| Entry |
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| Name |
(S)-dichlorprop dioxygenase (2-oxoglutarate);
SdpA;
alpha-ketoglutarate-dependent (S)-dichlorprop dioxygenase;
(S)-phenoxypropionate/alpha-ketoglutarate-dioxygenase;
2-oxoglutarate-dependent (S)-dichlorprop dioxygenase;
(S)-mecoprop dioxygenase;
2-oxoglutarate-dependent (S)-mecoprop dioxygenase
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
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| Sysname |
(S)-2-(4-chloro-2-methylphenoxy)propanoate,2-oxoglutarate:oxygen oxidoreductase (pyruvate-forming)
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| Reaction(IUBMB) |
(1) (S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 = 4-chloro-2-methylphenol + pyruvate + succinate + CO2 [RN: R10527];
(2) (S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + pyruvate + succinate + CO2 [RN: R10487]
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| Reaction(KEGG) |
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| Substrate |
(S)-2-(4-chloro-2-methylphenoxy)propanoate [CPD: C20686];
2-oxoglutarate [CPD: C00026];
O2 [CPD: C00007];
(S)-(2,4-dichlorophenoxy)propanoate [CPD: C20687]
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| Product |
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| Comment |
Fe2+-dependent enzyme. The enzymes from the Gram-negative bacteria Delftia acidovorans MC1 and Sphingomonas herbicidovorans MH are involved in the degradation of the (S)-enantiomer of the phenoxyalkanoic acid herbicides mecoprop and dichlorprop [1,2].
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| History |
EC 1.14.11.43 created 2013
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| Orthology |
| (S)-dichlorprop dioxygenase (2-oxoglutarate) |
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| Genes |
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| Reference |
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| Authors |
Westendorf A, Benndorf D, Muller RH, Babel W |
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| Title |
The two enantiospecific dichlorprop/alpha-ketoglutarate-dioxygenases from Delftia acidovorans MC1--protein and sequence data of RdpA and SdpA. |
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| Journal |
Microbiol. Res. 157 (2002) 317-22. |
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| Sequence |
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| Reference |
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| Authors |
Muller TA, Fleischmann T, van der Meer JR, Kohler HP |
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| Title |
Purification and characterization of two enantioselective alpha-ketoglutarate-dependent dioxygenases, RdpA and SdpA, from Sphingomonas herbicidovorans MH. |
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| Journal |
Appl. Environ. Microbiol. 72 (2006) 4853-61. |
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| Reference |
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| Authors |
Muller TA, Zavodszky MI, Feig M, Kuhn LA, Hausinger RP |
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| Title |
Structural basis for the enantiospecificities of R- and S-specific phenoxypropionate/alpha-ketoglutarate dioxygenases. |
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| Journal |
Protein. Sci. 15 (2006) 1356-68. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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