 
PGA2_c25240
PGD: 
Gal_00639 Gal_00705
PHP: 
PhaeoP97_02668
OAT: 
OAN307_c19610
OAR: 
OA238_c21470
LMD: 
METH_08250
HAT: 
RC74_16275
LAP: 
ACP90_09620 ACP90_19975
LAGG: 
B0E33_03695 B0E33_21555
DON: 
BSK21_10315
TPRO: 
Ga0080559_TMP3867
ANH: 
A6F65_00135
APC: 
HIMB59_00001420
MMAE: 
MMARE11_06410(tauD_1)
MLI: 
MULP_00691(tauD_1)
SGS: 
AVL59_28950
KSK: 
KSE_56020
LMOI: 
VV02_08475
FRI: 
FraEuI1c_0586
PSEA: 
WY02_15675
PSEE: 
FRP1_27130
PSEH: 
XF36_26945
PSEQ: 
AD006_06310
PECQ: 
AD017_14125
PHH: 
AFB00_11845
KAL: 
KALB_3391
TER: 
Tery_0693 Tery_2451
MPRO: 
BJP34_15525 BJP34_27290 BJP34_27535 BJP34_27540 BJP34_28885 BJP34_30050 BJP34_34645
HSI: 
BOX17_04605 BOX17_07480 BOX17_10405
 » show all
Taxonomy
Reference
1  [PMID:4396068]
  Authors
Lindstedt G, Lindstedt S.
  Title
Cofactor requirements of gamma-butyrobetaine hydroxylase from rat liver.
  Journal
J. Biol. Chem. 245 (1970) 4178-86.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9045-31-2
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