| Entry |
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| Name |
peptide-aspartate beta-dioxygenase;
aspartate beta-hydroxylase;
aspartylpeptide beta-dioxygenase
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
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| Sysname |
peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
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| Reaction(IUBMB) |
peptide-L-aspartate + 2-oxoglutarate + O2 = peptide-3-hydroxy-L-aspartate + succinate + CO2 [RN: R04073]
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| Reaction(KEGG) |
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| Substrate |
peptide-L-aspartate;
2-oxoglutarate [CPD: C00026];
O2 [CPD: C00007]
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| Product |
peptide-3-hydroxy-L-aspartate;
succinate [CPD: C00042];
CO2 [CPD: C00011]
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| Comment |
Requires Fe2+. Some vitamin K-dependent coagulation factors, as well as synthetic peptides based on the structure of the first epidermal growth factor domain of human coagulation factor IX or X, can act as acceptors.
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| History |
EC 1.14.11.16 created 1992
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| Orthology |
| aspartate beta-hydroxylase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | NLE: | | MCC: | | MCF: | | CSAB: | | RRO: | | CJC: | | SBQ: | | MMU: | | RNO: | | CGE: | | NGI: | | HGL: | | CCAN: | | OCU: | | TUP: | | CFA: | | AML: | | UMR: | | FCA: | | PTG: | | AJU: | | BTA: | | BOM: | | BIU: | | PHD: | | CHX: | | OAS: | | SSC: | | CFR: | | BACU: | | LVE: | | ECB: | | MYB: | | MYD: | | HAI: | | RSS: | | PALE: | | LAV: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | CJO: | | APLA: | | GFR: | | FAB: | | PHI: | | CCW: | | FPG: | | FCH: | | CLV: | | AAM: | | ASN: | | AMJ: | | PSS: | | CMY: | | CPIC: | | ACS: | | PBI: | | GJA: | | XLA: | | XTR: | | DRE: | | IPU: | | TRU: | | TNG: | | MZE: | | OLA: | | XMA: | | CSEM: | | SASA: | | LCM: | | CMK: | | BFO: | | CIN: | | SPU: | | SKO: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | MDE: | | AAG: | | CQU: | | BIM: | | BTER: | | AEC: | | HST: | | CFO: | | TCA: | | BMOR: | | PXY: | | PHU: | | DPX: | | ISC: | | CEL: | | CBR: | | NAI: | | BMY: | | LOA: | | TSP: | | LGI: | | CRG: | | OBI: | | NVE: | | ADF: | | TAD: | | AQU: | | OTA: | | MIS: | | SRE: | | ACAN: | | TET: | | SMIN: | | FCY: | | AAF: | | NGD: | | PIF: | | PSOJ: | | SPAR: | | EHX: | | GTT: | | NGR: | | SPE: | | SRR: | | SRL: | | SRY: | | SPLY: | | SRS: | | SRA: | | SMW: | | SMAR: | | SMAC: | | SLQ: | | SERF: | | SERS: | | DJI: | | DJA: | | AMAA: | | AMAL: | | AMAE: | | AMAO: | | AMAI: | | LPN: | | LPF: | | LPP: | | LPC: | | BMA: | | BML: | | BMN: | | BMAI: | | BMAF: | | BMAZ: | | BMAB: | | BPS: | | BPM: | | BPL: | | BPD: | | BPSE: | | BPSM: | | BPSU: | | BPSD: | | BPZ: | | BPQ: | | BPK: | | BPSH: | | BPSA: | | BPSO: | | BUT: | | BTE: | | BTQ: | | BTJ: | | BTZ: | | BTD: | | BTV: | | BTHE: | | BTHM: | | BTHA: | | BTHL: | | BOK: | | BOC: | | BVI: | | BVE: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BCEN: | | BCEW: | | BCEO: | | BAM: | | BAC: | | BMU: | | BMK: | | BMUL: | | BCT: | | BCED: | | BCEP: | | BDL: | | BPYR: | | BCON: | | BUB: | | BDF: | | BLAT: | | BTEI: | | BSEM: | | BPSL: | | BMEC: | | BGL: | | BGP: | | BGU: | | BGD: | | BGO: | | BUK: | | BUL: | | BPLA: | | BUD: | | PKT: | | CCX: | | MLO: | | MLN: | | NOA: | | SYNR: | | SYND: | | MPRO: | |
» show all
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| Reference |
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| Authors |
Gronke RS, Welsch DJ, VanDusen WJ, Garsky VM, Sardana MK, Stern AM, Friedman PA. |
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| Title |
Partial purification and characterization of bovine liver aspartyl beta-hydroxylase. |
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| Journal |
J. Biol. Chem. 265 (1990) 8558-65. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 122544-66-5 |
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| LinkDB |
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