| Entry |
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| Name |
enduracididine beta-hydroxylase;
MppO;
L-enduracididine,2-oxoglutarate:O2 oxidoreductase (3-hydroxylating)
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
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| Sysname |
L-enduracididine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
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| Reaction(IUBMB) |
L-enduracididine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-enduracididine + succinate + CO2 [RN: R10413]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Fe2+-dependent enzyme. The enzyme is involved in biosynthesis of the nonproteinogenic amino acid beta-hydroxyenduracididine, a component of the mannopeptimycins (cyclic glycopeptide antibiotic), produced by Streptomyces hygroscopicus NRRL 30439.
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| History |
EC 1.14.11.40 created 2013
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| Orthology |
| enduracididine beta-hydroxylase |
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| Reference |
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| Authors |
Haltli B, Tan Y, Magarvey NA, Wagenaar M, Yin X, Greenstein M, Hucul JA, Zabriskie TM |
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| Title |
Investigating beta-hydroxyenduracididine formation in the biosynthesis of the mannopeptimycins. |
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| Journal |
Chem. Biol. 12 (2005) 1163-8. |
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| Sequence |
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| Reference |
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| Authors |
Magarvey NA, Haltli B, He M, Greenstein M, Hucul JA |
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| Title |
Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogens. |
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| Journal |
Antimicrob. Agents. Chemother. 50 (2006) 2167-77. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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