| Entry |
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| Name |
6beta-hydroxyhyoscyamine epoxidase;
hydroxyhyoscyamine dioxygenase;
(6S)-6-hydroxyhyoscyamine,2-oxoglutarate oxidoreductase (epoxide-forming)
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
 |
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| Sysname |
(6S)-6beta-hydroxyhyoscyamine,2-oxoglutarate:oxygen oxidoreductase (epoxide-forming)
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| Reaction(IUBMB) |
(6S)-6beta-hydroxyhyoscyamine + 2-oxoglutarate + O2 = scopolamine + succinate + CO2 + H2O [RN: R03737]
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| Reaction(KEGG) |
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| Substrate |
(6S)-6beta-hydroxyhyoscyamine;
2-oxoglutarate [CPD: C00026];
O2 [CPD: C00007]
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| Product |
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| Comment |
Requires Fe2+ and ascorbate.
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| History |
EC 1.14.11.14 created 1992
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| Pathway |
| Tropane, piperidine and pyridine alkaloid biosynthesis | | Metabolic pathways | | Biosynthesis of secondary metabolites |
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| Reference |
1 |
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| Authors |
Hashimoto, T., Kohno, J. and Yamada, Y. |
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| Title |
6beta-Hydroxyhyoscyamine epoxidase from cultured roots of Hyoscyamus niger. |
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| Journal |
Phytochemistry 28 (1989) 1077-1082. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 121479-53-6 |
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| LinkDB |
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