Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

fumitremorgin B,2-oxoglutarate:oxygen oxidoreductase (verruculogen-forming)

fumitremorgin B + 2-oxoglutarate + 2 O2 + reduced acceptor = verruculogen + succinate + CO2 + H2O + acceptor [RN:R10445]

R10445

fumitremorgin B [CPD:C20630];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
reduced acceptor [CPD:C00030]

Requires Fe2+ and ascorbate. Found in the fungus Aspergillus fumigatus. Both atoms of a dioxygen molecule are incorporated into verruculogen [1,2]. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgin A.

EC 1.14.11.38 created 2013

1  [PMID:19763315]

Steffan N, Grundmann A, Afiyatullov S, Ruan H, Li SM

FtmOx1, a non-heme Fe(II) and alpha-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus.

Org. Biomol. Chem. 7 (2009) 4082-7.

[afm:AFUA_8G00230]

2  [PMID:21404415]

Kato N, Suzuki H, Takagi H, Uramoto M, Takahashi S, Osada H

Gene disruption and biochemical characterization of verruculogen synthase of Aspergillus fumigatus.

Chembiochem. 12 (2011) 711-4.