| Entry |
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| Name |
thebaine 6-O-demethylase;
T6ODM
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
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| Sysname |
thebaine,2-oxoglutarate:oxygen oxidoreductase (6-O-demethylating)
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| Reaction(IUBMB) |
thebaine + 2-oxoglutarate + O2 = neopinone + formaldehyde + succinate + CO2 [RN: R05126]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Requires Fe2+. Catalyses a step in morphine biosynthesis. The product neopinione spontaneously rearranges to the more stable codeinone. The enzyme also catalyses the 6-O-demethylation of oripavine to morphinone, with lower efficiency.
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| History |
EC 1.14.11.31 created 2010
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| Pathway |
| Isoquinoline alkaloid biosynthesis | | Metabolic pathways | | Biosynthesis of secondary metabolites |
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| Orthology |
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| Reference |
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| Authors |
Hagel JM, Facchini PJ |
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| Title |
Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy. |
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| Journal |
Nat. Chem. Biol. 6 (2010) 273-5. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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