| Entry |
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| Name |
pyrimidine-deoxynucleoside 2'-dioxygenase;
deoxyuridine 2'-dioxygenase;
deoxyuridine 2'-hydroxylase;
pyrimidine deoxyribonucleoside 2'-hydroxylase;
thymidine 2'-dioxygenase;
thymidine 2'-hydroxylase;
thymidine 2-oxoglutarate dioxygenase;
thymidine dioxygenase
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
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| Sysname |
2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (2'-hydroxylating)
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| Reaction(IUBMB) |
2'-deoxyuridine + 2-oxoglutarate + O2 = uridine + succinate + CO2 [RN: R01879]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Requires Fe(II) and ascorbate. Also acts on thymidine. cf. EC 1.14.11.10, pyrimidine-deoxynucleoside 1'-dioxygenase.
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| History |
EC 1.14.11.3 created 1972, modified 1976, modified 1989, modified 2002
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| Reference |
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| Authors |
Bankel L, Lindstedt G, Lindstedt S. |
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| Title |
Thymidine 2'-hydroxylation in Neurospora crassa. |
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| Journal |
J. Biol. Chem. 247 (1972) 6128-34. |
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| Reference |
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| Authors |
Stubbe J. |
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| Title |
Identification of two alpha-ketoglutarate-dependent dioxygenases in extracts of Rhodotorula glutinis catalyzing deoxyuridine hydroxylation. |
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| Journal |
J. Biol. Chem. 260 (1985) 9972-5. |
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| Reference |
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| Authors |
Warn-Cramer BJ, Macrander LA, Abbott MT. |
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| Title |
Markedly different ascorbate dependencies of the sequential alpha-ketoglutarate dioxygenase reactions catalyzed by an essentially homogeneous thymine 7-hydroxylase from Rhodotorula glutinis. |
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| Journal |
J. Biol. Chem. 258 (1983) 10551-7. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9076-89-5 |
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| LinkDB |
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