| Entry |
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| Name |
tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase;
TYW5;
tRNA yW-synthesizing enzyme 5
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
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| Sysname |
tRNAPhe 7-(3-amino-3-carboxypropyl)wyosine37,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating)
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| Reaction(IUBMB) |
7-(3-amino-3-carboxypropyl)wyosine37 in tRNAPhe + 2-oxoglutarate + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine37 in tRNAPhe + succinate + CO2 [RN: R10522]
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| Reaction(KEGG) |
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| Substrate |
7-(3-amino-3-carboxypropyl)wyosine37 in tRNAPhe;
2-oxoglutarate [CPD: C00026];
O2 [CPD: C00007]
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| Product |
7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine37 in tRNAPhe;
succinate [CPD: C00042];
CO2 [CPD: C00011]
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| Comment |
Requires Fe2+. The enzyme is not active with wybutosine.
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| History |
EC 1.14.11.42 created 2013
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| Orthology |
| tRNA wybutosine-synthesizing protein 5 |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | NLE: | | MCC: | | MCF: | | CSAB: | | RRO: | | CJC: | | SBQ: | | MMU: | | RNO: | | CGE: | | NGI: | | HGL: | | CCAN: | | OCU: | | TUP: | | CFA: | | AML: | | UMR: | | FCA: | | PTG: | | AJU: | | BTA: | | BOM: | | BIU: | | PHD: | | CHX: | | OAS: | | SSC: | | CFR: | | BACU: | | LVE: | | ECB: | | MYB: | | MYD: | | HAI: | | RSS: | | PALE: | | LAV: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | CJO: | | APLA: | | TGU: | | GFR: | | FAB: | | PHI: | | CCW: | | FPG: | | FCH: | | CLV: | | AAM: | | ASN: | | AMJ: | | PSS: | | CMY: | | CPIC: | | ACS: | | PBI: | | GJA: | | XLA: | | XTR: | | DRE: | | IPU: | | TRU: | | TNG: | | LCO: | | MZE: | | OLA: | | XMA: | | CSEM: | | SASA: | | LCM: | | CMK: | | BFO: | | CIN: | | SPU: | | SKO: | | PHU: | | DPX: | | ISC: | | TSP: | | HRO: | | LGI: | | CRG: | | OBI: | | NVE: | | ADF: | | HMG: | | TAD: | | AQU: | | CRE: | | BPG: | | MIS: | | MPP: | | MLR: | | TOT: | | BEQ: | | GTT: | | NGR: | |
» show all
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| Reference |
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| Authors |
Noma A, Ishitani R, Kato M, Nagao A, Nureki O, Suzuki T |
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| Title |
Expanding role of the jumonji C domain as an RNA hydroxylase. |
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| Journal |
J. Biol. Chem. 285 (2010) 34503-7. |
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| Sequence |
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| Reference |
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| Authors |
Kato M, Araiso Y, Noma A, Nagao A, Suzuki T, Ishitani R, Nureki O |
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| Title |
Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification. |
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| Journal |
Nucleic. Acids. Res. 39 (2011) 1576-85. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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