| Entry |
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| Name |
hyoscyamine (6S)-dioxygenase;
hyoscyamine 6beta-hydroxylase;
hyoscyamine 6beta-dioxygenase;
hyoscyamine 6-hydroxylase
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
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| Sysname |
L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase [(6S)-hydroxylating]
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| Reaction(IUBMB) |
L-hyoscyamine + 2-oxoglutarate + O2 = (6S)-hydroxyhyoscyamine + succinate + CO2 [RN: R03812]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Requires Fe2+ and ascorbate.
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| History |
EC 1.14.11.11 created 1989
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| Pathway |
| Tropane, piperidine and pyridine alkaloid biosynthesis | | Metabolic pathways | | Biosynthesis of secondary metabolites |
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| Orthology |
| hyoscyamine (6S)-dioxygenase |
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| Reference |
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| Authors |
Hashimoto T, Yamada Y. |
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| Title |
Hyoscyamine 6beta-Hydroxylase, a 2-Oxoglutarate-Dependent Dioxygenase, in Alkaloid-Producing Root Cultures. |
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| Journal |
Plant. Physiol. 81 (1986) 619-625. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 103865-33-4 |
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| LinkDB |
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