| Entry |
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| Name |
2-aminoethylphosphonate dioxygenase;
phnY (gene name)
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
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| Sysname |
(2-aminoethyl)phosphonate,2-oxoglutarate:oxygen oxidoreductase (1-hydroxylating)
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| Reaction(IUBMB) |
(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 = (2-amino-1-hydroxyethyl)phosphonate + succinate + CO2 [RN: R10724]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
(2-amino-1-hydroxyethyl)phosphonate [CPD: C05678];
succinate [CPD: C00042];
CO2 [CPD: C00011]
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| Comment |
Requires Fe2+ and ascorbate. The enzyme, characterized from an uncultured marine bacterium, is involved in a (2-aminoethyl)phosphonate degradation pathway.
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| History |
EC 1.14.11.46 created 2014
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| Pathway |
| Phosphonate and phosphinate metabolism |
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| Orthology |
| 2-aminoethylphosphonate dioxygenase |
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| Genes |
FVR: | | FOX: | | MAW: | | MAJ: | | BFU: | | PSCO: | | AOR: | | ANG: | | AFV: | | NFI: | | PCS: | | PFJ: | | BCOM: | | MPR: | | MRR: | | ACAN: | | PTI: | | FCY: | | EHX: | | SRL: | | SRY: | | PPZ: | | LHA: | | NOC: | | NHL: | | NWA: | | BOK: | | BOC: | | BPLA: | | BCAI: | | CPRA: | | ARA: | | RGI: | | PSWU: | | FRA: | | AYM: | | ABAI: | | SYND: | | PMF: | | PMG: | | NCN: | | SNG: | | PIR: | | PLS: | | PCM: | |
» show all
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| Reference |
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| Authors |
McSorley FR, Wyatt PB, Martinez A, DeLong EF, Hove-Jensen B, Zechel DL |
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| Title |
PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon-phosphorus bond. |
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| Journal |
J. Am. Chem. Soc. 134 (2012) 8364-7. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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